Roussel Uclaf

About: Roussel Uclaf is a based out in . It is known for research contribution in the topics: Alkyl & Alkoxy group. The organization has 1888 authors who have published 2338 publications receiving 36508 citations.

Imidazole derivatives, process for their preparation, novel intermediate products, their applications as pharmaceuticals and pharmaceutical compositions holding same

Abstract: PRECIS DE LA DIVULGATION: ABSTRACT OF THE DISCLOSURE: L'invention a pour objet les produits de formule (I): The invention relates to the products of formula (I): (I) dans laquelle: A represente reste d'un radical car-boxyclique ou heterocyclique sature ou insature, R (I) wherein: A is residue of a radical as boxyclique-or heterocyclic saturated or unsaturated, R represente alkyle, alkenyle ou alkynyle; represents alkyl, alkenyl or alkynyl; R1, R2, R3 et R4, representent hydrogene; R1, R2, R3 and R4 represent hydrogen; halogene; halogen; hydroxyle; hydroxyl; cyano; cyano; nitro; nitro; sulfo; sulfo; formyle; formyl; benzoyle; benzoyl; acyle; acyl; acyloxy; acyloxy; carboxy libre, salifie ou esterifie; carboxy free, salified or esterified; mercapto; mercapto; alkyle; alkyl; alkenyle; alkenyl; alkynyle; alkynyl; alkoxy; alkoxy; alkylthio; alkylthio; aryle; aryl; arylalkyle; arylalkyl; arylalkenyle; arylalkenyl; -(CH2)m-SO2-X-R14; - (CH2) m-SO2-X-R14; ou or dans lesquels: ou bien R6 et R7 ou R8 et R9, identiques ou differents, representent hydrogene, alkyle, alkenyle, aryle, arylalkyle, et -(CH2)m-SO2-X-R14 avec m represente 0 a 4, soit X-R4 represente NH2, soit X represente -NH-, -NH-CO-NH-ou -NH-CO- ou simple liaison et R14 represente alkyle, alkenyle ou aryle, ou bien R6 et R7 ou R8 et R9 forment avec azote auquel ils sont lies un radical carboxyclique ou heterocyclique, ou bien R8 et R9, identiques ou differents, representent acyle, alkyl ou arylsulfonyle; in which: either R6 and R7 or R8 and R9, identical or different, represent hydrogen, alkyl, alkenyl, aryl, arylalkyl, and - (CH2) m-SO2-X-R14 where m is 0 to 4, or X R4 represents NH2, or X represents -NH-, -NH-CO-NH-or -NH-CO- or single bond and R14 represents alkyl, alkenyl or aryl, or R6 and R7 or R8 and R9 together with nitrogen to which they are attached form a carbocyclic or heterocyclic radical, or R8 and R9, identical or different, represent acyl, alkyl or arylsulfonyl; R5 represente alkylene; R5 is alkylene; Y represente -Y1-B-Y2 dans lequel: Y1 represente aryle carboxyclique ou heterocyclique eventuellement substitues par R1, R2, R3 et R4, B represente: soit simple liaison entre Y1 et Y2, soit -CO-, -NH-CO-, -CO-NH- ou -O-(CH2)n- avec n representent 0 a 3, Y2 represente Y1, si B Y is -Y1-Y2-B wherein: Y 1 represents carbocyclic aryl or heterocyclic group optionally substituted by R1, R2, R3 and R4, B represents: either single bond between Y1 and Y2, or -CO-, -NH-CO-, -CO-NH- or -O- (CH2) n- with n represent 0 to 3, Y2 is Y1, if B represente une simple liaison, hydrogene, cyano, carboxy libre, salifie ou esterifie, etant entendu que: lorsque A represents a single bond, hydrogen, cyano, carboxy free, salified or esterified, it being understood that: when A represente phenyle eventuellement substitue par halogene, alkyle, alkoxy, acyle, carboxy libre ou phenyle substitue represents phenyl optionally substituted by halogen, alkyl, alkoxy, acyl, free carboxy or substituted phenyl par 5 atomes de fluor, R5 represente -CH2-, et Y represente -Y1-B-Y2 dans lequel Y1 represente phenyle non substitue et Y2 represente phenyle substitue en ortho par carboxy libre eventuellement salifie, tetrazolyle, trifluoro-methyl-sulfonamide et eventuellement halogene, alkyle, nitro ou methoxy, alors B represente -CO-NH- ou -O-(CH2)n- avec n representant 2 ou 3, lesdits produits de formule (I) etant sous toutes les formes isomeres possibles racemiques, enantiomeres et diastereoisomeres, ainsi que les sels d'addition avec les acides mineraux et organiques ou avec les bases minerales et organiques desdits produits de formule (I). by 5 fluorine atoms, R5 is -CH2-, and Y is -Y1-B-Y2 wherein Y1 represents unsubstituted phenyl and Y 2 is phenyl substituted ortho free carboxy optionally salified tetrazolyl, trifluoro-methyl-sulfonamide and optionally halogen, alkyl, nitro or methoxy, then B represents -CO-NH- or -O- (CH2) n- where n is 2 or 3, said products of formula (I) being in all the possible racemic, enantiomeric and diastereoisomers, and the addition salts with mineral and organic acids or with mineral and organic bases of said products of formula (I). L'invention concerne egalement un procede de fabrication desdits produits, leur usage pour la preparation de medicaments, les compositions pharmaceutiques contenant lesdits produits et des intermediaires pour la preparation desdits produits. The invention also relates to a method for manufacturing said products, their use for the preparation of medicaments, pharmaceutical compositions containing said products and intermediates for the preparation of said products.

Process for preparing pentacyclic alkaloids

Abstract: PROCESS FOR PREPARING PENTACYCLIC ALKLOIDS OF GENERAL FORMULA: 12-(CH3-OOC-),12-HO,13A-(CH3-CH2-)-1,2,5,6,12,13-3H- INDOLO(3,2,1-DE)PYRIDO(3,2,1-IJ)(1,5)NAPHTHYRIDINE