Journal ArticleDOI
Aging of Hepatitis C Virus (HCV)-Infected Persons in the United States: A Multiple Cohort Model of HCV Prevalence and Disease Progression
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This article is published in Yearbook of Gastroenterology.The article was published on 2010-01-01. It has received 584 citations till now. The article focuses on the topics: Hepatitis C virus.read more
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Journal ArticleDOI
Some considerations on the predictions of pharmacokinetic alterations in subjects with liver disease
TL;DR: A list of marketed drugs was examined with the aim to identify compound PK characteristics potentially correlated to the extent of PK changes in LD and extensive renal elimination was the only predictor of the lack of significant changes in PK in subjects with LD.
Journal ArticleDOI
HIV-hepatitis C virus co-infection in the era of direct-acting antivirals.
TL;DR: Improvements in direct-acting antivirals have now entered clinical practice and others have reached advanced stages of clinical development, but physicians must be aware of the differences between theseDAAs, the patient characteristics that play a role on the effectiveness of these medications, and the drug-drug interactions these DAAs may have with existing HIV antiretroviral therapies.
Journal Article
Antiviral Therapy in Elderly Patients With Hepatitis C Virus Infection.
TL;DR: Analysis of the current literature shows that direct-acting antiviral agents have been effective, well tolerated, and safe in the elderly population, and this article highlights the efficacy and safety differences in interferon-based therapy and interferons-free regimens for elderly patients with HCV infection.
Journal ArticleDOI
Elbasvir/Grazoprevir in People With Hepatitis C Genotype 1 Infection and Child-Pugh Class B Cirrhosis: The C-SALT Study.
Ira M. Jacobson,Ira M. Jacobson,Fred Poordad,Roberto J. Firpi-Morell,Gregory T. Everson,Elizabeth C. Verna,S. Bhanja,Peggy Hwang,Luzelena Caro,Michael N. Robertson,Edgar D. Charles,Edgar D. Charles,Heather L. Platt +12 more
TL;DR: Although EBR plus reduced-dose GZR is not available for people with CP-B cirrhosis, these results complement phase 2/3 trial data and real-world experience with EBR/GZR and suggest it was highly effective and well tolerated in a traditionally hard-to-treat population.
Journal ArticleDOI
Outcomes after sofosbuvir-containing regimens for hepatitis C virus in patients with decompensated cirrhosis: a real-world study
Fanpu Ji,Wenjun Wang,Shuangsuo Dang,Shengbang Wang,Burong Li,Dan Bai,Wenxue Zhao,Hong Deng,Changyin Tian,Zongfang Li +9 more
TL;DR: Sofosbuvir-containing regimens are effective in Chinese HCV patients with decompensated cirrhosis, regardless of baseline characteristics, as demonstrated by a high rate of SVR 12, as well as improvement in liver function.
References
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Journal ArticleDOI
Aging of Hepatitis C Virus (HCV)-Infected Persons in the United States: A Multiple Cohort Model of HCV Prevalence and Disease Progression
TL;DR: Prevalence of hepatitis C cirrhosis and its complications will continue to increase through the next decade and will mostly affect those older than 60 years of age, but wider application of antiviral treatment and better responses with new agents could significantly reduce the impact of this disease in coming years.
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