Journal ArticleDOI
Aging of Hepatitis C Virus (HCV)-Infected Persons in the United States: A Multiple Cohort Model of HCV Prevalence and Disease Progression
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This article is published in Yearbook of Gastroenterology.The article was published on 2010-01-01. It has received 584 citations till now. The article focuses on the topics: Hepatitis C virus.read more
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Journal ArticleDOI
HCV Eradication with Direct-Acting Antivirals Does Not Impact HCC Progression on the Waiting List or HCC Recurrence after Liver Transplantation.
Juliet Emamaullee,Juliet Emamaullee,Mariusz Bral,Glenda Meeberg,Aldo J. Montano-Loza,Vincent G. Bain,Kelly W. Burak,David L. Bigam,A. M. James Shapiro,Norman M. Kneteman +9 more
TL;DR: It is suggested that HCV eradication pre-LT does not significantly impact waitlist time for HCV+ patients with HCC and there was no difference in HCC recurrence rates post- LT, whether patients achieved SVR pre- or post-LT.
Journal ArticleDOI
Biomechanics and functionality of hepatocytes in liver cirrhosis.
TL;DR: It is demonstrated that the biomechanical properties of hepatocytes are correlated with their functions, and that hepatic dysfunction can be restored through modulation of the cellular biomechanics, and the hepatocyte functionality appears to be regulated through a crosstalk between the Rho and Akt signaling.
Journal ArticleDOI
Excess mortality rate associated with hepatitis C virus infection: A community-based cohort study in rural Egypt
Aya Mostafa,Yusuke Shimakawa,Ahmed Medhat,Nabiel Mikhail,Cédric B. Chesnais,Cédric B. Chesnais,Naglaa Arafa,I. Bakr,Mostafa El Hoseiny,Mai El-Daly,Gamal Esmat,Mohamed S. Abdel-Hamid,Mostafa K. Mohamed,Arnaud Fontanet,Arnaud Fontanet +14 more
TL;DR: Use of a highly potent new antiviral agent to treat all villagers with positive HCV RNA may reduce all-cause mortality rate by up to 5% and hepatic mortality byUp to 40% in rural Egypt.
Journal ArticleDOI
Sofosbuvir/velpatasvir regimen promises an effective pan-genotypic hepatitis C virus cure.
TL;DR: The safety and efficacy of sofosbuvir/velpatasvir combination regimen for all HCV genotypes is reviewed, but does need to be administered with caution in patients receiving certain medications or with certain diseases.
Journal ArticleDOI
Special populations: treating hepatitis C in patients with decompensated cirrhosis and/or advanced renal impairment.
TL;DR: It is shown that distinct interferon‐free treatments can achieve favourable sustained virological response rates in patients with decompensated cirrhosis and severe renal impairment, and pitfalls and special considerations as well as new emerging challenges in an era of interferons‐free regimens are presented.
References
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Journal ArticleDOI
Aging of Hepatitis C Virus (HCV)-Infected Persons in the United States: A Multiple Cohort Model of HCV Prevalence and Disease Progression
TL;DR: Prevalence of hepatitis C cirrhosis and its complications will continue to increase through the next decade and will mostly affect those older than 60 years of age, but wider application of antiviral treatment and better responses with new agents could significantly reduce the impact of this disease in coming years.
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