Institution
University of Tübingen
Education•Tübingen, Germany•
About: University of Tübingen is a education organization based out in Tübingen, Germany. It is known for research contribution in the topics: Population & Immune system. The organization has 40555 authors who have published 84108 publications receiving 3015320 citations. The organization is also known as: Eberhard Karls University & Eberhard-Karls-Universität Tübingen.
Topics: Population, Immune system, Transplantation, Context (language use), Gene
Papers published on a yearly basis
Papers
More filters
••
TL;DR: These findings uncover a unique strategy of bacterial pathogenesis where virulence effectors block signal transmission through a key common component of multiple MAMP-receptor complexes.
539 citations
••
TL;DR: A new vector series is designed, and a large number of stably transformed plants expressing membrane protein fusions to spectrally distinct, fluorescent tags are generated, demonstrating the power of this multicolor 'Wave' marker set for rapid, combinatorial analysis of plant cell membrane compartments, both in live-imaging and immunoelectron microscopy.
Abstract: Plant membrane compartments and trafficking pathways are highly complex, and are often distinct from those of animals and fungi. Progress has been made in defining trafficking in plants using transient expression systems. However, many processes require a precise understanding of plant membrane trafficking in a developmental context, and in diverse, specialized cell types. These include defense responses to pathogens, regulation of transporter accumulation in plant nutrition or polar auxin transport in development. In all of these cases a central role is played by the endosomal membrane system, which, however, is the most divergent and ill-defined aspect of plant cell compartmentation. We have designed a new vector series, and have generated a large number of stably transformed plants expressing membrane protein fusions to spectrally distinct, fluorescent tags. We selected lines with distinct subcellular localization patterns, and stable, non-toxic expression. We demonstrate the power of this multicolor 'Wave' marker set for rapid, combinatorial analysis of plant cell membrane compartments, both in live-imaging and immunoelectron microscopy. Among other findings, our systematic co-localization analysis revealed that a class of plant Rab1-homologs has a much more extended localization than was previously assumed, and also localizes to trans-Golgi/endosomal compartments. Constructs that can be transformed into any genetic background or species, as well as seeds from transgenic Arabidopsis plants, will be freely available, and will promote rapid progress in diverse areas of plant cell biology.
539 citations
••
Free University of Berlin1, Max Planck Society2, University of Colorado Boulder3, University of Oxford4, University of Ioannina5, Royal Berkshire NHS Foundation Trust6, Harvard University7, Mayo Clinic8, University of Miami9, University of Tübingen10, German Center for Neurodegenerative Diseases11, Boston University12, Emory University13, University of British Columbia14, Indiana University15, Wadsworth Center16, University College London17, VU University Amsterdam18, University of Lübeck19, University of Chicago20, University of Toulouse21, Centre national de la recherche scientifique22, National Institutes of Health23, Kobe University24, deCODE genetics25, University of Washington26, University of Münster27, Centers for Disease Control and Prevention28, University of Mainz29
TL;DR: This study provides an exhaustive and up-to-date summary of the status of PD genetics research that can be readily scaled to include the results of future large-scale genetics projects, including next-generation sequencing studies.
Abstract: More than 800 published genetic association studies have implicated dozens of potential risk loci in Parkinson’s disease (PD). To facilitate the interpretation of these findings, we have created a dedicated online resource, PDGene, that comprehensively collects and meta-analyzes all published studies in the field. A systematic literature screen of ,27,000 articles yielded 828 eligible articles from which relevant data were extracted. In addition, individual-level data from three publicly available genome-wide association studies (GWAS) were obtained and subjected to genotype imputation and analysis. Overall, we performed meta-analyses on more than seven million polymorphisms originating either from GWAS datasets and/or from smaller scale PD association studies. Metaanalyses on 147 SNPs were supplemented by unpublished GWAS data from up to 16,452 PD cases and 48,810 controls. Eleven loci showed genome-wide significant (P,5610 28 ) association with disease risk: BST1, CCDC62/HIP1R, DGKQ/GAK, GBA, LRRK2, MAPT, MCCC1/LAMP3 ,P ARK16,SNCA, STK39 ,a ndSYT11/RAB25. In addition, we identified novel evidence for genome-wide significant association with a polymorphism in ITGA8 (rs7077361, OR 0.88, P=1.3610 28 ). All meta-analysis results are freely available on a dedicated online database (www.pdgene.org), which is cross-linked with a customized track on the UCSC Genome Browser. Our study provides an exhaustive and up-to-date summary of the status of PD genetics research that can be readily scaled to include the results of future large-scale genetics projects, including next-generation sequencing studies.
