2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk
Alison Halliday,Colin Baigent,François Mach,Borislava Mihaylova,Borislava Mihaylova,Brian A. Ference +5 more
TLDR
Authors/Task Force Members (François Macha, Colin Baigentb,∗∗,2, Alberico L. Catapanoc), ESC Committee for Practice Guidelines (CPG) (Stephan Windeckeraa), ESC National Cardiac Societies (Djamaleddine Nibouchean, Parounak H. Patelcl)About:
This article is published in Atherosclerosis.The article was published on 2019-09-02 and is currently open access. It has received 2972 citations till now. The article focuses on the topics: Lipid modification & Very low-density lipoprotein.read more
Citations
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Application of non-HDL cholesterol for population-based cardiovascular risk stratification: results from the Multinational Cardiovascular Risk Consortium
Fabian J. Brunner,Christoph Waldeyer,Francisco Ojeda,Veikko Salomaa,Frank Kee,Susana Sans,Barbara Thorand,Simona Giampaoli,Paolo Brambilla,Hugh Tunstall-Pedoe,Marie Moitry,Licia Iacoviello,Giovanni Veronesi,Guido Grassi,Ellisiv B. Mathiesen,Stefan Söderberg,Allan Linneberg,Hermann Brenner,Philippe Amouyel,Jean Ferrières,Abdonas Tamosiunas,Yuriy P. Nikitin,Wojciech Drygas,Olle Melander,Karl-Heinz Joeckel,David M. Leistner,Jonathan E. Shaw,Demosthenes B. Panagiotakos,Leon A. Simons,Maryam Kavousi,Ramachandran S. Vasan,Robin P. F. Dullaart,S. Goya Wannamethee,Ulf Risérus,Steven Shea,James A. de Lemos,Torbjørn Omland,Kari Kuulasmaa,Ulf Landmesser,Stefan Blankenberg,Tanja Zeller,K.J. Lackner,Philipp S. Wild,Annette Peters,Christine Meisinger,Henry Voelzke,Marcus Doerr,Matthias Nauck,Ben Schoettker,Thiess Lorenz,Nataliya Makarova,Börge Schmidt,Jens Klotsche,Wolfgang Koenig,Jukka Kontto,Satu Männistö,T. Jaaskelainen,Teemu J. Niiranen,P. Jousilahti,A. Metspalu,Maris Alver,C. Donfrancesco,Stefano Signorini,Francesco Gianfagna,S. Costanzo,Mark Woodward,Annette J. Dobson,G.G. Giles,Allison M. Hodge,Dianna J. Magliano,Tom Wilsgaard,Magnus Lyngbakken,Kristian Hveem,Mats Eliasson,Gunnar Engström,Martin Ingelsson,Torben Jørgensen,Raphael Twerenbold,Jean Dallongeville,S. K. Malyutina,Andrzej Pajak,Martin Bobak,Peter H. Whincup,Christos Pitsavos,E J Benjamin,Stephan J. L. Bakker,Mohammad Kamran Ikram +86 more
TL;DR: Non-HDL cholesterol concentrations in blood are strongly associated with long-term risk of atherosclerotic cardiovascular disease and this tool provides a simple tool for individual long- term risk assessment and the potential benefit of early lipid-lowering intervention.
Journal ArticleDOI
Beyond cholesterol metabolism: The pleiotropic effects of proprotein convertase subtilisin/kexin type 9 (PCSK9). Genetics, mutations, expression, and perspective for long-term inhibition.
Arturo Cesaro,Vanessa Bianconi,Felice Gragnano,Elisabetta Moscarella,Fabio Fimiani,Emanuele Monda,Olga Scudiero,Giuseppe Limongelli,Matteo Pirro,Paolo Calabrò +9 more
TL;DR: This review provides a comprehensive overview of the genetics, biochemical structure, expression, and function of PCSK9 and discusses the potential implications of its long‐term pharmacological inhibition.
Journal ArticleDOI
Meta-Analysis of Inclisiran for the Treatment of Hypercholesterolemia.
TL;DR: In patients with hypercholesterolemia, inclisiran decreased LDL level by 51% without significant adverse effects, and was associated with a lower major adverse cardiovascular event rate.
Journal ArticleDOI
Impact of prior statin use on clinical outcomes in COVID-19 patients: data from tertiary referral hospitals during COVID-19 pandemic in Italy.
Gianfranco Mitacchione,Marco Schiavone,Antonio Curnis,Marcello Arca,Spinello Antinori,Alessio Gasperetti,Giosuè Mascioli,Paolo Severino,Federica Sabato,Maria M. Caracciolo,Gianmarco Arabia,Laura D'Erasmo,Maurizio Viecca,Massimo Mancone,Massimo Galli,Giovanni B. Forleo +15 more
TL;DR: In this paper, the impact of prior statin use on the severity and mortality of COVID-19 patients was assessed using the National Early Warning Score (NEWS) and secondary outcomes, respectively.
Journal ArticleDOI
Low-density lipoprotein cholesterol lowering treatment: the current approach.
Irina Crismaru,Anca Pantea Stoian,Ovidiu Gabriel Bratu,Mihnea-Alexandru Găman,Ana Maria Alexandra Stănescu,Nicolae Bacalbasa,Camelia Cristina Diaconu +6 more
TL;DR: The present narrative review discusses the latest guidelines of the European Atherosclerosis Society/European Society of Cardiology for the management of dyslipidemia, focusing on LDLc-lowering drugs that are either already available on the market or under development.
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Atherosclerosis is an Inflammatory Disease
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TL;DR: Despite changes in lifestyle and the use of new pharmacologic approaches to lower plasma cholesterol concentrations, cardiovascular disease continues to be the principal cause of death in the United States, Europe, and much of Asia.
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Massimo Piepoli,Arno W. Hoes,Stefan Agewall,Christian Albus,Carlos Brotons,Alberico L. Catapano,Marie Therese Cooney,Ugo Corrà,Bernard Cosyns,Christi Deaton,Ian D. Graham,Michael Stephen Hall,FD Richard Hobbs,Maja Lisa Løchen,Herbert Löllgen,Pedro Marques-Vidal,Joep Perk,Eva Prescott,Josep Redon,Dimitrios J. Richter,Naveed Sattar,Y.M. Smulders,Monica Tiberi,H. Bart van der Worp,Ineke van Dis,W M Monique Verschuren +25 more
TL;DR: In this paper, a randomized clinical trial was conducted to evaluate the effect of preterax and Diamicron Modified Release Controlled Evaluation (MDE) on the risk of stroke.
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