2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk
Alison Halliday,Colin Baigent,François Mach,Borislava Mihaylova,Borislava Mihaylova,Brian A. Ference +5 more
TLDR
Authors/Task Force Members (François Macha, Colin Baigentb,∗∗,2, Alberico L. Catapanoc), ESC Committee for Practice Guidelines (CPG) (Stephan Windeckeraa), ESC National Cardiac Societies (Djamaleddine Nibouchean, Parounak H. Patelcl)About:
This article is published in Atherosclerosis.The article was published on 2019-09-02 and is currently open access. It has received 2972 citations till now. The article focuses on the topics: Lipid modification & Very low-density lipoprotein.read more
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Circulating Lipoprotein Lipids, Apolipoproteins and Ischemic Stroke.
TL;DR: A Mendelian randomization study is conducted to disentangle the comparative effects of lipids and apolipoproteins on ischemic stroke.
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Novel emerging therapies in atherosclerosis targeting lipid metabolism
Manasvi Gupta,Colin Blumenthal,Subhankar Chatterjee,Dhrubajyoti Bandyopadhyay,Vardhmaan Jain,Carl J. Lavie,Salim S. Virani,Kausik K. Ray,Wilbert S. Aronow,Raktim K. Ghosh +9 more
TL;DR: New options now exist for the prevention of atherosclerosis in patients that are not optimized on statin therapy and newly approved non-statin-based therapies such as ezetimibe, icosapent ethyl (IPE), and bempedoic acid are discussed.
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Prognostic value of coronary artery calcium score, area, and density among individuals on statin therapy vs. non-users: The coronary artery calcium consortium
Albert D. Osei,Mohammadhassan Mirbolouk,Daniel S. Berman,Matthew J. Budoff,Michael D. Miedema,Alan Rozanski,John A. Rumberger,Leslee J. Shaw,Mahmoud Al Rifai,Omar Dzaye,Garth Graham,Maciej Banach,Roger S. Blumenthal,Zeina Dardari,Khurram Nasir,Michael J. Blaha +15 more
TL;DR: CAC scoring retains robust risk prediction in statin users, and the changing relationship of CAC density with outcomes may explain the slightly weaker relationship ofCAC with outcomes instatin users.
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Naturally Occurring PCSK9 Inhibitors
TL;DR: The present review has summarized the current knowledge on natural compounds or extracts that have shown an inhibitory effect on PCSK9, either in experimental or clinical settings, and summarized the pharmacodynamic and pharmacokinetic profiles of the listed compounds.
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Machine Learning Improves Cardiovascular Risk Definition for Young, Asymptomatic Individuals
Fátima Sánchez-Cabo,Xavier Rossello,Valentin Fuster,Fernando Benito,Jose Pedro Manzano,Juan Carlos Silla,Juan Miguel Fernández-Alvira,Belén Oliva,Leticia Fernández-Friera,Beatriz López-Melgar,José M. Mendiguren,Javier Sanz,Jose M. Ordovas,Vicente Andrés,Antonio Fernández-Ortiz,Héctor Bueno,Borja Ibanez,José Manuel García-Ruiz,Enrique Lara-Pezzi +18 more
TL;DR: The EN-PESA model uses age, systolic blood pressure, and 10 commonly used blood/urine tests and dietary intake values to identify young, asymptomatic individuals with an increased risk of CVD based on their extension and progression of SA.
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TL;DR: In this paper, a randomized clinical trial was conducted to evaluate the effect of preterax and Diamicron Modified Release Controlled Evaluation (MDE) on the risk of stroke.
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