Andrea Ruzzenente

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: Through exomic sequencing of 32 intrahepatic cholangiocarcinomas, frequent inactivating mutations in multiple chromatin-remodeling genes are discovered (including BAP1, ARID1A and PBRM1), and mutation in one of these genes occurred in almost half of the carcinomas sequenced.

TL;DR: It is identified that the MF + PI type tumors were significantly associated with negative prognostic factors, such as the involvement of extrahepatic bile ducts, the presence of lymph nodes metastases, the Presence of macroscopic vascular invasion, and positive resection margins were significant related to survival.

TL;DR: The aim of this review is to identify the limits for a safe liver resection in patients with normal liver and injured liver (cirrhosis, cholestasis, steatosis and post-chemotherapy liver injury) and to investigate the different risk factors related to the occurrence of PHLF.

TL;DR: In this article, the authors compared the experience of two different surgical units in the treatment of hepatocellular carcinoma (HCC) on cirrhosis with resection or percutaneous radiofrequency ablation (RFA), respectively.