Roussel Uclaf

About: Roussel Uclaf is a based out in . It is known for research contribution in the topics: Alkyl & Alkoxy group. The organization has 1888 authors who have published 2338 publications receiving 36508 citations.

Five day treatment of pharyngotonsillitis with cefpodoxime proxetil

Abstract: A ten day course of oral penicillin is still recommended for pharyngotonsillitis with the aim of eradicating Streptococcus pyogenes and preventing rheumatic fever. However there is some evidence that penicillin V therapy is less satisfactory than in former years. Several explanations have been suggested, including inadequate pharmacokinetic properties, poor patient compliance, penicillin tolerance, re-infection and carrier state, and indirect pathogenicity. In this context we evaluated the efficacy of third generation cephalosporins. We have shown that a short course of five days treatment with cefpodoxime is as effective as the ten days of conventional treatment with penicillin in terms of both clinical and bacteriological efficacy. Moreover the possibility of reducing the duration of therapy and the twice daily administration of these new cephalosporins results in better patient compliance with treatment.

Erythromycin derivatives, their process of preparation and their use as medicaments

Abstract: Erythromycin derivs. of formula (I) and their acid addn. salts, are new. R = -(CH2)nAr; n = 3 - 5; Ar = heterocyclic gp. (opt. substd. one or more times) (37 gps shown in specification); or R = a gp. (i); Z = H or an acid residue. Ar can also be a gp. (a)-(e) (opt. substd.); R can also be a gp. (ii) or (iii); (opt. substd.). Also claimed are amines RNH2 (III) and their acid addn. salts.

Affinity of the interaction between Fcgamma receptor type III (FcγRIII) and monomeric human IgG subclasses. Role of FcγRIII glycosylation

Abstract: Binding of the Fc region of IgG antibodies to low affinity Fc gamma receptors (Fc gammaR) triggers important effector functions in the immune system. The type IIIb Fc gammaR (Fc gammaRIIIb or CD16) is a heavily glycosylated protein anchored to the membrane of neutrophils by a glycosylphosphatidylinositol link. This receptor contributes to cell activation by IgG immune complexes. To better understand the nature of the ligand-receptor association, we have studied the affinity and kinetics of the interaction between human IgG subclasses and two soluble forms of Fc gammaRIIIb (sFc gammaRIIIb or sCD16) corresponding to the 188 N-terminal amino acids of the extracellular region of the receptor, a glycosylated one made in eucaryotic cells (euc.sCD16) and a non-glycosylated one (proc.sCD16) made in Escherichia coli. Experiments using a BIAcore instrument, to measure protein binding in real time, showed that monomeric human IgG1 and IgG3, but not IgG2, IgG4, IgA and divalent antigen-binding fragments (F(ab')2) of IgG1, bound to immobilized euc.sCD16 with an affinity constant (K(A)) of 1.3 +/- 0.6 x 10(6) M(-1) and 2.6 +/- 0.4 x 10(5) M(-1), respectively. The affinity constant of proc.sCD16 for human IgG1 was in the same range (1.1 +/- 0.2 x 10(6) M(-1)), whereas that for human IgG3 was twofold higher (4.2 +/- 0.4 x 10(5) M(-1)). The specificity of the non-glycosylated receptor for human IgG subclasses bound to Sepharose was IgG1 > IgG3 >> IgG4 >>> IgG2. Thus, the extracellular polypeptide of Fc gammaRIIIb dictates the interaction of the receptor with IgG subclasses although glycosylation plays an inhibitory role in the interaction with human IgG3.

Neuere Ergebnisse bei der Totalsynthese von Steroiden

Abstract: Es wird die Darstellung verschiedener Steroide in optisch reiner Form beschrieben. Als Ausgangs-substanz fur alle Synthesen wird zunachst aus 6-Methoxy-α-tetralon eine tricyclische Verbindung hergestellt, die wohl den funfgliedrigen D-Ring, nicht aber die angulare 19-Methyl-Gruppe besitzt. Charakteristisch fur die neue Synthese ist die fruhzeitige Racemat-Spaltung einer Carbonsaure und die Vorbereitung des A-Ringes durch Kondensation mit 1.3-Dichlor-buten-(2). Das Kondensations-produkt besitzt die anti-trans-Konfiguration der naturlichen Steroide, es erlaubt die Herstellung sowohl von nor-Derivaten als auch—durch Einfuhrung der 19β-Methyl-Gruppe— die Synthese naturlicher Steroide (Ostradiol, Adrenosteron, Cortison).