Roussel Uclaf

About: Roussel Uclaf is a based out in . It is known for research contribution in the topics: Alkyl & Alkoxy group. The organization has 1888 authors who have published 2338 publications receiving 36508 citations.

Trans-4-aminobenz(c,d)indol-5-ol derivatives, their salts, their preparation, their use as medicaments and compositions containing them

Abstract: 1. Racemic or resolved derivatives of trans 4-amino benz(c,d) indol-5-ol, as well as their addition salts with mineral or organic acids, answering to the general formula (I) : see diagramm : EP0091328,P17,F1 in which R1 represents : a hydrogen atom ; a linear or branched alkyl radical containing from 1 to 8 carbon atoms, possibly substituted by one or more halogen atoms, by one or more hydroxy radicals or by a phenyl or phenoxy radical possibly substituted on the phenyl nucleus by one or more halogen atoms or by one or more hydroxy, methyl or methoxy radicals, a cycloalkyl radical containing from 3 to 7 carbon atoms, a cycloalkylalkyl radical containing from 4 to 7 carbon atoms, or an alkenyl or alkynyl radical containing from 3 to 6 carbon atoms, the dotted line at 2-2a represents a possible second carbon-carbon bond and R represents a hydrogen atom.

DELTA 1,3,5(10)-Estratrienes

Abstract: Novel 11 beta -substituted- DELTA 1,3,5(10)-estratrienes of the formula I wherein R1 is selected from the group consisting of optionally substituted unsaturated alkyl of 2 to 8 carbon atoms, optionally substituted aryl of 6 to 12 carbon atoms, optionally substituted aralkyl of 7 to 13 carbon atoms and heterocycle with at least one sulfur or oxygen heteroatom, R2 is alkyl of 1 to 4 carbon atoms, Z is selected from the group consisting of hydrogen, alkyl of 1 to 12 carbon atoms and aralkyl of 7 to 9 carbon atoms, R3 is selected from the group consisting of hydrogen, hydroxy, acyl of an organic carboxylic acid of 1 to 18 carbon atoms and acyloxy of an organic carboxylic acid of 1 to 18 carbon atoms and R4 is selected from the group consisting of hydrogen, hydroxy, alkyl and alkoxy of 1 to 8 carbon atoms, acyloxy of an organic carboxylic acid of 1 to 8 carbon atoms and alkenyl and alkynyl of 2 to 8 carbon atoms, with the proviso that R1 is not allyl when Z is hydrogen, R2 is methyl, R3 is hydroxy and R4 is hydrogen having estrogenic activity and their preparation.

Lactic acid acylates

Abstract: All possible isomeric forms, racemic mixtures and enantiomeric and diastereoisomeric forms of a compound selected from the group consisting of a compound of the formula ##STR1## wherein R is alkenyl of 10 carbon atoms, n is an integer from 1 to 3 and their non-toxic salts useful for treating comedones.

Method of controlling male fertility

Abstract: A method of controlling male fertility in warm-blooded male animals comprising administering to male warm-blooded animals an amount of a compound selected from the group consisting of a compound of the formula ##STR1## wherein R1 and R2 are taken together with the nitrogen to form a saturated 5 to 6 ring heterocycle, optionally containing a second nitrogen or oxygen in the ring, R3 is α- or β-methyl, n is an integer from 2 to 10, R4 and R5 together are ═0 or R4 is selected from the group consisting of hydrogen, --OH and acyloxy of an organic carboxylic acid of up to 12 carbon atoms and R5 is selected from the group consisting of hydrogen, --OH, acyloxy of an organic carboxylic acid of up to 12 carbon atoms and alkyl, alkenyl and alkynyl of up to 8 carbon atoms, R6 and R7 together are ═0 or are individually selected from the group consisting of hydrogen, --OH and acyloxy of an organic carboxylic acid of up to 12 carbon atoms or R5 and R6 form a double bond and R4 and R7 are hydrogen and their non-toxic, pharmaceutically, acceptable acid addition salts in an amount sufficient to control male fertility.