Institution
Roussel Uclaf
About: Roussel Uclaf is a based out in . It is known for research contribution in the topics: Alkyl & Alkoxy group. The organization has 1888 authors who have published 2338 publications receiving 36508 citations.
Topics: Alkyl, Alkoxy group, Aryl, Carbon, Carboxylic acid
Papers published on a yearly basis
Papers
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TL;DR: In this article, decision levels of sex steroid hormones in cattle husbandry were established, taking into account the effect of the treatment, for the cases of the urine of male and female veal calves treated with estradiol and/or testosterone-containing implants, and the plasma of bulls treated by an injection of an estradio-testosterone cocktail.
30 citations
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TL;DR: Data show that 5 alpha 3 alpha P enhanced the activity of the GABAA receptor complex at the pituitary level and suggest that its inhibitory effect on prolactin release might be mediated by the barbiturate site or by a closely related site.
30 citations
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TL;DR: Ofloxacin showed excellent in-vitro activity against Enterobacteriaceae while most strains of Pseudomonas aeruginosa were inhibited by less than 2 mg/l, and was significantly more potent than norfl oxacin against Acinetobacter spp.
Abstract: Ofloxacin (DL8280, RU43280) is a newly introduced oxazine quinolone derivative with broad and potent antibacterial activity. Ofloxacin showed excellent in-vitro activity against Enterobacteriaceae while most strains of Pseudomonas aeruginosa were inhibited by less than 2 mg/l. The compound was significantly more potent than norfloxacin against Acinetobacter spp. and Staphylococcus spp. Ofloxacin and norfloxacin behaved similarly with respect to inoculum size, effect of urine and serum, bactericidal properties and frequency of spontaneous resistant mutants. Ofloxacin displayed an in-vivo antibacterial activity up to five times greater than that of pefloxacin and norfloxacin, probably due to the conjunction of favourable pharmacokinetics, excellent bacterial susceptibility and good stability towards metabolic degradation.
30 citations
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28 Dec 1989TL;DR: The compounds of formula (I) as discussed by the authors are compounds in which a hydrogen atom, a halogen atom or a cyano, NO2 or CF3 radical is fused to an aryl radical.
Abstract: The invention relates to the compounds of formula (I): … … in which:… - X and X', which may be identical or different, represent a hydrogen atom, a halogen atom or a cyano, NO2 or CF3 radical;… - R represents a hydrogen atom or an alkyl radical; and… - Ar represents an aryl radical, an aromatic heterocyclic radical or a heterocyclic radical fused to an aryl radical. … The compounds of formula (I) possess advantageous pharmacological properties which justify their use in therapy.
30 citations
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TL;DR: To test the validity of the combined superposition, a Comparative Molecular Field Analysis was carried out within SYBYL, using recently published in vivo and in vitro binding data for insecticides to show a significant statistical correlation with the published biological data.
Abstract: Thirty-six compounds, representing six different structural classes of insecticides which are known to act at the γ-aminobutyric acid receptor/chloride ionophore, have been superimposed by methods which maximise the commonality of steric and electrostatic fields. Maximal steric and electrostatic alignment was derived by pairwise comparisons of the different chemical classes with picrotoxinin. To test the validity of the combined superposition, a Comparative Molecular Field Analysis (CoMFA) was carried out within SYBYL, using recently published in vivo and in vitro binding data for insecticides. The resultant partial least-squares (PLS) analysis of sampled steric and electrostatic fields showed a significant statistical correlation with the published biological data. The predictive model obtained was shown to have a greater than 95% chance of significance.
29 citations
Authors
Showing all 1888 results
Name | H-index | Papers | Citations |
---|---|---|---|
Fernand Labrie | 110 | 885 | 48308 |
Lionel H. Opie | 84 | 519 | 25964 |
Alain Bélanger | 70 | 244 | 16469 |
Michel J. Tremblay | 53 | 273 | 10485 |
Pierre Monsan | 51 | 216 | 8049 |
Samir Z. Zard | 50 | 575 | 10739 |
Alejandro Aruffo | 47 | 123 | 14084 |
Samuel S.C. Yen | 47 | 96 | 6865 |
Dominique Maraninchi | 47 | 188 | 8108 |
Serge Erlinger | 46 | 152 | 8200 |
Romain Lefebvre | 40 | 221 | 5269 |
William B. Motherwell | 39 | 305 | 6357 |
Jean-Pierre Raynaud | 38 | 104 | 5075 |
André Lemay | 38 | 114 | 4264 |
Patrick J. Creaven | 32 | 102 | 3435 |