Journal ArticleDOI
A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies.
TLDR
This review focuses on chemometric techniques and pharmaceutical NIRS applications, covering qualitative analyses, quantitative methods and on-line applications for near-infrared spectroscopy for pharmaceutical forms.About:
This article is published in Journal of Pharmaceutical and Biomedical Analysis.The article was published on 2007-07-27. It has received 1041 citations till now.read more
Citations
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Journal ArticleDOI
Spectroscopic-Based Chemometric Models for Quantifying Low Levels of Solid-State Transitions in Extended Release Theophylline Formulations.
TL;DR: The developed Raman and NIR chemometric models developed had good accuracy and precision as demonstrated by closeness of the predicted values for the independent observations to the actual TMO content hence the developed models can serve as useful tools in quantifying and controlling solid state transitions in extended release theophylline products.
Journal ArticleDOI
Role of excipients on solid-state properties of piroxicam during processing.
TL;DR: It is demonstrated that the physical stability of hydrate-anhydrate systems in process environments is complicated by a multitude of factors on both macroscopic level and molecular level, and that variable selection for PLS regression is a valuable tool for screening the effects of excipients on the solid-state properties of pharmaceuticals.
Journal ArticleDOI
Multivariate method for prediction of fumonisins B1 and B2 and zearalenone in Brazilian maize using Near Infrared Spectroscopy (NIR)
Denize Tyska,Adriano Olnei Mallmann,Juliano Kobs Vidal,Carlos A. A. de Almeida,Luciane Tourem Gressler,Carlos Augusto Mallmann +5 more
TL;DR: This is the first study providing scientific knowledge on the determination of FBs and ZEN in Brazilian maize samples using NIR, which is confirmed as a reliable alternative methodology for the analysis of such toxins.
Journal ArticleDOI
Two-dimensional heterospectral correlation analysis of water and liquid oleic acid using an online near-infrared/mid-infrared dual-region spectrometer.
TL;DR: 2D NIR/mid-IR heterospectral correlation analysis is useful not only for NIR band assignments, but also for molecular structure studies, and the spectrometer developed makes this analysis even more accessible.
Journal ArticleDOI
Applications of Quantum Cascade Laser Spectroscopy in the Analysis of Pharmaceutical Formulations.
Nataly J. Galán-Freyle,Leonardo C. Pacheco-Londoño,Andrés D. Román-Ospino,Samuel P. Hernández-Rivera +3 more
TL;DR: The relatively high power of the quantum-cascade-laser-based spectroscopic system resulted in the design of detection and quantification methodologies for pharmaceutical applications with high accuracy and precision that are comparable to those of methodologies based on near-infrared spectroscopy, attenuated total reflection mid-inf infrared Fourier transform infrared spectroscopes, and Raman spectroscope.
References
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Book
Neural Networks: A Comprehensive Foundation
TL;DR: Thorough, well-organized, and completely up to date, this book examines all the important aspects of this emerging technology, including the learning process, back-propagation learning, radial-basis function networks, self-organizing systems, modular networks, temporal processing and neurodynamics, and VLSI implementation of neural networks.
Journal ArticleDOI
Classification and Regression Trees.
Book
Classification and regression trees
TL;DR: The methodology used to construct tree structured rules is the focus of a monograph as mentioned in this paper, covering the use of trees as a data analysis method, and in a more mathematical framework, proving some of their fundamental properties.
Journal ArticleDOI
Nearest neighbor pattern classification
Thomas M. Cover,Peter E. Hart +1 more
TL;DR: The nearest neighbor decision rule assigns to an unclassified sample point the classification of the nearest of a set of previously classified points, so it may be said that half the classification information in an infinite sample set is contained in the nearest neighbor.