Adiponectin action: a combination of endocrine and autocrine/paracrine effects.
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TLDR
regulation of adiponectin production, its mechanism of action via receptor isoforms and signaling pathways, and its principal physiological effects (i.e., metabolic and cardiovascular) are discussed.Abstract:
The widespread physiological actions of adiponectin have now been well characterized as clinical studies and work in animal models have established strong correlations between circulating adiponectin levels and various disease-related outcomes. Thus, conventional thinking attributes many of adiponectins beneficial effects to endocrine actions of adipose-derived adiponectin. However, it is now clear that several tissues can themselves produce adiponectin and there is growing evidence that locally produced adiponectin can mediate functionally important autocrine or paracrine effects. In this review article we discuss regulation of adiponectin production, its mechanism of action via receptor isoforms and signaling pathways and its principal physiological effects (ie. metabolic and cardiovascular). The role of endocrine actions of adiponectin and changes in local production of adiponectin or its receptors in whole body physiology is discussed.read more
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Adiponectin, driver or passenger on the road to insulin sensitivity?
Risheng Ye,Philipp E. Scherer +1 more
TL;DR: Recent findings in the field are summarized and the rodent studies that suggest a causal relationship between adiponectin levels in plasma and systemic insulin sensitivity in perspective are brought in perspective with the currently available data on the clinical side.
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Adipose tissue and its role in organ crosstalk.
TL;DR: To depict the endocrine crosstalk between adipose tissue with skeletal muscle, the cardiovascular system and the pancreas, the main findings regarding the direct effects of adiponectin, leptin, DPP4 and visfatin on skeletal muscle insulin resistance, cardiovascular function and β‐cell growth and function are reported.
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What is the role of adiponectin in obesity related non-alcoholic fatty liver disease?
TL;DR: The pathogenetic role, potential therapeutic benefits, and evidence that adiponectin decreases hepatic and systematic insulin resistance, and attenuates liver inflammation and fibrosis in non-alcoholic fatty liver disease are analyzed systematically.
Journal ArticleDOI
Biomarkers of insulin sensitivity and insulin resistance: Past, present and future
TL;DR: In this article, a review discusses potential biomarkers including adiponectin, RBP4, chemerin, A-FABP, FGF21, fetuin-A, myostatin, IL-6, and irisin, all of which may play significant roles in determining insulin sensitivity.
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ACE2/Ang 1-7 axis: A critical regulator of epicardial adipose tissue inflammation and cardiac dysfunction in obesity.
TL;DR: The important interpretation of the novel of ACE2/Ang 1-7 pathway in obesity associated cardiac dysfunction is discussed, which reduces the obesity associated heart dysfunction predominantly via its role in adiponectin expression and attenuation of epicardial adipose tissue inflammation.
References
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Journal ArticleDOI
Circadian expression of adiponectin and its receptors in human adipose tissue.
Purificación Gómez-Abellán,Cecilia Gómez-Santos,Juan Antonio Madrid,Fermín I. Milagro,Javier Campión,José Alfredo Martínez,Jose M. Ordovas,Marta Garaulet +7 more
TL;DR: Correlation analyses between the genetic circadian oscillation and components of the metabolic syndrome revealed that adiposity and abdominal obesity correlated with a decrease in adiponectin and adip onectin receptors ADIPOR1 and ADIPor2 amplitude.
Journal ArticleDOI
APPL1 mediates adiponectin-stimulated p38 MAPK activation by scaffolding the TAK1-MKK3-p38 MAPK pathway
TL;DR: The study demonstrated that the TAK1-MKK3 cascade mediates adiponectin signaling and uncovers a scaffolding role of APPL1 in regulating the Tak1- MKK3-p38 MAPK pathway, specifically in response to adiponECTin stimulation.
Journal ArticleDOI
Induction of adiponectin in skeletal muscle of type 2 diabetic mice: In vivo and in vitro studies.
TL;DR: The paradoxical upregulation of adiponectin in muscle of obese and diabetic mice may result from lipotoxicity and related oxidative stress and could be viewed as a local protection to counteract ectopic fat deposition and oxidative damage.
Journal ArticleDOI
Up-regulation of adiponectin, its isoforms and receptors in end-stage kidney disease
TL;DR: IR in ESKD is not explained by the change in isoformic distribution, or by AdipoR down-regulation or dysfunction, but this receptor-ligand axis is up-regulated and may be a beneficial response to the inflammatory milieu of ESKd.
Journal ArticleDOI
Effect of a high-fat diet on 24-hour pattern of circulating adipocytokines in rats.
Pilar Cano,Daniel P. Cardinali,María J. Ríos-Lugo,María P. Fernández-Mateos,Carlos F. Reyes Toso,Ana I. Esquifino +5 more
TL;DR: The results indicate that a high‐fat diet may bring about signs of insulin resistance and mild inflammation in rats, together with the disruption in daily variations of circulating insulin and ghrelin, and of several adipocytokines including leptin, adiponectin, IL‐1,IL‐6, TNFα, and MCP‐1.
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