2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk
Alison Halliday,Colin Baigent,François Mach,Borislava Mihaylova,Borislava Mihaylova,Brian A. Ference +5 more
TLDR
Authors/Task Force Members (François Macha, Colin Baigentb,∗∗,2, Alberico L. Catapanoc), ESC Committee for Practice Guidelines (CPG) (Stephan Windeckeraa), ESC National Cardiac Societies (Djamaleddine Nibouchean, Parounak H. Patelcl)About:
This article is published in Atherosclerosis.The article was published on 2019-09-02 and is currently open access. It has received 2972 citations till now. The article focuses on the topics: Lipid modification & Very low-density lipoprotein.read more
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Impact of Different Doses of Omega-3 Fatty Acids on Cardiovascular Outcomes: a Pairwise and Network Meta-analysis.
Marco Lombardi,Marco Lombardi,Juan Guido Chiabrando,Juan Guido Chiabrando,Giovanni Maria Vescovo,Edoardo Bressi,Marco Giuseppe Del Buono,Marco Giuseppe Del Buono,Salvatore Carbone,Rachel A. Koenig,Benjamin W. Van Tassell,Antonio Abbate,Giuseppe Biondi-Zoccai,Dave L. Dixon +13 more
TL;DR: Omega-3 fatty acid (O3FA) supplementation has shown conflicting evidence regarding its benefit in cardiovascular events, so a pairwise and network meta-analysis to elucidate the benefit of different doses of O3FA supplementation in cardiovascular prevention was performed.
Journal ArticleDOI
Treatment of dyslipidemia in kidney transplantation
TL;DR: Rather than using high-dose statin in difficult patients, an association with ezetimibe is suggested, and new lipid-lowering drugs are emerging but their safety and efficacy in KT patients still need to be assessed.
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The need for clinical judgement in the application of evidence-based medicine.
TL;DR: In this paper, the authors assess ways in which the unthinking application of EBM can go wrong; these include withholding therapy in patients whose subgroup was excluded from clinical trials, blind acceptance of the numbers, reliance on studies with crucial design flaws and reliance on intention-to-treat analysis when it is not appropriate.
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PCSK9 inhibition in clinical practice: treatment patterns and attainment of lipid goals in a large health maintenance organization
TL;DR: In real-world practice of patients treated by PCSK9i, high proportion of early treatment discontinuation was evident, with non-negligible re-initiation rates but overall low medication coverage over time, which have contributed to sub-optimal attainment of LDL-C treatment goals, particularly observed in patients with severe hypercholesterolemia, inadequate drug adherence, and those using PCSK 9i as monotherapy.
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Nutrition and physical activity recommendations from the United States and European cardiovascular guidelines: a comparative review.
TL;DR: In 2018 and 2019, the American Heart Association (AHA) and American College of Cardiology (ACC) published new guidelines for lipid management and primary prevention of cardiovascular disease (CVD), respectively.
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TL;DR: In this paper, a randomized clinical trial was conducted to evaluate the effect of preterax and Diamicron Modified Release Controlled Evaluation (MDE) on the risk of stroke.
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