Agreement Between Magnetic Resonance Imaging Proton Density Fat Fraction Measurements and Pathologist-Assigned Steatosis Grades of Liver Biopsies From Adults With Nonalcoholic Steatohepatitis.
Michael S. Middleton,Elhamy Heba,Catherine A. Hooker,Mustafa R. Bashir,Kathryn J. Fowler,Kumar Sandrasegaran,Elizabeth M. Brunt,David E. Kleiner,Edward Doo,Mark L. Van Natta,Joel E. Lavine,Brent A. Neuschwander-Tetri,Arun J. Sanyal,Rohit Loomba,Claude B. Sirlin +14 more
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TLDR
Based on data from a phase 2 randomized controlled trial of adults with NASH, PDFF estimated by MRI scanners of different field strength and at different sites, accurately classifies grades and changes in hepatic steatosis when histologic analysis of biopsies is used as a reference.About:
This article is published in Gastroenterology.The article was published on 2017-09-01 and is currently open access. It has received 193 citations till now. The article focuses on the topics: Steatosis.read more
Citations
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Journal ArticleDOI
Inter-reader agreement of magnetic resonance imaging proton density fat fraction and its longitudinal change in a clinical trial of adults with nonalcoholic steatohepatitis
Jonathan Hooker,Gavin Hamilton,Charlie C. Park,Steven Liao,Tanya Wolfson,Soudabeh Fazeli Dehkordy,Cheng William Hong,Adrija Mamidipalli,Anthony Gamst,Rohit Loomba,Claude B. Sirlin +10 more
TL;DR: Inter-reader agreement for measuring whole-liver PDFF and its longitudinal change is high, and 9- ROI measurements have only slightly lower agreement than 27-ROI measurements.
Journal ArticleDOI
The Additive Values of the Classification of Higher Serum Uric Acid Levels as a Diagnostic Criteria for Metabolic-Associated Fatty Liver Disease
TL;DR: The rationale for SUA being established as another risk factor for metabolic dysfunctions in lean/normal-weight NAFLD–non-MAFLD patients with higher SUA levels is supported.
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Changes in abdominal adipose tissue depots accessed by MRI correlate with hepatic histologic improvement in non-alcoholic steatohepatitis.
Wei Shen,Michael S. Middleton,Guilherme Moura Cunha,Timoteo Delgado,Tanya Wolfson,Anthony Gamst,Kathryn J. Fowler,Adina Alazraki,Andrew T. Trout,Michael A. Ohliger,Shetal N. Shah,Mustafa R. Bashir,David E. Kleiner,Rohit Loomba,Brent A. Neuschwander-Tetri,Arun J. Sanyal,Jane Zhou,Claude B. Sirlin,Joel E. Lavine +18 more
TL;DR: In this paper , a secondary analysis of prospectively acquired data from the multicenter, randomized, placebo-controlled FLINT trial investigated the relationship between reduction in adipose tissue compartment volumes and hepatic histologic improvement.
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Longitudinal changes on liver proton density fat fraction differ between liver segments
Jan Syväri,Daniela Junker,Lisa Patzelt,Katharina Kappo,Loubna Al Sadat,Sonia Erfanian,Marcus R. Makowski,Hans Hauner,Dimitrios C. Karampinos +8 more
TL;DR: Larger PDFFChanges in the right liver lobe were observed compared to PDFF changes in the left liver lobe (LLL) in subjects with both increasing and decreasing mean liver PDFF after one year, in line with the existing literature reporting a heterogeneous spatial distribution of liver fat.
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Deep Learning Techniques for Fatty Liver Using Multi-View Ultrasound Images Scanned by Different Scanners: Development and Validation Study
TL;DR: With deep learning techniques and multi-view ultrasound images, it is potentially possible to replace MRI–PDFF values with deep learning predictions for detecting fatty liver disease and estimating fat fraction values.
References
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
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Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study
Christopher D. Williams,Joel Z. Stengel,Michael I. Asike,Dawn M. Torres,Janet Shaw,Maricela Contreras,Cristy L. Landt,Stephen A. Harrison +7 more
TL;DR: Prevalence of nonalcoholic fatty liver disease and NASH is higher than estimated previously and Hispanics and patients with diabetes are at greatest risk for both NAFLD and NASh.
Journal ArticleDOI
Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
Brent A. Neuschwander-Tetri,Rohit Loomba,Arun J. Sanyal,Joel E. Lavine,Mark L. Van Natta,Manal F. Abdelmalek,Naga Chalasani,Srinivasan Dasarathy,Anna Mae Diehl,Bilal Hameed,Kris V. Kowdley,Arthur J. McCullough,Norah A. Terrault,Jeanne M. Clark,James Tonascia,Elizabeth M. Brunt,David E. Kleiner,Edward Doo +17 more
TL;DR: Obeticholic acid improved the histological features of non-alcoholic steatohepatitis, but its long-term benefits and safety need further clarification.
Journal ArticleDOI
Estimation of Error Rates in Discriminant Analysis
TL;DR: In this article, several methods of estimating error rates in discriminant analysis are evaluated by sampling methods, and two methods in most common use are found to be significantly poorer than some new methods that are proposed.
Journal ArticleDOI
The global NAFLD epidemic
Rohit Loomba,Arun J. Sanyal +1 more
TL;DR: The similarities and differences in the epidemiology of NAFLD in different regions of the world are discussed and the potential role of genetics and insulin resistance in disease progression is also presented.