Journal ArticleDOI
A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies.
TLDR
This review focuses on chemometric techniques and pharmaceutical NIRS applications, covering qualitative analyses, quantitative methods and on-line applications for near-infrared spectroscopy for pharmaceutical forms.About:
This article is published in Journal of Pharmaceutical and Biomedical Analysis.The article was published on 2007-07-27. It has received 1041 citations till now.read more
Citations
More filters
Dissertation
Desenvolvimento de uma metodologia baseada na espectroscopia no infravermelho próximo para determinação do produto de degradação do captopril em comprimidos
TL;DR: In this paper, the authors proposed a new methodology for the determination of this degradation product, spectroscopy based on near infrared and chemometric methods, which can be easily used for routine analysis and does not use chemical agents harmful to the environment.
Journal ArticleDOI
Novel applications of infrared technologies in dairy industry
TL;DR: In this article, the authors developed and implemented NIRS prediction models for at-line and inexpensive quantification of minerals and fatty acids of commercial cheeses in order to quickly incorporate this information on the label of dairy products.
Journal ArticleDOI
Discrimination of Substandard and Falsified Formulations from Genuine Pharmaceuticals Using NIR Spectra and Machine Learning.
Olatunde Awotunde,Nicholas Roseboom,Jin Cai,Kathleen L. Hayes,Revati Rajane,Ruoyan Chen,Abdullah Yusuf,Marya Lieberman +7 more
TL;DR: In this article , a simple library of lab-formulated binary mixtures of an active pharmaceutical ingredient (API) with two diluents gave good performance on field screening tasks, such as discriminating substandard and falsified formulations of the API.
Journal ArticleDOI
Non-invasive detection technologies of solid foreign matter and their applications to lyophilized pharmaceutical products: A review.
Ines Esma Achouri,Alan Rhoden,Sophie Hudon,Ryan Gosselin,Jean-Sébastien Simard,Nicolas Abatzoglou +5 more
TL;DR: This review is motivated by the need for new control strategies for foreign matter (FM) detection in lyophilized products; more specifically, it assesses the reliability of non-destructive technologies for FM detection in dried samples.
Journal ArticleDOI
A NIR, 1H-NMR, LC-MS and chemometrics pilot study on the origin of carvedilol drug substances: a tool for discovering falsified active pharmaceutical ingredients.
Maria Luisa Raimondo,Anna Borioni,Francesca Prestinaci,Isabella Sestili,Maria Cristina Gaudiano +4 more
TL;DR: In this article, a pilot study explores the profile of carvedilol active ingredients and possible differences related to the origin using three different techniques: principal component analysis (PCA), cluster analysis and PLSDA discriminant analysis.
References
More filters
Book
Neural Networks: A Comprehensive Foundation
TL;DR: Thorough, well-organized, and completely up to date, this book examines all the important aspects of this emerging technology, including the learning process, back-propagation learning, radial-basis function networks, self-organizing systems, modular networks, temporal processing and neurodynamics, and VLSI implementation of neural networks.
Journal ArticleDOI
Classification and Regression Trees.
Book
Classification and regression trees
TL;DR: The methodology used to construct tree structured rules is the focus of a monograph as mentioned in this paper, covering the use of trees as a data analysis method, and in a more mathematical framework, proving some of their fundamental properties.
Journal ArticleDOI
Nearest neighbor pattern classification
Thomas M. Cover,Peter E. Hart +1 more
TL;DR: The nearest neighbor decision rule assigns to an unclassified sample point the classification of the nearest of a set of previously classified points, so it may be said that half the classification information in an infinite sample set is contained in the nearest neighbor.