Institution
Roussel Uclaf
About: Roussel Uclaf is a based out in . It is known for research contribution in the topics: Alkyl & Alkoxy group. The organization has 1888 authors who have published 2338 publications receiving 36508 citations.
Topics: Alkyl, Alkoxy group, Aryl, Carbon, Carboxylic acid
Papers published on a yearly basis
Papers
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29 Apr 1974TL;DR: In this article, the authors disclosed pharmaceutically-active aminoglycosides comprising 4-O-[2',6'-diamino-2', 6'-didesoxy-α-D-glucopyranosyl] 6-O]-3"-methylamino-3",4",6"-tridesoxy -α-d-xylohexopyranoyl] 2-desoxy streptamine of the formula: ##SPC1## And the addition salts thereof with mineral acids or organic acids.
Abstract: There are disclosed pharmaceutically-active aminoglycosides comprising 4-O-[2',6'-diamino-2',6'-didesoxy-α-D-glucopyranosyl] 6-O-[3"-methylamino-3",4",6"-tridesoxy-α-D-xylohexopyranosyl] 2-desoxy streptamine of the formula: ##SPC1## And the addition salts thereof with mineral acids or organic acids. Also disclosed are methods for preparation of the novel products as well as certain novel intermediate products. There are also disclosed pharmaceutical compositions in which the novel products are the active agents as well as methods for use of compositions as antibiotic agents.
10 citations
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TL;DR: The dopamine (DA) agonist activity of new simplified ergoline derivatives (RU 27849, RU 28251, and RU 28306) was studied in comparison with bromocriptine and induced an intense contralateral circling behavior in 6‐OHDA‐lesioned rats.
Abstract: The dopamine (DA) agonist activity of new simplified ergoline derivatives (RU 27849, RU 28251, and RU 28306) was studied in comparison with bromocriptine. In contrast to bromocriptine, the three compounds were weak displacers of 3H-dihydroergocriptine or 3H-spiroperidol binding from bovine anterior pituitary or rat striatal membrane sites and weak inhibitors of prolactin secretion in anterior pituitary cells in culture. Similarly to bromocriptine, they did not induce changes in either the basal or the DA-induced stimulation of the adenylate cyclase activities. In vivo, the three derivatives, at a low dose, increased plasma prolactin levels, decreased striatal DA turnover, and increased striatal acetylcholine content, as did bromocriptine. Furthermore, in 6-OHDA-lesioned rats, these molecules, like bromocriptine, induced an intense contralateral circling behavior. From their effectiveness in these different tests, the potencies of these new ergoline derivatives can be ranked in the following order : N-propyl > N-methyl > N-H.
10 citations
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TL;DR: Uterine myometrial contractile activity under RU 486 exposure was not sufficient to induce labour and delivery in Cynomolgus monkeys and the progesterone antagonist concentration in breast milk was very low, indicating little passage to suckling newborn infants.
Abstract: The hormonal mechanisms of parturition in primates remain controversial. Even so, the well-known decrease of plasma progesterone concentration near term is considered by many as the 'labour inducer'. The progesterone antagonist RU 486, which blocks progesterone activity at the cellular receptor level, appears to be a useful hormonal tool by which to study this tissue. Here, we tested its capacity to induce labour and delivery. A total of 23 Cynomolgus monkeys (Macaca fascicularis), within 9-17 days of expected term, were assigned to four different protocols to study various doses, routes and regimens of RU 486 administration. Observations included uterine contractile patterns, pharmacokinetics of RU 486 in plasma and passage of RU 486 into breast milk. None of the protocols tested successfully induced labour resulting in vaginal delivery within 24 h. Instead, the data demonstrate that blockade of progesterone activity by the progesterone antagonist was not sufficient by itself to achieve parturition in these primates. Uterine myometrial contractile activity under RU 486 exposure was not sufficient to induce labour and delivery. Moreover, the progesterone antagonist concentration in breast milk was very low, indicating little passage to suckling newborn infants.
10 citations
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TL;DR: In this article, the group aminoborane joue un double rǒle, en protegeant l'azote tertiaire lors de l'oxydation chromique de la fonction alcool, and en induisant la protonation stereospecifique en position γ de 1'intermediaire dienolique.
10 citations
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TL;DR: The results obtained in the laboratory indicate that aldosterone has a direct stimulatory action on ouabain-dependent and on oUABain-independent Na efflux, and the mineralocorticoid enhances passive K permeability, as well as the Na pump dependent K influx.
10 citations
Authors
Showing all 1888 results
Name | H-index | Papers | Citations |
---|---|---|---|
Fernand Labrie | 110 | 885 | 48308 |
Lionel H. Opie | 84 | 519 | 25964 |
Alain Bélanger | 70 | 244 | 16469 |
Michel J. Tremblay | 53 | 273 | 10485 |
Pierre Monsan | 51 | 216 | 8049 |
Samir Z. Zard | 50 | 575 | 10739 |
Alejandro Aruffo | 47 | 123 | 14084 |
Samuel S.C. Yen | 47 | 96 | 6865 |
Dominique Maraninchi | 47 | 188 | 8108 |
Serge Erlinger | 46 | 152 | 8200 |
Romain Lefebvre | 40 | 221 | 5269 |
William B. Motherwell | 39 | 305 | 6357 |
Jean-Pierre Raynaud | 38 | 104 | 5075 |
André Lemay | 38 | 114 | 4264 |
Patrick J. Creaven | 32 | 102 | 3435 |