Institution
University of Colorado Denver
Education•Denver, Colorado, United States•
About: University of Colorado Denver is a education organization based out in Denver, Colorado, United States. It is known for research contribution in the topics: Population & Health care. The organization has 27444 authors who have published 57213 publications receiving 2539937 citations. The organization is also known as: CU Denver & UCD.
Topics: Population, Health care, Poison control, Medicine, Diabetes mellitus
Papers published on a yearly basis
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TL;DR: Recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression is reviewed, including the act of lnc RNA transcription rather than the lncRNA product that appears to be regulatory.
Abstract: It has recently become apparent that RNA, itself the product of transcription, is a major regulator of the transcriptional process. In particular, long noncoding RNAs (lncRNAs), which are so numerous in eukaryotes, function in many cases as transcriptional regulators. These RNAs function through binding to histone-modifying complexes, to DNA binding proteins (including transcription factors), and even to RNA polymerase II. In other cases, it is the act of lncRNA transcription rather than the lncRNA product that appears to be regulatory. We review recent progress in elucidating the molecular mechanisms by which lncRNAs modulate gene expression and future opportunities in this research field.
473 citations
Broad Institute1, North Carolina State University2, University of Oxford3, Stanford University4, University of Rochester5, Mississippi State University6, City University of New York7, College of Charleston8, Harvard University9, University of Colorado Denver10, Indiana University11, Children's Hospital Oakland Research Institute12, University of California, Santa Cruz13, University of New Mexico14, Smithsonian Institution15, Wellcome Trust Sanger Institute16, Michigan State University17, University of Georgia18, Boston University19, University of North Carolina at Chapel Hill20, Uppsala University21
TL;DR: The evolution of the amniotic egg was one of the great evolutionary innovations in the history of life, freeing vertebrates from an obligatory connection to water and thus permitting the conquest of terrestrial environments as discussed by the authors.
Abstract: The evolution of the amniotic egg was one of the great evolutionary innovations in the history of life, freeing vertebrates from an obligatory connection to water and thus permitting the conquest of terrestrial environments 1 . Among amniotes, genome sequences are available for mammals and birds 2–4 , but not for non-avian
473 citations
TL;DR: A unified model in which immune tolerance to β cells can be broken by several environmental exposures that induce generation of hybrid peptides acting as neoautoantigens is suggested.
473 citations
University of California, Irvine1, Veterans Health Administration2, National Institutes of Health3, Virginia Commonwealth University4, University of Colorado Denver5, University of Texas Southwestern Medical Center6, Saint Louis University7, Carolinas Medical Center8, University of Connecticut9, Harvard University10, University of Washington11, University of Southern California12, University of Michigan13
TL;DR: Patients with advanced chronic hepatitis C who achieved SVR had a marked reduction in death/liver transplantation, and in liver‐related morbidity/mortality, although they remain at risk for HCC.
472 citations
TL;DR: This study investigated the safety of a hybrid closed-loop system in patients with type 1 diabetes and found it feasible to automatically adjust insulin delivery based on subcutaneous sensor data to improve diabetes management.
Abstract: Safety of a Hybrid Closed-Loop Insulin Delivery System in Patients With Type 1 Diabetes Closed-loopartificialpancreastechnologyusesacontrolalgorithm to automatically adjust insulin delivery based on subcutaneous sensor data to improve diabetes management. Currently available systems stop insulin in response to existing1 or predicted2 low sensor glucose values, whereas hybrid closed-loop systems combine user-delivered premeal boluses with automatic interprandial insulin delivery.3 This study investigated the safety of a hybrid closed-loop system in patients with type 1 diabetes.
471 citations
Authors
Showing all 27683 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Matthew Meyerson | 194 | 553 | 243726 |
| Charles A. Dinarello | 190 | 1058 | 139668 |
| Gad Getz | 189 | 520 | 247560 |
| Gordon B. Mills | 187 | 1273 | 186451 |
| Jasvinder A. Singh | 176 | 2382 | 223370 |
| David Haussler | 172 | 488 | 224960 |
| Donald G. Truhlar | 165 | 1518 | 157965 |
| Charles M. Perou | 156 | 573 | 202951 |
| David Cella | 156 | 1258 | 106402 |
| Bruce D. Walker | 155 | 779 | 86020 |
| Marco A. Marra | 153 | 620 | 184684 |
| Thomas E. Starzl | 150 | 1625 | 91704 |
| Marc Humbert | 149 | 1184 | 100577 |
| Rajesh Kumar | 149 | 4439 | 140830 |
| Martin J. Blaser | 147 | 820 | 104104 |