2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines
Paul K. Whelton,Robert M. Carey,Wilbert S. Aronow,Donald E. Casey,Karen J. Collins,Cheryl Dennison Himmelfarb,Sondra M. DePalma,Samuel S. Gidding,Kenneth Jamerson,Daniel W. Jones,Eric J. MacLaughlin,Paul Muntner,Bruce Ovbiagele,Sidney C. Smith,Crystal C. Spencer,Randall S. Stafford,Sandra J. Taler,Randal J. Thomas,Kim A. Williams,Jeff D. Williamson,Jackson T. Wright +20 more
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Since 1980, the American College of Cardiology and American Heart Association have translated scientific evidence into clinical practice guidelines (guidelines) with recommendations to improve cardiovascular health.Abstract:
Since 1980, the American College of Cardiology (ACC) and American Heart Association (AHA) have translated scientific evidence into clinical practice guidelines (guidelines) with recommendations to improve cardiovascular health. In 2013, the National Heart, Lung, and Blood Institute (NHLBI) Advisoryread more
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Managing Clonal Hematopoiesis in Patients With Solid Tumors.
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Management of Traditional Cardiovascular Risk Factors in CKD: What Are the Data?
TL;DR: The best existing evidence and current clinical guidelines for modification of traditional risk factors for the prevention of CV events in patients with CKD are summarized and knowledge gaps are identified.
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Benefits and Harms of Antihypertensive Treatment in Low-Risk Patients With Mild Hypertension
James P Sheppard,Sarah Stevens,Richard Stevens,Una Martin,Jonathan Mant,Hobbs Fdr.,Richard J McManus +6 more
TL;DR: This prespecified analysis found no evidence to support guideline recommendations that encourage initiation of treatment in patients with low-risk mild hypertension, and there was evidence of an increased risk of adverse events, which suggests that physicians should exercise caution when following guidelines that generalize findings from trials conducted in high-risk individuals to those at lower risk.
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Effectiveness and safety of the tri-iodothyronine analogue Triac in children and adults with MCT8 deficiency: an international, single-arm, open-label, phase 2 trial
Stefan Groeneweg,Robin P. Peeters,Carla Moran,Athanasia Stoupa,Françoise Auriol,Davide Tonduti,Alice Dica,Laura Paone,Klara Rozenkova,Jana Malikova,Adri van der Walt,Irenaeus F.M. de Coo,Anne McGowan,Greta Lyons,Femke K. Aarsen,D Barca,Ingrid M. van Beynum,Marieke M. van der Knoop,Jurgen Jansen,Martien Manshande,Roelineke J. Lunsing,Stan Nowak,Corstiaan A. den Uil,M. Carola Zillikens,Frank E. Visser,Paul Vrijmoeth,Marie Claire Y. de Wit,Nicole I. Wolf,Angelique Zandstra,Gautam Ambegaonkar,Yogen Singh,Yolanda B. de Rijke,Marco Medici,Enrico Bertini,Sylvia Depoorter,Jan Lebl,Marco Cappa,Linda De Meirleir,Heiko Krude,Dana Craiu,Federica Zibordi,Isabelle Oliver Petit,Michel Polak,Krishna Chatterjee,Theo J. Visser,W. Edward Visser +45 more
TL;DR: This investigator-initiated, multicentre, open-label, single-arm, phase 2, pragmatic trial investigated the effectiveness and safety of oral Triac in male paediatric and adult patients with MCT8 deficiency in eight countries in Europe and one site in South Africa.
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Could 130/80 mm Hg Be Adopted as the Diagnostic Threshold and Management Goal of Hypertension in Consideration of the Characteristics of Asian Populations?
Kazuomi Kario,Ji-Guang Wang +1 more
TL;DR: The practical feasibility of the 2017 AHA/ACC guidelines for the management of hypertension and the ideal direction of blood pressure (BP) prevention, detection, evaluation, and management for achieving a goal of zero cardiovascular events in Asia is discussed.
References
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Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Bias in meta-analysis detected by a simple, graphical test
TL;DR: Funnel plots, plots of the trials' effect estimates against sample size, are skewed and asymmetrical in the presence of publication bias and other biases Funnel plot asymmetry, measured by regression analysis, predicts discordance of results when meta-analyses are compared with single large trials.
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The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report.
Aram V. Chobanian,George L. Bakris,Henry R. Black,William C. Cushman,Lee A. Green,Joseph L. Izzo,Daniel W. Jones,Barry J. Materson,Suzanne Oparil,Jackson T. Wright,Edward J. Roccella +10 more
TL;DR: The most effective therapy prescribed by the most careful clinician will control hypertension only if patients are motivated, and empathy builds trust and is a potent motivator.
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The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials
Julian P T Higgins,Douglas G. Altman,Peter C Gøtzsche,Peter Jüni,David Moher,Andrew D Oxman,Jelena Savović,Kenneth F. Schulz,Laura Weeks,Jonathan A C Sterne +9 more
TL;DR: The Cochrane Collaboration’s tool for assessing risk of bias aims to make the process clearer and more accurate.
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