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A comprehensive review of SHP2 and its role in cancer
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This article is published in Cellular oncology.The article was published on 2022-09-06. It has received 17 citations till now. The article focuses on the topics: Medicine & Biology.read more
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SH2 Domains: Folding, Binding and Therapeutical Approaches
Awa Diop,Daniele Santorelli,Francesca Malagrinò,Caterina Nardella,Valeria Pennacchietti,Livia Pagano,Lucia Marcocci,Paola Pietrangeli,Stefano Gianni,Angelo Toto +9 more
TL;DR: In this paper , the structural, folding stability, and binding properties of SH2 domains and their roles in molecular pathways and pathogenesis are summarized and different strategies employed to modulate/inhibit SH2 domain binding.
Journal ArticleDOI
Allostery Frustrates the Experimentalist
Per Jemth,Sameer Varma +1 more
TL;DR: The concept of allostery was broadened to encompass all types of long-range interactions across a protein including purely entropic changes without a conformational change in single protein domains as mentioned in this paper .
Journal ArticleDOI
Modeling (not so) rare developmental disorders associated with mutations in the protein-tyrosine phosphatase SHP2
TL;DR: The role of protein tyrosine phosphatase (PTPN11) variants in rare diseases and advances in the understanding of its pathogenesis using model systems are discussed in this article .
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Experiment-guided molecular simulations define a heterogeneous structural ensemble for the PTPN11 tandem SH2 domains
Michelangelo Marasco,John P. Kirkpatrick,Teresa Carlomagno,Jochen S. Hub,Massimiliano Anselmi +4 more
TL;DR: In this paper , the structural ensemble of the tandem SH2 in solution was determined using experiment-guided molecular simulations, in agreement with experimental data from small-angle X-ray scattering and NMR residual dipolar couplings.
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Traditional Chinese medicine inhibits PD-1/PD-L1 axis to sensitize cancer immunotherapy: a literature review
Adelina Debisow,GoBosy Alice +1 more
TL;DR: Wang et al. as mentioned in this paper examined the PD-1/PD-L1 axis and its role in tumor immune escape while exploring how TCM therapies can modulate the PD 1/PD L 1 axis to improve the efficacy of cancer immunotherapy.
References
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Cell signaling by receptor-tyrosine kinases
TL;DR: Understanding of the complex signaling networks downstream from RTKs and how alterations in these networks are translated into cellular responses provides an important context for therapeutically countering the effects of pathogenic RTK mutations in cancer and other diseases.
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Comprehensive genomic characterization defines human glioblastoma genes and core pathways
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TL;DR: The interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated gliobeasts, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer.
Journal ArticleDOI
Microenvironmental regulation of tumor progression and metastasis.
TL;DR: The paradoxical roles of the tumor microenvironment during specific stages of cancer progression and metastasis are discussed, as well as recent therapeutic attempts to re-educate stromal cells within the TME to have anti-tumorigenic effects.
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PD-1 and its ligands in tolerance and immunity
TL;DR: Current understanding of the immunoregulatory functions of PD-1 and its ligands and their therapeutic potential are discussed and an inhibitory bidirectional interaction between PD-L1 and B7-1 is discovered, revealing new ways the B7:CD28 family regulates T cell activation and tolerance.
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The Nuclear Factor NF-κB Pathway in Inflammation
TL;DR: How genetic evidence in mice has revealed complex roles for the NF-kappaB in inflammation that suggest both pro- and anti-inflammatory roles for this pathway is described.