Journal ArticleDOI
Aging of Hepatitis C Virus (HCV)-Infected Persons in the United States: A Multiple Cohort Model of HCV Prevalence and Disease Progression
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This article is published in Yearbook of Gastroenterology.The article was published on 2010-01-01. It has received 584 citations till now. The article focuses on the topics: Hepatitis C virus.read more
Citations
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The Intersection Of Chronic Hepatitis C Infection And Cardiovascular Disease
TL;DR: It is found that, on average, treatment with at least 30 days of a statin was associated with a lower HCV viral load than that observed in those unexposed to statins, and while long-term follow up was not available, statin therapy was not associated with an increased incidence of liver injury.
Journal ArticleDOI
Is expert opinion reliable when estimating transition probabilities? The case of HCV-related cirrhosis in Egypt
Anthony Cousien,Anthony Cousien,Dorothée Obach,Dorothée Obach,Sylvie Deuffic-Burban,Sylvie Deuffic-Burban,Aya Mostafa,Gamal Esmat,Valérie Canva,Mohamed El Kassas,Mohammad El-Sayed,Wagida A. Anwar,Arnaud Fontanet,Arnaud Fontanet,Mostafa K. Mohamed,Yazdan Yazdanpanah +15 more
TL;DR: The results show that eliciting expert opinions is not suited for determining the natural history of diseases due to practitioners’ difficulties in evaluating quantities and cognitive bias occurring during this type of study.
Journal ArticleDOI
Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro.
TL;DR: The role of amantadine in suppressing proliferation and inducing apoptosis in HCC cells is emphasized, advocating its use as a novel tumor-suppressive therapeutic candidate.
Journal ArticleDOI
Treatment of hepatitis C in patients with HIV
Lydia Tang,Shyam Kottilil +1 more
TL;DR: 12 weeks of treatment with the pan-genotypic HCV genotype 1–4 combination tablet, a secondgeneration NS3/4A protease inhibitor, and elbasvir, an NS5A inhibitor, paved the way to expansion of HCV treatment eligibility for patients with HIV and HCV coinfection.
Journal ArticleDOI
Predicting Discontinuation of Pegylated Interferon as a Result of Lack of Efficacy in United States Veterans With Chronic Hepatitis C on Dual Therapy
Richard E. Nelson,Robert Hoop,Eli Korner,Scott L. DuVall,Candace Hayden,Kristin Knippenberg,Timothy R. Morgan,Prashant Pandya,Jian Han,Joanne LaFleur +9 more
TL;DR: Patient characteristics that were significant predictors of discontinuation as a result of lack of efficacy (LOE) in a national database of US veterans with genotypes 1 and 4 are identified and future work should focus on determining whether these characteristics are also predictive of triple-therapy LOE discontinuations.
References
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Journal ArticleDOI
Aging of Hepatitis C Virus (HCV)-Infected Persons in the United States: A Multiple Cohort Model of HCV Prevalence and Disease Progression
TL;DR: Prevalence of hepatitis C cirrhosis and its complications will continue to increase through the next decade and will mostly affect those older than 60 years of age, but wider application of antiviral treatment and better responses with new agents could significantly reduce the impact of this disease in coming years.
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