Journal ArticleDOI
Advanced precancerous lesions within the GI tract: The molecular background
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TLDR
The challenge ahead lies in the reliable identification of disease progression-specific targets to enable molecular testing in the clinical management of the secondary prevention of gastrointestinal cancers.Abstract:
The mainstream carcinogenic processes involved within the gastrointestinal tract are characterized by phenotypic multistep progression cascades that eventually result in full-blown cancers. In this scenario, the understanding of the molecular dysregulations underlying the precancerous lesions is increasing but still remains incomplete. However, in recent years, the enthusiastic rise of innovative technologies (i.e., next-generation sequencing, high-throughput microarray analysis, mass spectrometry based proteomics) and the unexpected discovery of new classes of biomarkers (i.e., miRNA, long-noncoding RNAs) prompted new strength in the exploration of the accurate and comprehensive molecular characterization of premalignant and malignant neoplastic lesions. The challenge ahead lies in the reliable identification of disease progression-specific targets to enable molecular testing in the clinical management of the secondary prevention of gastrointestinal cancers.read more
Citations
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Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis
Jamie M J Weaver,Caryn S. Ross-Innes,Nicholas B. Shannon,Andy G. Lynch,Tim Forshew,Mariagnese Barbera,Muhammed Murtaza,Chin-Ann Johnny Ong,Pierre Lao-Sirieix,Mark J Dunning,Laura Smith,Mike L. Smith,Charlotte Anderson,Benilton S. Carvalho,Maria O'Donovan,Timothy J. Underwood,Andrew May,Nicola Grehan,Richard H. Hardwick,Jim Davies,Arusha Oloumi,Samuel Aparicio,Carlos Caldas,Matthew D. Eldridge,Paul A.W. Edwards,Nitzan Rosenfeld,Simon Tavaré,Rebecca C. Fitzgerald +27 more
TL;DR: In conclusion, mutations in EAC driver genes generally occur exceptionally early in disease development with profound implications for diagnostic and therapeutic strategies.
Journal ArticleDOI
The stomach in health and disease
Richard H. Hunt,Michael Camilleri,Sheila E. Crowe,Emad M. El-Omar,James G. Fox,Ernst J. Kuipers,Peter Malfertheiner,Kenneth E.L. McColl,David M. Pritchard,Massimo Rugge,Amnon Sonnenberg,Kentaro Sugano,Jan Tack +12 more
TL;DR: A future approach to gastric diseases is provided, underpinned by the concept that a healthy stomach is the gateway to a healthy and balanced host, to reinforce any public health efforts designed to eradicate major Gastric diseases, including stomach cancer.
Journal ArticleDOI
Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer.
Yongfu Shao,Meng Ye,Xiaoming Jiang,Weiliang Sun,Weiliang Sun,Xiaoyun Ding,Xiaoyun Ding,Zhong Liu,Guoliang Ye,Xinjun Zhang,Bingxiu Xiao,Junming Guo +11 more
TL;DR: To identify whether lncRNA‐AA174084 is a potential marker for the early diagnosis of gastric cancer (GC), the authors investigated its levels in tissues, blood, and gastric juices from patients with various stage of Gastric tumorigenesis.
Journal ArticleDOI
Multigene mutational profiling of cholangiocarcinomas identifies actionable molecular subgroups
Michele Simbolo,Matteo Fassan,Andrea Ruzzenente,Andrea Mafficini,Laura D. Wood,Vincenzo Corbo,Davide Melisi,Giuseppe Malleo,Caterina Vicentini,Giorgio Malpeli,Davide Antonello,Nicola Sperandio,Paola Capelli,Anna Tomezzoli,Calogero Iacono,Rita T. Lawlor,Claudio Bassi,Ralph H. Hruban,Alfredo Guglielmi,Giampaolo Tortora,Filippo de Braud,Aldo Scarpa +21 more
TL;DR: This study identified molecular subgroups of cholangiocarcinomas that can be explored for specific drug targeting in clinical trials and identified tumour stage and TP53 mutations as independent predictors of survival.
Journal ArticleDOI
Gastric Cancer as Preventable Disease
Massimo Rugge,Robert M. Genta,Francesco Di Mario,Emad M. El-Omar,Hashem B. El-Serag,Matteo Fassan,Richard H. Hunt,Ernst J. Kuipers,Peter Malfertheiner,Kentaro Sugano,David Y. Graham +10 more
TL;DR: A well‐understood natural history provides the clinicopathologic rationale for primary and secondary cancer prevention strategies and demonstrates that combined primary (H pylori eradication) and secondary prevention efforts may prevent or limit the progression of gastric oncogenesis.
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