Institution
University of Alberta
Education•Edmonton, Alberta, Canada•
About: University of Alberta is a education organization based out in Edmonton, Alberta, Canada. It is known for research contribution in the topics: Population & Health care. The organization has 65403 authors who have published 154847 publications receiving 5358338 citations. The organization is also known as: Ualberta & UAlberta.
Papers published on a yearly basis
Papers
More filters
••
Aarhus University1, Pennsylvania State University2, University of Alaska Fairbanks3, Abisko Scientific Research Station4, University of Sheffield5, Lund University6, University Centre in Svalbard7, University of Copenhagen8, University of Helsinki9, University of Alberta10, University of Washington11, Canadian Wildlife Service12, University of Aberdeen13, University of Alaska Anchorage14, University of Stirling15
TL;DR: These rapid changes in terrestrial, freshwater, and marine systems, presage changes at lower latitudes that will affect natural resources, food production, and future climate buffering, and highlight areas of ecological research that deserve priority as the Arctic continues to warm.
Abstract: At the close of the Fourth International Polar Year, we take stock of the ecological consequences of recent climate change in the Arctic, focusing on effects at population, community, and ecosystem scales. Despite the buffering effect of landscape heterogeneity, Arctic ecosystems and the trophic relationships that structure them have been severely perturbed. These rapid changes may be a bellwether of changes to come at lower latitudes and have the potential to affect ecosystem services related to natural resources, food production, climate regulation, and cultural integrity. We highlight areas of ecological research that deserve priority as the Arctic continues to warm.
1,157 citations
••
TL;DR: The authors have observed a growth in the number of qualitative studies that have no guiding set of philosophic assumptions in the form of one of the established qualitative methodologies, and they encourage such debate and offer four basic requirements as a point of departure: noting the researchers' position, distinguishing method and methodology, making explicit the approach to rigor, and identifying the researchers's analytic lens.
Abstract: We have observed a growth in the number of qualitative studies that have no guiding set of philosophic assumptions in the form of one of the established qualitative methodologies. This lack of allegiance to an established qualitative approach presents many challenges for "generic qualitative" studies, one of which is that the literature lacks debate about how to do a generic study well. We encourage such debate and offer four basic requirements as a point of departure: noting the researchers’ position, distinguishing method and methodology, making explicit the approach to rigor, and identifying the researchers’ analytic lens.
1,157 citations
••
TL;DR: It is shown that moderate mtDNA stress elicited by TFAM deficiency engages cytosolic antiviral signalling to enhance the expression of a subset of interferon-stimulated genes, and it is suggested that cellular monitoring of mtDNA homeostasis cooperates with canonical virus sensing mechanisms to fully engage antiviral innate immunity.
Abstract: Mitochondrial DNA (mtDNA) is normally present at thousands of copies per cell and is packaged into several hundred higher-order structures termed nucleoids The abundant mtDNA-binding protein TFAM (transcription factor A, mitochondrial) regulates nucleoid architecture, abundance and segregation Complete mtDNA depletion profoundly impairs oxidative phosphorylation, triggering calcium-dependent stress signalling and adaptive metabolic responses However, the cellular responses to mtDNA instability, a physiologically relevant stress observed in many human diseases and ageing, remain poorly defined Here we show that moderate mtDNA stress elicited by TFAM deficiency engages cytosolic antiviral signalling to enhance the expression of a subset of interferon-stimulated genes Mechanistically, we find that aberrant mtDNA packaging promotes escape of mtDNA into the cytosol, where it engages the DNA sensor cGAS (also known as MB21D1) and promotes STING (also known as TMEM173)-IRF3-dependent signalling to elevate interferon-stimulated gene expression, potentiate type I interferon responses and confer broad viral resistance Furthermore, we demonstrate that herpesviruses induce mtDNA stress, which enhances antiviral signalling and type I interferon responses during infection Our results further demonstrate that mitochondria are central participants in innate immunity, identify mtDNA stress as a cell-intrinsic trigger of antiviral signalling and suggest that cellular monitoring of mtDNA homeostasis cooperates with canonical virus sensing mechanisms to fully engage antiviral innate immunity
1,157 citations
••
Université de Sherbrooke1, University of Alberta2, University of Lapland3, University of Victoria4, Wageningen University and Research Centre5, University of Alaska Fairbanks6, University of Oxford7, Université du Québec à Trois-Rivières8, Laval University9, St. John's University10, University of Amsterdam11, University of Vermont12, Aarhus University13, University of Zurich14, Swiss Federal Institute for Forest, Snow and Landscape Research15, University of Edinburgh16, La Trobe University17, Woods Hole Oceanographic Institution18, Lamont–Doherty Earth Observatory19, University of British Columbia20, University of Tromsø21, University of Alaska Anchorage22, Queen's University23, University of Virginia24
TL;DR: This article used repeat photography, long-term ecological monitoring and dendrochronology to document shrub expansion in arctic, high-latitude and alpine tundra.
Abstract: Recent research using repeat photography, long-term ecological monitoring and dendrochronology has documented shrub expansion in arctic, high-latitude and alpine tundra
1,153 citations
01 Feb 2014
TL;DR: Chronos and Chrimson as mentioned in this paper have been shown to enable two-color activation of neural spiking and downstream synaptic transmission in independent neural populations without detectable cross-talk in mouse brain slice.
Abstract: Optogenetic tools enable examination of how specific cell types contribute to brain circuit functions. A long-standing question is whether it is possible to independently activate two distinct neural populations in mammalian brain tissue. Such a capability would enable the study of how different synapses or pathways interact to encode information in the brain. Here we describe two channelrhodopsins, Chronos and Chrimson, discovered through sequencing and physiological characterization of opsins from over 100 species of alga. Chrimson's excitation spectrum is red shifted by 45 nm relative to previous channelrhodopsins and can enable experiments in which red light is preferred. We show minimal visual system-mediated behavioral interference when using Chrimson in neurobehavioral studies in Drosophila melanogaster. Chronos has faster kinetics than previous channelrhodopsins yet is effectively more light sensitive. Together these two reagents enable two-color activation of neural spiking and downstream synaptic transmission in independent neural populations without detectable cross-talk in mouse brain slice.
1,152 citations
Authors
Showing all 66027 results
Name | H-index | Papers | Citations |
---|---|---|---|
Salim Yusuf | 231 | 1439 | 252912 |
Yi Chen | 217 | 4342 | 293080 |
Robert M. Califf | 196 | 1561 | 167961 |
Douglas R. Green | 182 | 661 | 145944 |
Russel J. Reiter | 169 | 1646 | 121010 |
Jiawei Han | 168 | 1233 | 143427 |
Jaakko Kaprio | 163 | 1532 | 126320 |
Tobin J. Marks | 159 | 1621 | 111604 |
Josef M. Penninger | 154 | 700 | 107295 |
Subir Sarkar | 149 | 1542 | 144614 |
Gerald M. Edelman | 147 | 545 | 69091 |
Rinaldo Bellomo | 147 | 1714 | 120052 |
P. Sinervo | 138 | 1516 | 99215 |
David A. Jackson | 136 | 1095 | 68352 |
Andreas Warburton | 135 | 1578 | 97496 |