Journal ArticleDOI
A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies.
TLDR
This review focuses on chemometric techniques and pharmaceutical NIRS applications, covering qualitative analyses, quantitative methods and on-line applications for near-infrared spectroscopy for pharmaceutical forms.About:
This article is published in Journal of Pharmaceutical and Biomedical Analysis.The article was published on 2007-07-27. It has received 1041 citations till now.read more
Citations
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Journal ArticleDOI
Differentiating Puerariae Lobatae Radix and Puerariae Thomsonii Radix using HPTLC coupled with multivariate classification analyses
TL;DR: High performance thin-layer chromatography combined with multivariate analysis is a promising technique for the quality control and differentiation of PLR and PTR.
Journal ArticleDOI
Monitoring and Control of a Continuous Grignard Reaction for the Synthesis of an Active Pharmaceutical Ingredient Intermediate Using Inline NIR spectroscopy
Albert Emili Cervera Padrell,Jesper Pram Nielsen,Michael Jønch Pedersen,Kim Müller Christensen,Asmus R. Mortensen,Tommy Skovby,Kim Dam-Johansen,Søren Kiil,Krist V. Gernaey +8 more
TL;DR: In this paper, a feed-forward feedback control loop is proposed to maintain the reaction as closely as possible to the stoichiometric ratio, leading the path to full process automation.
Journal ArticleDOI
Standard-free calibration transfer - An evaluation of different techniques☆
TL;DR: This contribution introduces, discusses and evaluates a wide-ranging subset of transfer approaches available in chemometrics and the field of machine learning, where they focus on techniques applicable in situations where transfer standards cannot be provided and only few reference measurements are available for the new setting.
Journal ArticleDOI
A new PAT/QbD approach for the determination of blend homogeneity: Combination of on-line NIRS analysis with PC Scores Distance Analysis (PC-SDA)
TL;DR: The new approach comprises calculation of Euclidean distances between PCA scores in a multidimensional space and determination of Moving Block Standard Deviations of successive Principal Component scores distances to estimate a time-window during blending where spectral variability decreases to a preset minimum.
Journal ArticleDOI
Rapid, noninvasive detection of Zika virus in Aedes aegypti mosquitoes by near-infrared spectroscopy.
Jill N. Fernandes,Lilha Maria Barbosa dos Santos,Thaís Chouin-Carneiro,Márcio G. Pavan,Gabriela de Azambuja Garcia,Mariana Rocha David,John C. Beier,Floyd E. Dowell,Rafael Maciel-de-Freitas,Maggy T. Sikulu-Lord +9 more
TL;DR: It is shown for the first time that NIRS is a rapid, reagent-free, and cost-effective tool that can be used to noninvasively detect ZIKV in heads and thoraces of intact Aedes aegypti mosquitoes with prediction accuracies of 94.2 to 99.3% relative to quantitative reverse transcription polymerase chain reaction (RT-qPCR).
References
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Book
Neural Networks: A Comprehensive Foundation
TL;DR: Thorough, well-organized, and completely up to date, this book examines all the important aspects of this emerging technology, including the learning process, back-propagation learning, radial-basis function networks, self-organizing systems, modular networks, temporal processing and neurodynamics, and VLSI implementation of neural networks.
Journal ArticleDOI
Classification and Regression Trees.
Book
Classification and regression trees
TL;DR: The methodology used to construct tree structured rules is the focus of a monograph as mentioned in this paper, covering the use of trees as a data analysis method, and in a more mathematical framework, proving some of their fundamental properties.
Journal ArticleDOI
Nearest neighbor pattern classification
Thomas M. Cover,Peter E. Hart +1 more
TL;DR: The nearest neighbor decision rule assigns to an unclassified sample point the classification of the nearest of a set of previously classified points, so it may be said that half the classification information in an infinite sample set is contained in the nearest neighbor.