Journal ArticleDOI
A review of near infrared spectroscopy and chemometrics in pharmaceutical technologies.
TLDR
This review focuses on chemometric techniques and pharmaceutical NIRS applications, covering qualitative analyses, quantitative methods and on-line applications for near-infrared spectroscopy for pharmaceutical forms.About:
This article is published in Journal of Pharmaceutical and Biomedical Analysis.The article was published on 2007-07-27. It has received 1041 citations till now.read more
Citations
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Journal ArticleDOI
Acetaminophen determination in low-dose pharmaceutical syrup by NIR spectroscopy
TL;DR: A robust near infrared (NIR) calibration model able to determine the acetaminophen content of a low-dose syrup formulation (2%, w/v) was developed and a good agreement was found between the NIR method and the theoretical concentrations.
Journal ArticleDOI
Determination of flow properties of pharmaceutical powders by near infrared spectroscopy.
Mafalda C. Sarraguça,Ana V. Cruz,Sandra Oliveira Soares,Helena Amaral,Paulo Costa,João A. Lopes +5 more
TL;DR: The potential of NIR spectroscopy in the determination of physical properties affecting the flowability of pharmaceutical powders is established.
Journal ArticleDOI
Non-destructive dose verification of two drugs within 3D printed polyprintlets.
Sarah J. Trenfield,Hui Xian Tan,Alvaro Goyanes,David Wilsdon,Martin Rowland,Simon Gaisford,Simon Gaisford,Abdul Basit,Abdul Basit +8 more
TL;DR: For the first time, a non-destructive, RTR quality control of two separate active ingredients in a single 3D printed drug product using NIR spectroscopy is reported, overcoming a major barrier to the integration of 3D printing into clinical practice.
Journal ArticleDOI
Chemometrics and in-line near infrared spectroscopic monitoring of a biopharmaceutical Chinese hamster ovary cell culture: prediction of multiple cultivation variables.
TL;DR: The capability for inline prediction of multiple cultivation variables during bioprocess monitoring is underlines and PCA was found to be a significant tool in identifying batch homogeneity between lots and in detecting abnormal fermentation runs.
Journal ArticleDOI
Process monitoring and visualization solutions for hot-melt extrusion: a review.
TL;DR: The objective of this review is to provide an overview and evaluation of the available process analytical techniques which can be applied in hot‐melt extrusion.
References
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Book
Neural Networks: A Comprehensive Foundation
TL;DR: Thorough, well-organized, and completely up to date, this book examines all the important aspects of this emerging technology, including the learning process, back-propagation learning, radial-basis function networks, self-organizing systems, modular networks, temporal processing and neurodynamics, and VLSI implementation of neural networks.
Journal ArticleDOI
Classification and Regression Trees.
Book
Classification and regression trees
TL;DR: The methodology used to construct tree structured rules is the focus of a monograph as mentioned in this paper, covering the use of trees as a data analysis method, and in a more mathematical framework, proving some of their fundamental properties.
Journal ArticleDOI
Nearest neighbor pattern classification
Thomas M. Cover,Peter E. Hart +1 more
TL;DR: The nearest neighbor decision rule assigns to an unclassified sample point the classification of the nearest of a set of previously classified points, so it may be said that half the classification information in an infinite sample set is contained in the nearest neighbor.