Institution
University of Tübingen
Education•Tübingen, Germany•
About: University of Tübingen is a education organization based out in Tübingen, Germany. It is known for research contribution in the topics: Population & Immune system. The organization has 40555 authors who have published 84108 publications receiving 3015320 citations. The organization is also known as: Eberhard Karls University & Eberhard-Karls-Universität Tübingen.
Topics: Population, Immune system, Transplantation, Context (language use), Gene
Papers published on a yearly basis
Papers
More filters
••
TL;DR: In this paper, the effects of diffusion on the non-linear corotation torque, or horseshoe drag, in the two-dimensional limit, focusing on low-mass planets for which the width of the horshoe region is much smaller than the scaleheight of the disc.
Abstract: We study the effects of diffusion on the non-linear corotation torque, or horseshoe drag, in the two-dimensional limit, focusing on low-mass planets for which the width of the horseshoe region is much smaller than the scaleheight of the disc. In the absence of diffusion, the non-linear corotation torque saturates, leaving only the Lindblad torque. Diffusion of heat and momentum can act to sustain the corotation torque. In the limit of very strong diffusion, the linear corotation torque is recovered. For the case of thermal diffusion, this limit corresponds to having a locally isothermal equation of state. We present some simple models that are able to capture the dependence of the torque on diffusive processes to within 20 per cent of the numerical simulations.
469 citations
••
TL;DR: A new perspective is emerging, in which the control of apoptosis by Bax and Bak goes beyond them and is highly influenced by additional mitochondrial components, and the contribution of mitochondrial composition, dynamics and interaction with other organelles to apoptosis commitment is considered.
Abstract: Bax and Bak are members of the Bcl-2 family and core regulators of the intrinsic pathway of apoptosis. Upon apoptotic stimuli, they are activated and oligomerize at the mitochondrial outer membrane (MOM) to mediate its permeabilization, which is considered a key step in apoptosis. However, the molecular mechanism underlying Bax and Bak function has remained a key question in the field. Here, we review recent structural and biophysical evidence that has changed our understanding of how Bax and Bak promote MOM permeabilization. We also discuss how the spatial regulation of Bcl-2 family preference for binding partners contributes to regulate Bax and Bak activation. Finally, we consider the contribution of mitochondrial composition, dynamics and interaction with other organelles to apoptosis commitment. A new perspective is emerging, in which the control of apoptosis by Bax and Bak goes beyond them and is highly influenced by additional mitochondrial components.
467 citations
••
University of Antwerp1, Radboud University Nijmegen2, Medical University of Warsaw3, University of Padua4, University of Milan5, Innsbruck Medical University6, Charles University in Prague7, Harvard University8, Ankara University9, University of Melbourne10, Royal Children's Hospital11, University College London12, Tel Aviv University13, University of Tübingen14, University of Debrecen15, Boys Town16, University of Oulu17, University of Copenhagen18, Stanford University19, University of Ferrara20, University of Lisbon21, Johnson & Johnson Pharmaceutical Research and Development22, University of Iowa23
TL;DR: The association between genotype and degree of hearing loss in persons with HI and biallelic GJB2 mutations was assessed and two genotypes had significantly more-severe HI than that of 35delG homozygotes.
Abstract: Hearing impairment (HI) affects 1 in 650 newborns, which makes it the most common congenital sensory impairment. Despite extraordinary genetic heterogeneity, mutations in one gene, GJB2, which encodes the connexin 26 protein and is involved in inner ear homeostasis, are found in up to 50% of patients with autosomal recessive nonsyndromic hearing loss. Because of the high frequency of GJB2 mutations, mutation analysis of this gene is widely available as a diagnostic test. In this study, we assessed the association between genotype and degree of hearing loss in persons with HI and biallelic GJB2 mutations. We performed cross-sectional analyses of GJB2 genotype and audiometric data from 1,531 persons, from 16 different countries, with autosomal recessive, mild-to-profound nonsyndromic HI. The median age of all participants was 8 years; 90% of persons were within the age range of 0-26 years. Of the 83 different mutations identified, 47 were classified as nontruncating, and 36 as truncating. A total of 153 different genotypes were found, of which 56 were homozygous truncating (T/T), 30 were homozygous nontruncating (NT/NT), and 67 were compound heterozygous truncating/nontruncating (T/NT). The degree of HI associated with biallelic truncating mutations was significantly more severe than the HI associated with biallelic nontruncating mutations (P<.0001). The HI of 48 different genotypes was less severe than that of 35delG homozygotes. Several common mutations (M34T, V37I, and L90P) were associated with mild-to-moderate HI (median 25-40 dB). Two genotypes--35delG/R143W (median 105 dB) and 35delG/dela(GJB6-D13S1830) (median 108 dB)--had significantly more-severe HI than that of 35delG homozygotes.
467 citations
••
TL;DR: Sucrose and its derivatives represent the major transport forms of photosynthetically assimilated carbon in plants and are exported via the phloem, the long-distance distribution network for assimilates.
Abstract: Sucrose and its derivatives represent the major transport forms of photosynthetically assimilated carbon in plants Sucrose synthesized in green leaves is exported via the phloem, the long-distance distribution network for assimilates, to supply nonphotosynthetic organs with energy and carbon
466 citations
••
TL;DR: Different approaches of mining genomes for secondary metabolites are focused, from detecting biosynthetic genes to resistance based methods and "evo-mining" strategies including a short evaluation of the impact of the development of genome mining methods and tools on the field of natural products and microbial ecology.
466 citations
Authors
Showing all 41039 results
Name | H-index | Papers | Citations |
---|---|---|---|
John Q. Trojanowski | 226 | 1467 | 213948 |
Lily Yeh Jan | 162 | 467 | 73655 |
Monique M.B. Breteler | 159 | 546 | 93762 |
Wolfgang Wagner | 156 | 2342 | 123391 |
Thomas Meitinger | 155 | 716 | 108491 |
Hermann Brenner | 151 | 1765 | 145655 |
Amartya Sen | 149 | 689 | 141907 |
Bernhard Schölkopf | 148 | 1092 | 149492 |
Niels Birbaumer | 142 | 835 | 77853 |
Detlef Weigel | 142 | 516 | 84670 |
Peter Lang | 140 | 1136 | 98592 |
Marco Colonna | 139 | 512 | 71166 |
António Amorim | 136 | 1477 | 96519 |
Alexis Brice | 135 | 870 | 83466 |
Elias Campo | 135 | 761 | 85160 |