Journal ArticleDOI
A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies.
TLDR
This review focuses on chemometric techniques and pharmaceutical NIRS applications, covering qualitative analyses, quantitative methods and on-line applications for near-infrared spectroscopy for pharmaceutical forms.About:
This article is published in Journal of Pharmaceutical and Biomedical Analysis.The article was published on 2007-07-27. It has received 1041 citations till now.read more
Citations
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Journal ArticleDOI
Review of real-time release testing of pharmaceutical tablets: State-of-the art, challenges and future perspective.
Daniel Markl,Daniel Markl,Martin Warman,Melanie Dumarey,Eva-Lotta Bergman,Staffan Folestad,Zhenqi Shi,Leo Francis Manley,Daniel J. Goodwin,J. Axel Zeitler +9 more
TL;DR: A systematic development workflow for the robust design of an RTRT environment is presented and the discussion of key considerations for the identification of the critical quality attributes and points of testing are discussed.
Journal ArticleDOI
Prospects for multivariate classification of a pharmaceutical intermediate with near-infrared spectroscopy as a process analytical technology (PAT) production control supplement
TL;DR: NIR spectroscopy was applied to develop a fast and reliable quality control system for a pharmaceutical substance to support information obtained through PAT surveillance of its manufacturing process to derive a reasonable limit for the reduced chemometric summary quality measure (Hotteling's T(2).
Journal ArticleDOI
Quantitative monitoring of yeast fermentation using Raman spectroscopy.
Jens Asmus Iversen,Jens Asmus Iversen,Rolf W. Berg,Birgitte Kiær Ahring,Birgitte Kiær Ahring +4 more
TL;DR: A method was developed to correct the Raman signal for the attenuation caused by light scattering cell particulate, hence enabling quantification of reaction components and possibly measurement of yeast cell concentrations in a Saccharomyces cerevisiae fermentation process using a Raman spectroscopy instrument equipped with a robust sapphire ball probe.
This item is the archived peer-reviewed author-version of: Development of a fluid bed granulation process control strategy based on real-time process and product measurements
Anneleen Burggraeve,T. Van,Den Kerkhof,Mario Hellings,Chris Vervaet,Y. Vander Heyden,T. De Beer +6 more
TL;DR: A feed-forward process control method was developed, where in-line collected granulation information during the process spraying phase was used to determine the optimum drying temperature of the consecutive drying phase, which led to the desired batch bulk density at the end of the granulation process.
Journal ArticleDOI
Recent trends in quality control, discrimination and authentication of alcoholic beverages using nondestructive instrumental techniques
Muhammad Arslan,Haroon Elrasheid Tahir,Muhammad Zareef,Jiyong Shi,Allah Rakha,Muhammad Bilal,Huang Xiaowei,Li Zhihua,Zou Xiaobo +8 more
TL;DR: This review aims to highlight the most relevant and current information on the use of nondestructive instrumental techniques for evaluating quality, discrimination and authentication of alcoholic beverages and will serve as a guidance document for large scale production units for implementation of these laboratory-based smart techniques.
References
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Book
Neural Networks: A Comprehensive Foundation
TL;DR: Thorough, well-organized, and completely up to date, this book examines all the important aspects of this emerging technology, including the learning process, back-propagation learning, radial-basis function networks, self-organizing systems, modular networks, temporal processing and neurodynamics, and VLSI implementation of neural networks.
Journal ArticleDOI
Classification and Regression Trees.
Book
Classification and regression trees
TL;DR: The methodology used to construct tree structured rules is the focus of a monograph as mentioned in this paper, covering the use of trees as a data analysis method, and in a more mathematical framework, proving some of their fundamental properties.
Journal ArticleDOI
Nearest neighbor pattern classification
Thomas M. Cover,Peter E. Hart +1 more
TL;DR: The nearest neighbor decision rule assigns to an unclassified sample point the classification of the nearest of a set of previously classified points, so it may be said that half the classification information in an infinite sample set is contained in the nearest neighbor.