2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk
Alison Halliday,Colin Baigent,François Mach,Borislava Mihaylova,Borislava Mihaylova,Brian A. Ference +5 more
TLDR
Authors/Task Force Members (François Macha, Colin Baigentb,∗∗,2, Alberico L. Catapanoc), ESC Committee for Practice Guidelines (CPG) (Stephan Windeckeraa), ESC National Cardiac Societies (Djamaleddine Nibouchean, Parounak H. Patelcl)About:
This article is published in Atherosclerosis.The article was published on 2019-09-02 and is currently open access. It has received 2972 citations till now. The article focuses on the topics: Lipid modification & Very low-density lipoprotein.read more
Citations
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Journal ArticleDOI
Cardiac Computed Tomography for Personalized Management of Patients With Type 2 Diabetes Mellitus.
Rhanderson Cardoso,Rhanderson Cardoso,Ramzi Dudum,Ramzi Dudum,Richard A. Ferraro,Márcio Sommer Bittencourt,Ron Blankstein,Michael J. Blaha,Khurram Nasir,Sanjay Rajagopalan,Erin D. Michos,Roger S. Blumenthal,Miguel Cainzos-Achirica,Miguel Cainzos-Achirica +13 more
TL;DR: The use of the coronary artery calcium score as a decision aid in individuals with type 2 diabetes mellitus without clinical atherosclerotic cardiovascular disease to guide the use of preventive pharmacotherapies, such as aspirin, lipid-lowering mediations, and cardiometabolic agents is reviewed.
Journal ArticleDOI
Implications for REDUCE IT in clinical practice
TL;DR: Addition of icosapent ethyl to statins has recently been shown to markedly lower risk of cardiovascular disease events in patients with established atherosclerotic CVD and high risk patients with type II diabetes mellitus, and this data is discussed in the context of current guidelines and synthesized in a decision pathway to guide combination lipid-lowering therapy in patients at high ASCVD risk.
Journal ArticleDOI
The Impact of the 2019 European Guideline for Cardiovascular Risk Management: A Cross-Sectional Study in General Practice.
TL;DR: There is still a large undeveloped potential to lower CV risk by introducing conventional lipid-lowering drugs, particularly in patients at high or very high CV risk, as indicated by the 2019 ESC/EAS guideline.
Journal ArticleDOI
Inclisiran-Silencing the Cholesterol, Speaking up the Prognosis.
Sylwester Rogula,Ewelina Błażejowska,Aleksandra Gąsecka,Łukasz Szarpak,Miłosz Jaguszewski,Tomasz Mazurek,Krzysztof J. Filipiak +6 more
TL;DR: Inclisiran as mentioned in this paper is a disruptive, first-in-class small interfering RNA (siRNA)-based therapeutic developed for the treatment of hypercholesterolemia that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) synthesis, thereby upregulating the number of LDL receptors on the hepatocytes, thus lowering the plasma LDL-C concentration.
Book ChapterDOI
LDL-Cholesterol-Lowering Therapy.
TL;DR: The causal relation between elevated levels of LDL-C and cardiovascular disease has been largely established by experimental and clinical studies and the need to develop additional lipid-lowering drugs to be used in combination with or in alternative to statins in patients intolerant to the treatment is raised.
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TL;DR: In this paper, a randomized clinical trial was conducted to evaluate the effect of preterax and Diamicron Modified Release Controlled Evaluation (MDE) on the risk of stroke.
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