Journal ArticleDOI
Aging of Hepatitis C Virus (HCV)-Infected Persons in the United States: A Multiple Cohort Model of HCV Prevalence and Disease Progression
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This article is published in Yearbook of Gastroenterology.The article was published on 2010-01-01. It has received 584 citations till now. The article focuses on the topics: Hepatitis C virus.read more
Citations
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Emerging therapies for the treatment of hepatitis C
TL;DR: Significant further improvements are on the horizon, which may well cure virtually all hepatitis C patients with an all‐oral, interferon‐free regimen in the very near future.
Journal ArticleDOI
Anti-fibrotic therapy: Lost in translation?
TL;DR: The field is now moving more quickly towards clinical translation, driven by thoughtful preclinical validation, a better study design and improved surrogate readouts using currently available methodologies, and upcoming novel biomarkers and imaging technologies will soon permit a more exact and efficient assessment of fibrosis progression and regression.
Journal ArticleDOI
Identifying barriers to hepatocellular carcinoma surveillance in a national sample of patients with cirrhosis.
David S. Goldberg,Tamar H. Taddei,Marina Serper,Rajni Mehta,Eric Dieperink,Ayse Aytaman,Michelle Baytarian,Rena K. Fox,Kristel Hunt,Marcos C. Pedrosa,Christine Pocha,Adriana Valderrama,David E. Kaplan +12 more
TL;DR: The responsibility for suboptimal surveillance rests with patients, providers, and the overall health care system; several measures can be implemented to potentially increase HCC surveillance, including increasing patient–specialist visits and minimizing appointment lead time.
Journal ArticleDOI
Chemoembolization for hepatocellular carcinoma.
TL;DR: Data from a large phase II randomized, double-blind, placebo-controlled trial have shown that the concurrent administration of DEB-TACE and sorafenib has a manageable safety profile and suggested that time to progression and time to vascular invasion or extrahepatic spread may be improved with respect to DEB -TACE alone.
Journal ArticleDOI
Short-term risk of hepatocellular carcinoma after hepatitis C virus eradication following direct-acting anti-viral treatment.
Eiichi Ogawa,Norihiro Furusyo,H. Nomura,Kazufumi Dohmen,Nobuhiko Higashi,K. Takahashi,Akira Kawano,Koichi Azuma,Takeaki Satoh,Makoto Nakamuta,Toshimasa Koyanagi,Michio Kato,Shinji Shimoda,Eiji Kajiwara,Jun Hayashi +14 more
TL;DR: With the development of direct‐acting anti‐virals (DAAs), almost all patients with chronic hepatitis C virus (HCV) infection can achieve sustained viral response (SVR).
References
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Journal ArticleDOI
Aging of Hepatitis C Virus (HCV)-Infected Persons in the United States: A Multiple Cohort Model of HCV Prevalence and Disease Progression
TL;DR: Prevalence of hepatitis C cirrhosis and its complications will continue to increase through the next decade and will mostly affect those older than 60 years of age, but wider application of antiviral treatment and better responses with new agents could significantly reduce the impact of this disease in coming years.
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