2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk
Alison Halliday,Colin Baigent,François Mach,Borislava Mihaylova,Borislava Mihaylova,Brian A. Ference +5 more
TLDR
Authors/Task Force Members (François Macha, Colin Baigentb,∗∗,2, Alberico L. Catapanoc), ESC Committee for Practice Guidelines (CPG) (Stephan Windeckeraa), ESC National Cardiac Societies (Djamaleddine Nibouchean, Parounak H. Patelcl)About:
This article is published in Atherosclerosis.The article was published on 2019-09-02 and is currently open access. It has received 2972 citations till now. The article focuses on the topics: Lipid modification & Very low-density lipoprotein.read more
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Inclisiran for the Treatment of Cardiovascular Disease: A Short Review on the Emerging Data and Therapeutic Potential.
Constantine E Kosmas,Alba Munoz Estrella,Andreas Skavdis,Edilberto Peña Genao,Ian Martinez,Eliscer Guzman +5 more
TL;DR: Inclisiran offers an advantage against medication non-compliance, which is one of the main causes for not achieving LDL-C goals with standard therapy, and has a relatively safe profile with adverse effects occurring in similar frequency as with placebo.
Journal ArticleDOI
Statin use and mortality in COVID-19 patients: Updated systematic review and meta-analysis.
Anastasios Kollias,Konstantinos G. Kyriakoulis,Ioannis G. Kyriakoulis,Thomas Nitsotolis,Garyphallia Poulakou,George S. Stergiou,Konstantinos N. Syrigos +6 more
TL;DR: In this paper, a systematic review of published evidence regarding statin treatment and COVID-19 related mortality was performed, which showed that statin therapy was associated with an about 35% decrease in the adjusted risk of mortality in hospitalized COVID19 patients.
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Efficacy and Safety of Bempedoic Acid in Patients With Hypercholesterolemia: Systematic Review and Meta‐Analysis of Randomized Controlled Trials
Alessandro Di Minno,Roberta Lupoli,Ilenia Calcaterra,Paolo Poggio,Francesco Forte,Gaia Spadarella,Pasquale Ambrosino,Gabriella Iannuzzo,Matteo Nicola Dario Di Minno +8 more
TL;DR: A systematic review and meta‐analysis on efficacy and safety of BA compared with standard treatment in patients with hypercholesterolemia found that BA is associated with a significant reduction in low‐density lipoprotein cholesterol, total cholesterol, non–high‐density cholesterol, apolipoprotein B, and hs‐CRP compared withstandard treatment.
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What do we know about the role of lipoprotein(a) in atherogenesis 57 years after its discovery
TL;DR: Post hoc analyses of clinical trials with proprotein convertase subtilisin/kexin type-9 (PCSK9) inhibitors have shown that these drugs exert clinical benefits by lowering Lp(a), independent of their potent reduction of low-density lipoprotein cholesterol (LDL-C).
Journal ArticleDOI
Effects of Cardiovascular Risk Factor Variability on Health Outcomes
TL;DR: Recent evidence regarding the role of variability in metabolic parameters, which can be measured by continuous glucose monitoring systems or self-monitoring of blood glucose levels, is reviewed and the clinical implications of these findings are discussed.
References
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Atherosclerosis is an Inflammatory Disease
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TL;DR: Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.
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Massimo Piepoli,Arno W. Hoes,Stefan Agewall,Christian Albus,Carlos Brotons,Alberico L. Catapano,Marie Therese Cooney,Ugo Corrà,Bernard Cosyns,Christi Deaton,Ian D. Graham,Michael Stephen Hall,FD Richard Hobbs,Maja Lisa Løchen,Herbert Löllgen,Pedro Marques-Vidal,Joep Perk,Eva Prescott,Josep Redon,Dimitrios J. Richter,Naveed Sattar,Y.M. Smulders,Monica Tiberi,H. Bart van der Worp,Ineke van Dis,W M Monique Verschuren +25 more
TL;DR: In this paper, a randomized clinical trial was conducted to evaluate the effect of preterax and Diamicron Modified Release Controlled Evaluation (MDE) on the risk of stroke.
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