2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk
Alison Halliday,Colin Baigent,François Mach,Borislava Mihaylova,Borislava Mihaylova,Brian A. Ference +5 more
TLDR
Authors/Task Force Members (François Macha, Colin Baigentb,∗∗,2, Alberico L. Catapanoc), ESC Committee for Practice Guidelines (CPG) (Stephan Windeckeraa), ESC National Cardiac Societies (Djamaleddine Nibouchean, Parounak H. Patelcl)About:
This article is published in Atherosclerosis.The article was published on 2019-09-02 and is currently open access. It has received 2972 citations till now. The article focuses on the topics: Lipid modification & Very low-density lipoprotein.read more
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Efficacy and Safety of Alirocumab in Children and Adolescents With Homozygous Familial Hypercholesterolemia: Phase 3, Multinational Open-Label Study
TL;DR: In this paper , the efficacy and safety of the PCSK9 inhibitor, alirocumab, in pediatric patients (aged 8-17 years) with inadequately controlled homozygous familial hypercholesterolemia was examined.
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Statin treatment reduces the risk of death among elderly frail patients: evidence from a large population-based cohort.
TL;DR: In a real-life setting, adherence to statin treatment reduced the death risk also in frail elderly patients, however, in these patients, the benefit ofstatin treatment may be lower than in those in good clinical conditions.
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The effects of cardiac drugs on human erythrocyte carbonic anhydrase I and II isozymes
TL;DR: The tested cardiac drugs showed potent in vitro inhibition of the hCA I and II isozymes, and in patients with atherosclerotic heart disease, these drugs may be preferred primarily due to the beneficial effects of carbonic anhydrase inhibition on atherosclerosis.
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Very-low-calorie ketogenic diet for the management of obesity, overweight and related disorders.
TL;DR: The present narrative review discusses available evidence and provides practical recommendations for the management of VLCKD and improvements in hypertension, type 2 diabetes and dyslipidemia follows.
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Generalizability of the REDUCE-IT trial and cardiovascular outcomes associated with hypertriglyceridemia among patients potentially eligible for icosapent ethyl therapy: An analysis of the REduction of Atherothrombosis for Continued Health (REACH) registry
Fabien Picard,Deepak L. Bhatt,Gregory Ducrocq,Gregory Ducrocq,E. Magnus Ohman,Shinya Goto,Kim A. Eagle,Peter W.F. Wilson,Sidney C. Smith,Yedid Elbez,Philippe Gabriel Steg +10 more
TL;DR: The REDUCE-IT trial as mentioned in this paper showed that high-dose icosapent-ethyl reduced the risk of ischemic events in statin-treated patients with elevated triglycerides (TG) and either atherosclerotic cardiovascular disease (ASCVD) or diabetes plus at least one risk factor.
References
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TL;DR: In this paper, a randomized clinical trial was conducted to evaluate the effect of preterax and Diamicron Modified Release Controlled Evaluation (MDE) on the risk of stroke.
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