University of Tübingen

About: University of Tübingen is a education organization based out in Tübingen, Germany. It is known for research contribution in the topics: Population & Immune system. The organization has 40555 authors who have published 84108 publications receiving 3015320 citations. The organization is also known as: Eberhard Karls University & Eberhard-Karls-Universität Tübingen.

Regimes of youth transitions Choice, flexibility and security in young people’s experiences across different European contexts

Abstract: In a context of de-standardized transitions to work, young people are required to take more individual decisions, a process in which their subjectivities become increasingly important for social in...

Cep164, a novel centriole appendage protein required for primary cilium formation

Abstract: Primary cilia (PC) function as microtubule-based sensory antennae projecting from the surface of many eukaryotic cells. They play important roles in mechano- and chemosensory perception and their dysfunction is implicated in developmental disorders and severe diseases. The basal body that functions in PC assembly is derived from the mature centriole, a component of the centrosome. Through a small interfering RNA screen we found several centrosomal proteins (Ceps) to be involved in PC formation. One newly identified protein, Cep164, was indispensable for PC formation and hence characterized in detail. By immunogold electron microscopy, Cep164 could be localized to the distal appendages of mature centrioles. In contrast to ninein and Cep170, two components of subdistal appendages, Cep164 persisted at centrioles throughout mitosis. Moreover, the localizations of Cep164 and ninein/Cep170 were mutually independent during interphase. These data implicate distal appendages in PC formation and identify Cep164 as an excellent marker for these structures.

Bereavement and Health: The Psychological and Physical Consequences of Partner Loss

Abstract: Does the popular notion of a 'broken heart' have some grounding in reality? How can grief affect the body in ways that necessitate medical care and may even be life-threatening? Bereavement and Health constitutes a comprehensive review of what is known about the impact of bereavement on surviving partners. Drawing on the work of psychologists, sociologists, epidemiologists, and psychiatrists, Wolfgang and Margaret Stroebe offer a theoretically coherent perspective focused on conjugal loss. After a thorough discussion of stress and depression models of bereavement, the authors present their own theoretical approach, emphasizing social contacts and the interpersonal nature of grief. They then examine the psychological and medical consequences of bereavement: Are the bereaved at higher risk than those who have not lost a partner? What has research revealed about the causes, symptoms, and outcomes of grief? Key questions about recovery from grief are also addressed: Is the health risk of bereavement severe enough to have lasting or even fatal consequences? Is it possible to identify those bereaved who are at high risk before their health suffers? What are the strategies that are most likely to lead to effective coping? Can attempts at intervention be effective? The Stroebes' combination of theoretical integration and methodological rigor will make Bereavement and Health a standard text for years to come.