Journal ArticleDOI
Aging of Hepatitis C Virus (HCV)-Infected Persons in the United States: A Multiple Cohort Model of HCV Prevalence and Disease Progression
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This article is published in Yearbook of Gastroenterology.The article was published on 2010-01-01. It has received 584 citations till now. The article focuses on the topics: Hepatitis C virus.read more
Citations
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Journal ArticleDOI
Interferon-free therapies for chronic hepatitis C: toward a hepatitis C virus-free world?
TL;DR: If the problem of the high cost is overcome, interferon-free therapies will lead to what has long been a chimera, namely, an HCV-free world.
Journal ArticleDOI
Molecular Functions of Thyroid Hormones and Their Clinical Significance in Liver-Related Diseases
TL;DR: Recent studies focusing on the roles of THs and TRs in several disorders, in particular, liver diseases are reviewed and the potential therapeutic applications ofTHs and underlying molecular mechanisms are discussed.
Journal ArticleDOI
Diabetes Is Associated with Clinical Decompensation Events in Patients with Cirrhosis.
Tsai-Ling Liu,Justin G. Trogdon,Morris Weinberger,Morris Weinberger,Bruce J. Fried,A. Sidney Barritt +5 more
TL;DR: Careful management of diabetes in patients with liver disease may reduce the risk of clinical decompensation in this population of working-aged insured patients dually diagnosed with compensated cirrhosis and diabetes.
Journal ArticleDOI
Daclatasvir and asunaprevir plus peginterferon alfa and ribavirin in HCV genotype 1 or 4 non-responders
Donald M. Jensen,Kenneth E. Sherman,Christophe Hézode,Stanislas Pol,Stefan Zeuzem,Victor de Ledinghen,Albert Tran,Magdy Elkhashab,Ziad Younes,Marcelo Kugelmas,Stefan Mauss,Gregory T. Everson,Velimir A. Luketic,John M. Vierling,Lawrence Serfaty,Maurizia Rossana Brunetto,Jeong Heo,David I. Bernstein,Fiona McPhee,Delphine Hennicken,Patricia Mendez,Eric Hughes,Stephanie Noviello +22 more
TL;DR: Daclatasvir plus asunaprevir and peginterferon/ribavirin demonstrated high rates of SVR12 in genotype 1- or 4-infected prior null or partial responders and the combination was well tolerated and no additional safety and tolerability concerns were observed compared with pegin terferon-alfa-2a and ribavirin regimens.
Journal ArticleDOI
Obeticholic acid for the treatment of primary biliary cholangitis
Ahmad H. Ali,Keith D. Lindor +1 more
TL;DR: Obeticholic acid (OCA, 6-ECDCA, or INT-747), a first-in-class FXR agonist, has been examined in PBC patients with inadequate response to UDCA, and shown promising results, particularly on reduction of serum alkaline phosphatase (ALP, an important prognostic marker in P BC).
References
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Journal ArticleDOI
Aging of Hepatitis C Virus (HCV)-Infected Persons in the United States: A Multiple Cohort Model of HCV Prevalence and Disease Progression
TL;DR: Prevalence of hepatitis C cirrhosis and its complications will continue to increase through the next decade and will mostly affect those older than 60 years of age, but wider application of antiviral treatment and better responses with new agents could significantly reduce the impact of this disease in coming years.
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