Adiponectin action: a combination of endocrine and autocrine/paracrine effects.
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TLDR
regulation of adiponectin production, its mechanism of action via receptor isoforms and signaling pathways, and its principal physiological effects (i.e., metabolic and cardiovascular) are discussed.Abstract:
The widespread physiological actions of adiponectin have now been well characterized as clinical studies and work in animal models have established strong correlations between circulating adiponectin levels and various disease-related outcomes. Thus, conventional thinking attributes many of adiponectins beneficial effects to endocrine actions of adipose-derived adiponectin. However, it is now clear that several tissues can themselves produce adiponectin and there is growing evidence that locally produced adiponectin can mediate functionally important autocrine or paracrine effects. In this review article we discuss regulation of adiponectin production, its mechanism of action via receptor isoforms and signaling pathways and its principal physiological effects (ie. metabolic and cardiovascular). The role of endocrine actions of adiponectin and changes in local production of adiponectin or its receptors in whole body physiology is discussed.read more
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Adiponectin, driver or passenger on the road to insulin sensitivity?
Risheng Ye,Philipp E. Scherer +1 more
TL;DR: Recent findings in the field are summarized and the rodent studies that suggest a causal relationship between adiponectin levels in plasma and systemic insulin sensitivity in perspective are brought in perspective with the currently available data on the clinical side.
Journal ArticleDOI
Adipose tissue and its role in organ crosstalk.
TL;DR: To depict the endocrine crosstalk between adipose tissue with skeletal muscle, the cardiovascular system and the pancreas, the main findings regarding the direct effects of adiponectin, leptin, DPP4 and visfatin on skeletal muscle insulin resistance, cardiovascular function and β‐cell growth and function are reported.
Journal ArticleDOI
What is the role of adiponectin in obesity related non-alcoholic fatty liver disease?
TL;DR: The pathogenetic role, potential therapeutic benefits, and evidence that adiponectin decreases hepatic and systematic insulin resistance, and attenuates liver inflammation and fibrosis in non-alcoholic fatty liver disease are analyzed systematically.
Journal ArticleDOI
Biomarkers of insulin sensitivity and insulin resistance: Past, present and future
TL;DR: In this article, a review discusses potential biomarkers including adiponectin, RBP4, chemerin, A-FABP, FGF21, fetuin-A, myostatin, IL-6, and irisin, all of which may play significant roles in determining insulin sensitivity.
Journal ArticleDOI
ACE2/Ang 1-7 axis: A critical regulator of epicardial adipose tissue inflammation and cardiac dysfunction in obesity.
TL;DR: The important interpretation of the novel of ACE2/Ang 1-7 pathway in obesity associated cardiac dysfunction is discussed, which reduces the obesity associated heart dysfunction predominantly via its role in adiponectin expression and attenuation of epicardial adipose tissue inflammation.
References
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Journal ArticleDOI
Adipose Tissue Gene Expression of Adiponectin, Tumor Necrosis Factor-α and Leptin in Metabolic Syndrome Patients with Coronary Artery Disease
Selçuk Görmez,Ayse Demirkan,Fatmahan Atalar,Baris Caynak,Refik Erdim,Volkan Sozer,Demet Günay,Bellhan Akpinar,Ugur Ozbek,Ahmet Sevim Buyukdevrim +9 more
TL;DR: It is demonstrated that TNF-α and leptin gene expressions increase prominently in the EAT, PAT and SAT while adiponectin gene expression decreases significantly in EAT and PAT in MS patients with CAD.
Journal ArticleDOI
Protective effect of epicardial adiponectin on atrial fibrillation following cardiac surgery.
Antonios Kourliouros,Kalypso Karastergiou,Justin Nowell,Philemon Gukop,Morteza Tavakkoli Hosseini,Oswaldo Valencia,Vidya Mohamed Ali,Marjan Jahangiri +7 more
TL;DR: Increased epicardial adiponectin is associated with maintenance of sinus rhythm following cardiac surgery, which reinforces the inflammatory hypothesis in the pathogenesis of postoperative AF and may represent a novel therapeutic target for its effective prevention.
Journal ArticleDOI
PARP-1 suppresses adiponectin expression through poly(ADP-ribosyl)ation of PPARγ in cardiac fibroblasts
TL;DR: ParP-1 inhibits adiponectin and AdipoR1 expression as well as PPar gamma transactivation through poly(ADP-ribosyl)ation of PPAR gamma in cultured rat cardiac fibroblasts.
Journal ArticleDOI
Serum levels of hepatoprotective peptide adiponectin in non-alcoholic fatty liver disease.
Cem Aygun,Omer Senturk,Saadettin Hulagu,Suleyman Uraz,Altay Celebi,Tolga Konduk,Birsen Mutlu,Zeynep Cantürk +7 more
TL;DR: Serum adiponectin levels are significantly lower in NAFLD patients with elevated liver enzymes, and non-alcoholic steatohepatitis patients show lower levels of adip onectin with higher grades of inflammation.
Journal ArticleDOI
Adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the Québec Family Study
Ruth J. F. Loos,Stéphanie Ruchat,Tuomo Rankinen,Angelo Tremblay,Louis Pérusse,Claude Bouchard +5 more
TL;DR: Previous findings that the ADIPOQ 45T-->G variant contributes to overall fatness and abdominal obesity are confirmed and variants in the promoter region of both ADIPOR genes contribute to substrate oxidation.
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