Institution
University of Tübingen
Education•Tübingen, Germany•
About: University of Tübingen is a education organization based out in Tübingen, Germany. It is known for research contribution in the topics: Population & Immune system. The organization has 40555 authors who have published 84108 publications receiving 3015320 citations. The organization is also known as: Eberhard Karls University & Eberhard-Karls-Universität Tübingen.
Topics: Population, Immune system, Transplantation, Context (language use), Gene
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Harvard University1, University of Tübingen2, Max Planck Society3, Hungarian Academy of Sciences4, Howard Hughes Medical Institute5, University College Dublin6, University of Vienna7, University of Coimbra8, University of Ferrara9, University of Adelaide10, Trinity College, Dublin11, University of Cambridge12, Broad Institute13, Emory University14, University of Florence15, Bulgarian Academy of Sciences16, Danube Private University17, Romanian Academy18, Centre national de la recherche scientifique19, Eötvös Loránd University20, Sofia University21, University of Oxford22, University of Wyoming23, University of Zagreb24, Pennsylvania State University25, National Academy of Sciences of Ukraine26, Université de Montréal27, University of Bucharest28, Ludwig Maximilian University of Munich29, University of Edinburgh30, University of Wisconsin-Madison31, University of Palermo32, Croatian Academy of Sciences and Arts33, Naturhistorisches Museum34, Russian Academy of Sciences35, University of Toronto36, University of Latvia37, Durham University38, University of Hull39, Grand Valley State University40, Columbia University41
TL;DR: It is shown that southeastern Europe continued to be a nexus between east and west after the arrival of farmers, with intermittent genetic contact with steppe populations occurring up to 2,000 years earlier than the migrations from the steppe that ultimately replaced much of the population of northern Europe.
Abstract: Farming was first introduced to Europe in the mid-seventh millennium bc, and was associated with migrants from Anatolia who settled in the southeast before spreading throughout Europe. Here, to und ...
447 citations
TL;DR: The results show that high-affinity ammonium uptake in roots is regulated in relation to the physiological status of the plant at the transcriptional level and by substrate affinities of individual members of the AMT1 gene family.
Abstract: Ammonium and nitrate are the prevalent nitrogen sources for growth and development of higher plants. 15N-uptake studies demonstrated that ammonium is preferred up to 20-fold over nitrate by Arabidopsis plants. To study the regulation and complex kinetics of ammonium uptake, we isolated two new ammonium transporter (AMT) genes and showed that they functionally complemented an ammonium uptake-deficient yeast mutant. Uptake studies with 14C-methylammonium and inhibition by ammonium yielded distinct substrate affinities between
447 citations
Medical Research Council1, Harvard University2, Lund University3, University of Minnesota4, Duke University5, University of Oulu6, Novo Nordisk7, Technische Universität München8, University College London9, University of Lausanne10, University of Eastern Finland11, National University of Singapore12, King's College London13, University of Bristol14, George Washington University15, National Institutes of Health16, University of Bergen17, University of Michigan18, University of North Carolina at Chapel Hill19, University of Groningen20, Utrecht University21, University of Copenhagen22, Erasmus University Rotterdam23, University of Tübingen24, Harokopio University25, Washington University in St. Louis26, University of Maryland, Baltimore27, University of Granada28, Complutense University of Madrid29, University of Turku30, University of Southern Denmark31, Umeå University32, University of Gothenburg33, Laval University34, University of London35, Pennington Biomedical Research Center36, Lille University of Science and Technology37, Newcastle University38, University of Iceland39, Danube University Krems40, Broad Institute41, University of California, Los Angeles42, Hammersmith Hospital43, University of Cambridge44, National Institute for Health and Welfare45
TL;DR: In this paper, a meta-analysis of data from 45 studies of adults and nine studies of children and adolescents was conducted to confirm or refute unambiguously whether physical activity attenuates the association of FTO with obesity risk.
