University of Alberta

About: University of Alberta is a education organization based out in Edmonton, Alberta, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 65403 authors who have published 154847 publications receiving 5358338 citations. The organization is also known as: Ualberta & UAlberta.

Granular Computing: Analysis and Design of Intelligent Systems

Abstract: Information granules, as encountered in natural language, are implicit in nature. To make them fully operational so they can be effectively used to analyze and design intelligent systems, information granules need to be made explicit. An emerging discipline, granular computing focuses on formalizing information granules and unifying them to create a coherent methodological and developmental environment for intelligent system design and analysis. Granular Computing: Analysis and Design of Intelligent Systems presents the unified principles of granular computing along with its comprehensive algorithmic framework and design practices. Introduces the concepts of information granules, information granularity, and granular computing Presents the key formalisms of information granules Builds on the concepts of information granules with discussion of higher-order and higher-type information granules Discusses the operational concept of information granulation and degranulation by highlighting the essence of this tandem and its quantification in terms of the associated reconstruction error Examines the principle of justifiable granularity Stresses the need to look at information granularity as an important design asset that helps construct more realistic models of real-world systems or facilitate collaborative pursuits of system modeling Highlights the concepts, architectures, and design algorithms of granular models Explores application domains where granular computing and granular models play a visible role, including pattern recognition, time series, and decision making Written by an internationally renowned authority in the field, this innovative book introduces readers to granular computing as a new paradigm for the analysis and synthesis of intelligent systems. It is a valuable resource for those engaged in research and practical developments in computer, electrical, industrial, manufacturing, and biomedical engineering. Building from fundamentals, the book is also suitable for readers from nontechnical disciplines where information granules assume a visible position.

Neglecting legumes has compromised human health and sustainable food production

Abstract: The United Nations declared 2016 as the International Year of Pulses (grain legumes) under the banner ‘nutritious seeds for a sustainable future’. A second green revolution is required to ensure food and nutritional security in the face of global climate change. Grain legumes provide an unparalleled solution to this problem because of their inherent capacity for symbiotic atmospheric nitrogen fixation, which provides economically sustainable advantages for farming. In addition, a legume-rich diet has health benefits for humans and livestock alike. However, grain legumes form only a minor part of most current human diets, and legume crops are greatly under-used. Food security and soil fertility could be significantly improved by greater grain legume usage and increased improvement of a range of grain legumes. The current lack of coordinated focus on grain legumes has compromised human health, nutritional security and sustainable food production.

Alterations in intestinal permeability

Abstract: The goal of this review is to describe barrier function of the intestine, the structure of the tight junction, methods to evaluate intestinal permeability, and most importantly the relevance of abnormal permeability to disease. In this context, we will also present an emerging paradigm regarding the genesis of autoimmune diseases and describe the data that supports this from the perspective of both human disease and animal models. While this is a complicated area there are several points worth remembering: From the lower oesophageal sphincter to the anus, the gastrointestinal tract has a single contiguous layer of cells that separates the inside of the body from the external environment. Separation is important as there are a wide variety of environmental agents in the lumen of the bowel that can initiate or perpetuate mucosal inflammation if they cross the epithelial barrier. While the epithelial lining of the intestine plays a critical role in preventing access of these agents, it is not the only component of what is termed barrier function. Also important are secreted products such as immunoglobulin, mucous, defensins, and other antimicrobial products. The importance of epithelial barrier function in normal homeostasis can be appreciated from experiments performed in the early 1990s where cell wall extracts from luminal bacteria were injected into the colonic wall of rats.1 This simple manoeuvre of bypassing the epithelial barrier and placing luminal compounds directly into the colonic wall initiated an …