Agreement Between Magnetic Resonance Imaging Proton Density Fat Fraction Measurements and Pathologist-Assigned Steatosis Grades of Liver Biopsies From Adults With Nonalcoholic Steatohepatitis.
Michael S. Middleton,Elhamy Heba,Catherine A. Hooker,Mustafa R. Bashir,Kathryn J. Fowler,Kumar Sandrasegaran,Elizabeth M. Brunt,David E. Kleiner,Edward Doo,Mark L. Van Natta,Joel E. Lavine,Brent A. Neuschwander-Tetri,Arun J. Sanyal,Rohit Loomba,Claude B. Sirlin +14 more
Reads0
Chats0
TLDR
Based on data from a phase 2 randomized controlled trial of adults with NASH, PDFF estimated by MRI scanners of different field strength and at different sites, accurately classifies grades and changes in hepatic steatosis when histologic analysis of biopsies is used as a reference.About:
This article is published in Gastroenterology.The article was published on 2017-09-01 and is currently open access. It has received 193 citations till now. The article focuses on the topics: Steatosis.read more
Citations
More filters
Journal ArticleDOI
Digital liver biopsy: Bio-imaging of fatty liver for translational and clinical research.
Marcello Mancini,Paul Summers,Francesco Faita,Maurizia Rossana Brunetto,Francesco Callea,Andrea De Nicola,Nicole Di Lascio,Fabio Farinati,Amalia Gastaldelli,Bruno Gridelli,Peppino Mirabelli,Emanuele Neri,Piero A. Salvadori,Eleni Rebelos,Claudio Tiribelli,Luca Valenti,Marco Salvatore,Ferruccio Bonino +17 more
TL;DR: A multi-Author review of the issue with special focus on fatty liver is provided, hoping that the combination of digital, liquid and histologic liver biopsies will provide an innovative synergistic tri-dimensional approach to identifying new aetiologies, diagnostic and prognostic biomarkers and therapeutic targets for the optimization of personalized therapy of liver diseases and liver cancer.
Journal ArticleDOI
The relationship between pancreas steatosis and the risk of metabolic syndrome and insulin resistance in Chinese adolescents with concurrent obesity and non-alcoholic fatty liver disease.
Chileka Chiyanika,Dorothy F.Y. Chan,Steve C. N. Hui,Steve C. N. Hui,Hung-Kwan So,Min Deng,David K.W. Yeung,E. Anthony S. Nelson,Winnie C.W. Chu +8 more
TL;DR: Fatty pancreas is a common finding in adolescents with obesity, with a prevalence rate of 50% in this study cohort, and should not be considered as a benign finding but rather as an imaging biomarker of emerging pancreatic metabolic and endocrine dysfunction.
Journal ArticleDOI
A gathering storm: HIV infection and nonalcoholic fatty liver disease in low and middle-income countries.
Nitin Kapoor,Nitin Kapoor,Jennifer Audsley,Priscilla Rupali,Joe Sasadeusz,Thomas V Paul,Nihal Thomas,Sharon R Lewin,Sharon R Lewin +8 more
TL;DR: The cohort data onNAFLD in HIV is reviewed, the risk factors, pathogenesis of hepatic steatosis, NAFLD and nonalcoholic steatohepatitis are discussed, diagnostic approaches and therapeutic options available for NAFLd in the setting of HIV, and the specific challenges of NAFLDs in HIV for LMICs are discussed.
Journal ArticleDOI
Accuracy and precision of proton density fat fraction measurement across field strengths and scan intervals: A phantom and human study.
TL;DR: Complex‐based chemical shift imaging‐based magnetic resonance imaging (CSE‐MRI) is emerging as a preferred method for noninvasively quantifying proton density fat fraction (PDFF), a promising quantitative imaging biomarker (QIB) for longitudinal hepatic steatosis measurement.
Journal ArticleDOI
Steatosis grading consistency between controlled attenuation parameter and MRI-PDFF in monitoring metabolic associated fatty liver disease.
TL;DR: In this paper, the diagnostic accuracy of steatosis grading between MRI-PDFF and CAP using liver biopsy as standard and to evaluate the value of monitoring changes in steatotic grading with CAP during follow-up utilizing MRIPDFF as a reference.
References
More filters
Journal ArticleDOI
Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
Journal ArticleDOI
Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study
Christopher D. Williams,Joel Z. Stengel,Michael I. Asike,Dawn M. Torres,Janet Shaw,Maricela Contreras,Cristy L. Landt,Stephen A. Harrison +7 more
TL;DR: Prevalence of nonalcoholic fatty liver disease and NASH is higher than estimated previously and Hispanics and patients with diabetes are at greatest risk for both NAFLD and NASh.
Journal ArticleDOI
Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
Brent A. Neuschwander-Tetri,Rohit Loomba,Arun J. Sanyal,Joel E. Lavine,Mark L. Van Natta,Manal F. Abdelmalek,Naga Chalasani,Srinivasan Dasarathy,Anna Mae Diehl,Bilal Hameed,Kris V. Kowdley,Arthur J. McCullough,Norah A. Terrault,Jeanne M. Clark,James Tonascia,Elizabeth M. Brunt,David E. Kleiner,Edward Doo +17 more
TL;DR: Obeticholic acid improved the histological features of non-alcoholic steatohepatitis, but its long-term benefits and safety need further clarification.
Journal ArticleDOI
Estimation of Error Rates in Discriminant Analysis
TL;DR: In this article, several methods of estimating error rates in discriminant analysis are evaluated by sampling methods, and two methods in most common use are found to be significantly poorer than some new methods that are proposed.
Journal ArticleDOI
The global NAFLD epidemic
Rohit Loomba,Arun J. Sanyal +1 more
TL;DR: The similarities and differences in the epidemiology of NAFLD in different regions of the world are discussed and the potential role of genetics and insulin resistance in disease progression is also presented.