Journal ArticleDOI
A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies.
TLDR
This review focuses on chemometric techniques and pharmaceutical NIRS applications, covering qualitative analyses, quantitative methods and on-line applications for near-infrared spectroscopy for pharmaceutical forms.About:
This article is published in Journal of Pharmaceutical and Biomedical Analysis.The article was published on 2007-07-27. It has received 1041 citations till now.read more
Citations
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Journal ArticleDOI
Variables selection methods in near-infrared spectroscopy.
TL;DR: This review focuses on the variable selection methods in NIR spectroscopy with some classical approaches and sophisticated methods such as successive projections algorithm (SPA), uninformative variable elimination (UVE) and elaborate search-based strategies.
Journal ArticleDOI
Qualitative and quantitative analysis of lignocellulosic biomass using infrared techniques: A mini-review
TL;DR: In this article, the progress and applications of infrared techniques in biomass study, and compares the infrared and the wet chemical methods for composition analysis, are summarized and compared, in addition to reviewing recent studies of biomass structure and composition.
Journal ArticleDOI
Multivariate data analysis in pharmaceutics: a tutorial review.
Tarja Rajalahti,Olav M. Kvalheim +1 more
TL;DR: An overview of latent variable methods used in pharmaceutics and integrated with advanced characterization techniques such as vibrational spectroscopy is provided.
Journal ArticleDOI
Antioxidants: Characterization, natural sources, extraction and analysis
Mircea Oroian,Isabel Escriche +1 more
TL;DR: In this paper the main classes of antioxidants are presented: vitamins, carotenoids and polyphenols.
References
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Journal ArticleDOI
Characterization and analysis of polymorphs by near-infrared spectrometry
TL;DR: In this paper, the authors developed a method for the characterization and determination of azithromycin polymorphs using near-infrared (NIR) spectrometry, where the drug is characterized by comparison with a NIR spectral library that permits one to determine whether the amount of crystalline form contained in an amorphous sample exceeds allowed levels.
Journal ArticleDOI
Moisture determination in hygroscopic drug substances by near infrared spectroscopy
TL;DR: The moisture level in a hygroscopic drug substance was successfully determined by near infrared spectroscopy using coulometric Karl Fischer titration as the reference method, stressing the importance of sample handling and proper application of the reference technique.
Journal ArticleDOI
The use of near-infrared spectroscopy in the efficient prediction of a specification for the residual moisture content of a freeze-dried product
TL;DR: A near-infrared spectroscopic (NIRS) method was developed for the measurement of the residual moisture content and, subsequently, the content of the active ingredient could be measured in the same sample vials after storage.
Journal ArticleDOI
At-line monitoring of a submerged filamentous bacterial cultivation using near-infrared spectroscopy.
S.Alison Arnolda,John Crowley,Seetharaman Vaidyanathan,Liliana Matheson,Pankaj Mohan,Jeffrey W. Hall,Linda M. Harvey,Brian McNeil +7 more
TL;DR: The emphasis in the present study is on providing an insight into the modelling process in such a complex matrix, which may be particularly important to the applicability of NIRS to such industrial bioprocesses.
Journal ArticleDOI
Transfer of NIR calibrations for pharmaceutical formulations between different instruments.
TL;DR: It was shown that it is possible to transfer calibrations between instruments of different configurations or even of different types, without loosing the prediction ability of the calibration.