Abstract: Background: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n=218,166) and nine studies of children and adolescents (n=19,268). Methods and Findings: All studies identified to have data on the FTO rs9939609 variant (or any proxy [r(2)>0.8]) and PA were invited to participate, regardless of ethnicity or age of the participants. PA was standardized by categorizing it into a dichotomous variable (physically inactive versus active) in each study. Overall, 25% of adults and 13% of children were categorized as inactive. Interaction analyses were performed within each study by including the FTOxPA interaction term in an additive model, adjusting for age and sex. Subsequently, random effects meta-analysis was used to pool the interaction terms. In adults, the minor (A-) allele of rs9939609 increased the odds of obesity by 1.23-fold/allele (95% CI 1.20-1.26), but PA attenuated this effect (p(interaction) = 0.001). More specifically, the minor allele of rs9939609 increased the odds of obesity less in the physically active group (odds ratio = 1.22/allele, 95% CI 1.19-1.25) than in the inactive group (odds ratio = 1.30/allele, 95% CI 1.24-1.36). No such interaction was found in children and adolescents. Conclusions: The association of the FTO risk allele with the odds of obesity is attenuated by 27% in physically active adults, highlighting the importance of PA in particular in those genetically predisposed to obesity.
447 citations
TL;DR: A baseline signature of low LDH, AMC, and MDSCs as well as high AEC, Tregs, and RLC is associated with favorable outcome following ipilimumab.
Abstract: Purpose: To identify baseline peripheral blood biomarkers associated with clinical outcome following ipilimumab treatment in advanced melanoma patients. Experimental Design: Frequencies of myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg), serum lactate dehydrogenase (LDH), routine blood counts, and clinical characteristics were assessed in 209 patients. Endpoints were overall survival (OS) and best overall response. Statistical calculations were done by Kaplan–Meier and Cox regression analysis, including calibration and discrimination by C-statistics. Results: Low baseline LDH, absolute monocyte counts (AMC), Lin − CD14 + HLA-DR −/low -MDSC frequencies, and high absolute eosinophil counts (AEC), relative lymphocyte counts (RLC), and CD4 + CD25 + FoxP3 + -Treg frequencies were significantly associated with better survival, and were considered in a combination model. Patients (43.5%) presenting with the best biomarker signature had a 30% response rate and median survival of 16 months. In contrast, patients with the worst biomarkers (27.5%) had only a 3% response rate and median survival of 4 months. The occurrence of adverse events correlated with neither baseline biomarker signatures nor the clinical benefit of ipilimumab. In another model, limited to the routine parameters LDH, AMC, AEC, and RLC, the number of favorable factors (4 vs. 3 vs. 2–0) was also associated with OS ( P Conclusions: A baseline signature of low LDH, AMC, and MDSCs as well as high AEC, Tregs, and RLC is associated with favorable outcome following ipilimumab. Prospective investigation of the predictive impact of these markers following ipilimumab and other treatments, e.g., PD-1 antibodies, is warranted. Clin Cancer Res; 22(12); 2908–18. ©2016 AACR .
447 citations
TL;DR: This article found that the belief in a just world (BJW) is related to psychological well-being, and suggested that studies exploring this relationship might benefit by making the distinction between the BJW for self versus for others or in general.
Abstract: Studies have shown that the belief in a just world (BJW) is related to psychological well-being. The authors suggest that studies exploring this relationship might benefit by making the distinction between the BJW for self versus for others or in general. In two studies, the authors assessed subjects' perceptions of depression, stress, and life satisfaction for self and for others. Subjects also completed measures of the five-factor model of personality. As predicted, the BJW for self most strongly and consistently predicted decreases in depression and stress, and increases in life satisfaction. When the five personality dimensions were included in the analyses, the BJW for self and for others continued to predict life satisfaction but not depression and stress. The implications of these results concerning the relationship between the BJW and psychological well-being, and how the just world is conceptualized, are discussed.
447 citations
Authors
Showing all 41039 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| John Q. Trojanowski | 226 | 1467 | 213948 |
| Lily Yeh Jan | 162 | 467 | 73655 |
| Monique M.B. Breteler | 159 | 546 | 93762 |
| Wolfgang Wagner | 156 | 2342 | 123391 |
| Thomas Meitinger | 155 | 716 | 108491 |
| Hermann Brenner | 151 | 1765 | 145655 |
| Amartya Sen | 149 | 689 | 141907 |
| Bernhard Schölkopf | 148 | 1092 | 149492 |
| Niels Birbaumer | 142 | 835 | 77853 |
| Detlef Weigel | 142 | 516 | 84670 |
| Peter Lang | 140 | 1136 | 98592 |
| Marco Colonna | 139 | 512 | 71166 |
| António Amorim | 136 | 1477 | 96519 |
| Alexis Brice | 135 | 870 | 83466 |
| Elias Campo | 135 | 761 | 85160 |