Adult c-kitpos Cardiac Stem Cells Are Necessary and Sufficient for Functional Cardiac Regeneration and Repair
Georgina M. Ellison,Carla Vicinanza,Carla Vicinanza,Andrew J. Smith,Iolanda Aquila,Angelo Leone,Cheryl D. Waring,Beverley J. Henning,Giuliano Giuseppe Stirparo,Roberto Papait,Marzia Scarfò,Valter Agosti,Giuseppe Viglietto,Gianluigi Condorelli,Gianluigi Condorelli,Ciro Indolfi,Sergio Ottolenghi,Daniele Torella,Daniele Torella,Bernardo Nadal-Ginard,Bernardo Nadal-Ginard +20 more
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TLDR
It is shown that c-kit(pos) eCSCs are necessary and sufficient for the regeneration and repair of myocardial damage and selective suicide of these exogenous CSCs and their progeny abolishes regeneration, severely impairing ventricular performance.About:
This article is published in Cell.The article was published on 2013-08-15 and is currently open access. It has received 483 citations till now. The article focuses on the topics: Regeneration (biology) & Transplantation.read more
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Dynamics of Cell Generation and Turnover in the Human Heart
Olaf Bergmann,Sofia Zdunek,Anastasia Felker,Mehran Salehpour,Kanar Alkass,Samuel Bernard,Staffan L. Sjostrom,Mirosława Szewczykowska,Teresa Jackowska,Cris dos Remedios,Torsten Malm,Michaela Andrä,Ramadan Jashari,Jens R. Nyengaard,Göran Possnert,Stefan Jovinge,Stefan Jovinge,Stefan Jovinge,Henrik Druid,Jonas Frisén +19 more
TL;DR: It is reported that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood.
Journal ArticleDOI
c-kit + cells minimally contribute cardiomyocytes to the heart
Jop H. van Berlo,Onur Kanisicak,Marjorie Maillet,Ronald J. Vagnozzi,Jason Karch,Suh Chin J. Lin,Ryan Middleton,Eduardo Marbán,Jeffery D. Molkentin +8 more
TL;DR: Endogenous c-kit+ cells did produce new cardiomyocytes within the heart, although at a percentage of approximately 0.03 or less, and if a preponderance towards cellular fusion is considered, the percentage falls to belowapproximately 0.008.
Journal ArticleDOI
Resident c-kit(+) cells in the heart are not cardiac stem cells.
Nishat Sultana,Lu Zhang,Jianyun Yan,Jiqiu Chen,Weibin Cai,Shegufta Razzaque,Dongtak Jeong,Wei Sheng,Lei Bu,Mingjiang Xu,Guo Ying Huang,Roger J. Hajjar,Bin Zhou,Anne M. Moon,Chen-Leng Cai +14 more
TL;DR: It is strongly suggested that c-kit+ cells in the murine heart are endothelial cells and not CSCs, which predominantly labels a cardiac endothelial cell population in developing and adult hearts.
Journal ArticleDOI
Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease.
TL;DR: The origins and roles of Fibroblasts in cardiac development, homeostasis and disease are outlined; the involvement of fibroblast in current and emerging clinical interventions are illustrated; and future targets for research and development are identified.
Journal ArticleDOI
Therapeutic approaches for cardiac regeneration and repair
TL;DR: Advances in therapeutic approaches for cardiac repair and regeneration are discussed, including cell-based therapies as well as the use of secretory factors, such as microRNAs and exosomes, direct reprogramming strategies, and gene editing to control cardiac remodelling and redirect the adult heart to a regenerative state, and the future prospects of preclinical and clinical trials of heart regeneration.
References
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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources.
TL;DR: By following this protocol, investigators are able to gain an in-depth understanding of the biological themes in lists of genes that are enriched in genome-scale studies.
Journal ArticleDOI
Bone marrow cells regenerate infarcted myocardium
Donald Orlic,Jan Kajstura,Stefano Chimenti,Igor Jakoniuk,Stacie M. Anderson,Baosheng Li,James Pickel,Ronald D.G. McKay,Bernardo Nadal-Ginard,David M. Bodine,Annarosa Leri,Piero Anversa +11 more
TL;DR: It is indicated that locally delivered bone marrow cells can generate de novo myocardium, ameliorating the outcome of coronary artery disease.
Journal ArticleDOI
Adult Cardiac Stem Cells Are Multipotent and Support Myocardial Regeneration
Antonio Paolo Beltrami,Laura Barlucchi,Daniele Torella,Mathue Baker,Federica Limana,Stefano Chimenti,Hideko Kasahara,Marcello Rota,Ezio Musso,Konrad Urbanek,Annarosa Leri,Jan Kajstura,Bernardo Nadal-Ginard,Piero Anversa +13 more
TL;DR: The existence of Lin(-) c-kit(POS) cells with the properties of cardiac stem cells, which are self-renewing, clonogenic, and multipotent, giving rise to myocytes, smooth muscle, and endothelial cells are reported.
Journal ArticleDOI
Evidence for cardiomyocyte renewal in humans
Olaf Bergmann,Ratan D. Bhardwaj,Samuel Bernard,Sofia Zdunek,Fanie Barnabé-Heider,Stuart Walsh,Joel Zupicich,Kanar Alkass,Bruce A. Buchholz,Henrik Druid,Stefan Jovinge,Jonas Frisén +11 more
TL;DR: The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.
Journal ArticleDOI
lumi: a pipeline for processing Illumina microarray
Pan Du,Warren A. Kibbe,Simon Lin +2 more
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Roberto Bolli,Atul R. Chugh,Domenico D'Amario,John H Loughran,Marcus F. Stoddard,Sohail Ikram,Garth M. Beache,Stephen G. Wagner,Annarosa Leri,Toru Hosoda,Fumihiro Sanada,Julius B Elmore,Polina Goichberg,Donato Cappetta,Naresh K Solankhi,Ibrahim Fahsah,D. Gregg Rokosh,Mark S. Slaughter,Jan Kajstura,Piero Anversa +19 more