Agreement Between Magnetic Resonance Imaging Proton Density Fat Fraction Measurements and Pathologist-Assigned Steatosis Grades of Liver Biopsies From Adults With Nonalcoholic Steatohepatitis.
Michael S. Middleton,Elhamy Heba,Catherine A. Hooker,Mustafa R. Bashir,Kathryn J. Fowler,Kumar Sandrasegaran,Elizabeth M. Brunt,David E. Kleiner,Edward Doo,Mark L. Van Natta,Joel E. Lavine,Brent A. Neuschwander-Tetri,Arun J. Sanyal,Rohit Loomba,Claude B. Sirlin +14 more
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TLDR
Based on data from a phase 2 randomized controlled trial of adults with NASH, PDFF estimated by MRI scanners of different field strength and at different sites, accurately classifies grades and changes in hepatic steatosis when histologic analysis of biopsies is used as a reference.About:
This article is published in Gastroenterology.The article was published on 2017-09-01 and is currently open access. It has received 193 citations till now. The article focuses on the topics: Steatosis.read more
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Treatments of nonalcoholic fatty liver disease in adults who have no other illness: A Review article.
TL;DR: This article aimed to review randomized controlled trials that evaluate the effects of pharmacological agents on NAFLD adults without other illness to provide the most effective treatments.
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A pilot study of ex-vivo MRI-PDFF of donor livers for assessment of steatosis and predicting early graft dysfunction
Sanjaya K. Satapathy,Sanjaya K. Satapathy,Sanjaya K. Satapathy,Humberto C. Gonzalez,Humberto C. Gonzalez,Humberto C. Gonzalez,Jason M. Vanatta,Jason M. Vanatta,Jason M. Vanatta,Andrew Dyer,Wesley Angel,Simonne S. Nouer,Mehmet Kocak,Satish Kedia,Yu Jiang,Ian Clark,Nour Yadak,Nosratollah Nezakagtoo,Nosratollah Nezakagtoo,Ryan A. Helmick,Ryan A. Helmick,Peter Horton,Peter Horton,Luis Campos,Luis Campos,Uchenna Agbim,Uchenna Agbim,Benedict Maliakkal,Benedict Maliakkal,Daniel Maluf,Daniel Maluf,Satheesh Nair,Satheesh Nair,Hollis H. Halford,James D. Eason,James D. Eason +35 more
TL;DR: In this pilot study, MRI-PDFF imaging showed potential utility in quantifying hepatic steatosis ex-vivo donor liver evaluation and the ability to predict EAD related to severe allograft Steatosis in the recipient.
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Quantification of liver fat deposition in obese and diabetic patients: A pilot study on the correlation with myocardium and periapical fat content☆
TL;DR: In this paper , the contents of liver and cardiac fat with varying degrees of NAFLD in an obese group and a type 2 diabetes mellitus (T2DM) group were quantitatively measured in regions of interest of the liver, myocardium, and periapical adipose tissue.
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Assessing breast density using the chemical-shift encoding-based proton density fat fraction in 3-T MRI
Tabea Borde,Mingming Wu,Stefan Ruschke,Christof Boehm,Jonathan K Stelter,Kilian Weiss,Stephan Metz,M. A. Makowski,Dimitrios C. Karampinos,Eva M. Fallenberg +9 more
TL;DR: In this article , the proton density fat fraction (PDFF) was used as a quantitative biomarker for fat tissue concentration in breast MRI and correlate mean breast PDFF to mammography.
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Metabolic Stress Index Including Mitochondrial Biomarker for Noninvasive Diagnosis of Hepatic Steatosis
Jae Seung Chang,Jhii Hyun Ahn,Seong Hee Kang,Sang Baek Koh,Jang Young Kim,Soon Koo Baik,Jimi Huh,Samuel S. Lee,Moon Young Kim,Kyu Sang Park +9 more
TL;DR: MSI-S, as a novel non-invasive index, based on mitochondrial stress biomarker FGF21 effectively predicted steatosis, and may increase the population that could be excluded from further evaluation, reducing unnecessary invasive investigations more effectively than other indices.
References
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
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Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study
Christopher D. Williams,Joel Z. Stengel,Michael I. Asike,Dawn M. Torres,Janet Shaw,Maricela Contreras,Cristy L. Landt,Stephen A. Harrison +7 more
TL;DR: Prevalence of nonalcoholic fatty liver disease and NASH is higher than estimated previously and Hispanics and patients with diabetes are at greatest risk for both NAFLD and NASh.
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Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
Brent A. Neuschwander-Tetri,Rohit Loomba,Arun J. Sanyal,Joel E. Lavine,Mark L. Van Natta,Manal F. Abdelmalek,Naga Chalasani,Srinivasan Dasarathy,Anna Mae Diehl,Bilal Hameed,Kris V. Kowdley,Arthur J. McCullough,Norah A. Terrault,Jeanne M. Clark,James Tonascia,Elizabeth M. Brunt,David E. Kleiner,Edward Doo +17 more
TL;DR: Obeticholic acid improved the histological features of non-alcoholic steatohepatitis, but its long-term benefits and safety need further clarification.
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Estimation of Error Rates in Discriminant Analysis
TL;DR: In this article, several methods of estimating error rates in discriminant analysis are evaluated by sampling methods, and two methods in most common use are found to be significantly poorer than some new methods that are proposed.
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The global NAFLD epidemic
Rohit Loomba,Arun J. Sanyal +1 more
TL;DR: The similarities and differences in the epidemiology of NAFLD in different regions of the world are discussed and the potential role of genetics and insulin resistance in disease progression is also presented.