Agreement Between Magnetic Resonance Imaging Proton Density Fat Fraction Measurements and Pathologist-Assigned Steatosis Grades of Liver Biopsies From Adults With Nonalcoholic Steatohepatitis.
Michael S. Middleton,Elhamy Heba,Catherine A. Hooker,Mustafa R. Bashir,Kathryn J. Fowler,Kumar Sandrasegaran,Elizabeth M. Brunt,David E. Kleiner,Edward Doo,Mark L. Van Natta,Joel E. Lavine,Brent A. Neuschwander-Tetri,Arun J. Sanyal,Rohit Loomba,Claude B. Sirlin +14 more
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TLDR
Based on data from a phase 2 randomized controlled trial of adults with NASH, PDFF estimated by MRI scanners of different field strength and at different sites, accurately classifies grades and changes in hepatic steatosis when histologic analysis of biopsies is used as a reference.About:
This article is published in Gastroenterology.The article was published on 2017-09-01 and is currently open access. It has received 193 citations till now. The article focuses on the topics: Steatosis.read more
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Noninvasive biomarkers in pediatric nonalcoholic fatty liver disease
TL;DR: In this article , a review of non-invasive biomarkers in pediatric nonalcoholic fatty liver disease (NAFLD) focusing primarily on the diagnostic accuracy of various biomarkers as measured by their area under the receiver operating characteristic, sensitivity, and specificity is presented.
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The Accuracy of Ultrasound Controlled Attenuation Parameter in Diagnosing Hepatic Fat Content
Sebastiana Atzori,Yasmin Pasha,James Maurice,Simon D. Taylor-Robinson,Louise Campbell,Adrian Lim +5 more
TL;DR: In this article , a Controlled Attention Parameter (CAP) score was developed to quantify steatosis. But the performance of CAP is associated with diabetes but not other clinical factors and parameters of the metabolic syndrome, and univariate analysis showed a correlation between CAP and diabetes.
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Surveillance of the progression and assessment of treatment endpoints for nonalcoholic steatohepatitis
Yi-Wen Shi,Jian-Gao Fan +1 more
TL;DR: A review of non-invasive methods for detecting steatosis, steatohepatitis, and fibrosis in patients with NASH is presented in this article , with a focus on the characteristics that should be monitored at follow-up.
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Poor glycaemic control and ectopic fat deposition mediates the increased risk of non-alcoholic steatohepatitis in high-risk populations with type 2 diabetes: Insights from Bayesian-network modelling
T Waddell,Ana I. L. Namburete,P. Duckworth,Alessandro Fichera,Alison Telford,Helena Thomaides-Brears,Daniel J. Cuthbertson,Mark Brady +7 more
TL;DR: In this article , the probability of non-alcoholic steatohepatitis (NASH) in type 2 diabetes patients was investigated using Bayesian networks and probabilistic reasoning.
References
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
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Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study
Christopher D. Williams,Joel Z. Stengel,Michael I. Asike,Dawn M. Torres,Janet Shaw,Maricela Contreras,Cristy L. Landt,Stephen A. Harrison +7 more
TL;DR: Prevalence of nonalcoholic fatty liver disease and NASH is higher than estimated previously and Hispanics and patients with diabetes are at greatest risk for both NAFLD and NASh.
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Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
Brent A. Neuschwander-Tetri,Rohit Loomba,Arun J. Sanyal,Joel E. Lavine,Mark L. Van Natta,Manal F. Abdelmalek,Naga Chalasani,Srinivasan Dasarathy,Anna Mae Diehl,Bilal Hameed,Kris V. Kowdley,Arthur J. McCullough,Norah A. Terrault,Jeanne M. Clark,James Tonascia,Elizabeth M. Brunt,David E. Kleiner,Edward Doo +17 more
TL;DR: Obeticholic acid improved the histological features of non-alcoholic steatohepatitis, but its long-term benefits and safety need further clarification.
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Estimation of Error Rates in Discriminant Analysis
TL;DR: In this article, several methods of estimating error rates in discriminant analysis are evaluated by sampling methods, and two methods in most common use are found to be significantly poorer than some new methods that are proposed.
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The global NAFLD epidemic
Rohit Loomba,Arun J. Sanyal +1 more
TL;DR: The similarities and differences in the epidemiology of NAFLD in different regions of the world are discussed and the potential role of genetics and insulin resistance in disease progression is also presented.