University of Alberta

About: University of Alberta is a education organization based out in Edmonton, Alberta, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 65403 authors who have published 154847 publications receiving 5358338 citations. The organization is also known as: Ualberta & UAlberta.

The diploid genome sequence of an Asian individual.

Abstract: Here we present the first diploid genome sequence of an Asian individual. The genome was sequenced to 36-fold average coverage using massively parallel sequencing technology. We aligned the short reads onto the NCBI human reference genome to 99.97% coverage, and guided by the reference genome, we used uniquely mapped reads to assemble a high-quality consensus sequence for 92% of the Asian individual's genome. We identified approximately 3 million single-nucleotide polymorphisms (SNPs) inside this region, of which 13.6% were not in the dbSNP database. Genotyping analysis showed that SNP identification had high accuracy and consistency, indicating the high sequence quality of this assembly. We also carried out heterozygote phasing and haplotype prediction against HapMap CHB and JPT haplotypes (Chinese and Japanese, respectively), sequence comparison with the two available individual genomes (J. D. Watson and J. C. Venter), and structural variation identification. These variations were considered for their potential biological impact. Our sequence data and analyses demonstrate the potential usefulness of next-generation sequencing technologies for personal genomics.

Scientists' Warning to Humanity: Microorganisms and Climate Change

Abstract: In the Anthropocene, in which we now live, climate change is impacting most life on Earth. Microorganisms support the existence of all higher trophic life forms. To understand how humans and other life forms on Earth (including those we are yet to discover) can withstand anthropogenic climate change, it is vital to incorporate knowledge of the microbial 'unseen majority'. We must learn not just how microorganisms affect climate change (including production and consumption of greenhouse gases) but also how they will be affected by climate change and other human activities. This Consensus Statement documents the central role and global importance of microorganisms in climate change biology. It also puts humanity on notice that the impact of climate change will depend heavily on responses of microorganisms, which are essential for achieving an environmentally sustainable future.

Meta-Analysis: Secondary Prevention Programs for Patients with Coronary Artery Disease

Abstract: The authors reviewed 63 randomized trials that measured the effect of adding an exercise program to secondary cardiac prevention programs. Programs that promoted exercise reduced all-cause mortalit...

BASNet: Boundary-Aware Salient Object Detection

Abstract: Deep Convolutional Neural Networks have been adopted for salient object detection and achieved the state-of-the-art performance. Most of the previous works however focus on region accuracy but not on the boundary quality. In this paper, we propose a predict-refine architecture, BASNet, and a new hybrid loss for Boundary-Aware Salient object detection. Specifically, the architecture is composed of a densely supervised Encoder-Decoder network and a residual refinement module, which are respectively in charge of saliency prediction and saliency map refinement. The hybrid loss guides the network to learn the transformation between the input image and the ground truth in a three-level hierarchy -- pixel-, patch- and map- level -- by fusing Binary Cross Entropy (BCE), Structural SIMilarity (SSIM) and Intersection-over-Union (IoU) losses. Equipped with the hybrid loss, the proposed predict-refine architecture is able to effectively segment the salient object regions and accurately predict the fine structures with clear boundaries. Experimental results on six public datasets show that our method outperforms the state-of-the-art methods both in terms of regional and boundary evaluation measures. Our method runs at over 25 fps on a single GPU. The code is available at: https://github.com/NathanUA/BASNet.