2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk
Alison Halliday,Colin Baigent,François Mach,Borislava Mihaylova,Borislava Mihaylova,Brian A. Ference +5 more
TLDR
Authors/Task Force Members (François Macha, Colin Baigentb,∗∗,2, Alberico L. Catapanoc), ESC Committee for Practice Guidelines (CPG) (Stephan Windeckeraa), ESC National Cardiac Societies (Djamaleddine Nibouchean, Parounak H. Patelcl)About:
This article is published in Atherosclerosis.The article was published on 2019-09-02 and is currently open access. It has received 2972 citations till now. The article focuses on the topics: Lipid modification & Very low-density lipoprotein.read more
Citations
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Journal ArticleDOI
Lipid lowering therapy in cardiovascular disease: From myth to molecular reality
Philipp Mourikis,Saif Zako,Lisa Dannenberg,Amir M. Nia,Yvonne Heinen,Lucas Busch,Hannah Richter,Thomas Hohlfeld,Tobias Zeus,Malte Kelm,Amin Polzin +10 more
TL;DR: Current and future options for lipid management are presented depending on different drug classes, and using antisense-oligonucleotides against ApoC-III and Lp(a) resulted in promising outcomes.
Journal ArticleDOI
New cardiovascular prevention guidelines: How to optimally manage dyslipidaemia and cardiovascular risk in 2021 in patients needing secondary prevention?
Dan Atar,J. Wouter Jukema,Bart Molemans,Pam R. Taub,Shinya Goto,François Mach,Cesar CerezoOlmos,James A. Underberg,Anthony C Keech,Lale Tokgozoglu,Marc P. Bonaca +10 more
TL;DR: A review of established and emerging agents that reduce LDL-C is provided in this paper, where the authors provide a case study to illustrate application of current lipid-lowering guidelines in various clinical settings.
Journal ArticleDOI
Benefit of Targeting a LDL (Low-Density Lipoprotein) Cholesterol <70 mg/dL During 5 Years After Ischemic Stroke.
Pierre Amarenco,Jong S. Kim,Julien Labreuche,Hugo Charles,Maurice Giroud,Byung-Chul Lee,Marie-Hélène Mahagne,Norbert Nighoghossian,Philippe Gabriel Steg,Éric Vicaut,Éric Vicaut,Eric Bruckert,Treat Stroke to Target Investigators +12 more
TL;DR: After an ischemic stroke of documented atherosclerotic origin, targeting a LDL cholesterol of <70 mg/dL during 5.3 years avoided 1 subsequent major vascular event in 4 (number needed to treat of 30) and no increase in intracranial hemorrhage.
Journal ArticleDOI
Indirect comparison of the efficacy and safety of alirocumab and evolocumab: a systematic review and network meta-analysis.
Paul Guedeney,Paul Guedeney,Sabato Sorrentino,Sabato Sorrentino,Gennaro Giustino,Céline Chapelle,Silvy Laporte,Bimmer E. Claessen,Edouard Ollier,Anton Camaj,Deborah N. Kalkman,Deborah N. Kalkman,Birgit Vogel,Salvatore De Rosa,Ciro Indolfi,Benoit Lattuca,Michel Zeitouni,Mathieu Kerneis,Johanne Silvain,Jean-Philippe Collet,Roxana Mehran,Gilles Montalescot +21 more
TL;DR: Alirocumab and evolocumab share a similar safety profile except for injection site reaction and no significant differences were observed across the efficacy endpoints, except for all-cause death, which may be related to the heterogeneity of the studied populations treated with the two drugs.
Journal ArticleDOI
Low lipoprotein(a) levels and risk of disease in a large, contemporary, general population study
TL;DR: In this paper, the authors found no concordant association of low levels of lipoprotein(a) plasma levels and corresponding LPA genotypes with the risk of any cancer (i.e. cancer subtypes combined) or infectious disease was seen.
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