537 citations
••
Agro ParisTech1, Institut national de la recherche agronomique2, University of Florida3, Goddard Institute for Space Studies4, University of Basilicata5, Michigan State University6, Wageningen University and Research Centre7, Empresa Brasileira de Pesquisa Agropecuária8, University of East Anglia9, University of Tübingen10, University of Nebraska–Lincoln11, United States Department of Agriculture12, Pacific Northwest National Laboratory13, Pennsylvania State University14, University of Washington15, Indian Agricultural Research Institute16, Potsdam Institute for Climate Impact Research17, Chinese Academy of Sciences18, Plant & Food Research19
TL;DR: The largest maize crop model intercomparison to date, including 23 different models, is presented, suggesting that using an ensemble of models has merit and there was a large uncertainty in the yield response to [CO2 ] among models.
Abstract: Potential consequences of climate change on crop production can be studied using mechanistic crop simulation models. While a broad variety of maize simulation models exist, it is not known whether different models diverge on grain yield responses to changes in climatic factors, or whether they agree in their general trends related to phenology, growth, and yield. With the goal of analyzing the sensitivity of simulated yields to changes in temperature and atmospheric carbon dioxide concentrations [CO2], we present the largest maize crop model intercomparison to date, including 23 different models. These models were evaluated for four locations representing a wide range of maize production conditions in the world: Lusignan (France), Ames (USA), Rio Verde (Brazil) and Morogoro (Tanzania). While individual models differed considerably in absolute yield simulation at the four sites, an ensemble of a minimum number of models was able to simulate absolute yields accurately at the four sites even with low data for calibration, thus suggesting that using an ensemble of models has merit. Temperature increase had strong negative influence on modeled yield response of roughly -0.5 Mg ha(-1) per degrees C. Doubling [CO2] from 360 to 720 mu mol mol(-1) increased grain yield by 7.5% on average across models and the sites. That would therefore make temperature the main factor altering maize yields at the end of this century. Furthermore, there was a large uncertainty in the yield response to [CO2] among models. Model responses to temperature and [CO2] did not differ whether models were simulated with low calibration information or, simulated with high level of calibration information.
536 citations
••
Commonwealth Scientific and Industrial Research Organisation1, University of Tübingen2, Tel Aviv University3, Washington State University4, University of São Paulo5, World Agroforestry Centre6, Zhejiang University7, Swedish University of Agricultural Sciences8, Université catholique de Louvain9, McGill University10, SupAgro11, Wageningen University and Research Centre12, Karlsruhe Institute of Technology13, Finnish Environment Institute14, Czech University of Life Sciences Prague15, Chinese Academy of Sciences16, Agrocampus Ouest17, Gembloux Agro-Bio Tech18, University of Florida19, Universidad Miguel Hernández de Elche20, Landcare Research21, Aarhus University22, International Trademark Association23, University of Northern British Columbia24, University of Molise25, Agricultural Research Service26, British Geological Survey27, Rural Development Administration28
TL;DR: In this article, the authors developed and analyzed a global soil visible-near infrared (vis-NIR) spectral library, which is currently the largest and most diverse database of its kind, and showed that the information encoded in the spectra can describe soil composition and be associated to land cover and its global geographic distribution, which acts as a surrogate for global climate variability.
535 citations
Authors
Showing all 41039 results
Name | H-index | Papers | Citations |
---|---|---|---|
John Q. Trojanowski | 226 | 1467 | 213948 |
Lily Yeh Jan | 162 | 467 | 73655 |
Monique M.B. Breteler | 159 | 546 | 93762 |
Wolfgang Wagner | 156 | 2342 | 123391 |
Thomas Meitinger | 155 | 716 | 108491 |
Hermann Brenner | 151 | 1765 | 145655 |
Amartya Sen | 149 | 689 | 141907 |
Bernhard Schölkopf | 148 | 1092 | 149492 |
Niels Birbaumer | 142 | 835 | 77853 |
Detlef Weigel | 142 | 516 | 84670 |
Peter Lang | 140 | 1136 | 98592 |
Marco Colonna | 139 | 512 | 71166 |
António Amorim | 136 | 1477 | 96519 |
Alexis Brice | 135 | 870 | 83466 |
Elias Campo | 135 | 761 | 85160 |