Agreement Between Magnetic Resonance Imaging Proton Density Fat Fraction Measurements and Pathologist-Assigned Steatosis Grades of Liver Biopsies From Adults With Nonalcoholic Steatohepatitis.
Michael S. Middleton,Elhamy Heba,Catherine A. Hooker,Mustafa R. Bashir,Kathryn J. Fowler,Kumar Sandrasegaran,Elizabeth M. Brunt,David E. Kleiner,Edward Doo,Mark L. Van Natta,Joel E. Lavine,Brent A. Neuschwander-Tetri,Arun J. Sanyal,Rohit Loomba,Claude B. Sirlin +14 more
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TLDR
Based on data from a phase 2 randomized controlled trial of adults with NASH, PDFF estimated by MRI scanners of different field strength and at different sites, accurately classifies grades and changes in hepatic steatosis when histologic analysis of biopsies is used as a reference.About:
This article is published in Gastroenterology.The article was published on 2017-09-01 and is currently open access. It has received 193 citations till now. The article focuses on the topics: Steatosis.read more
Citations
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Journal ArticleDOI
Noninvasive Assessment of Liver Disease in Patients With Nonalcoholic Fatty Liver Disease.
TL;DR: The current state of the noninvasive assessment of liver disease in NAFLD is summarized, and an expert synthesis of how these nonin invasive tools could be utilized in clinical practice is provided.
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EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis – 2021 update
Annalisa Berzigotti,Emmanouil Tsochatzis,Jérôme Boursier,Laurent Castera,Nora Cazzagon,Mireen Friedrich-Rust,Salvatore Petta,Maja Thiele +7 more
TL;DR: In this article, the authors provide the latest update to the EASL Clinical Practice Guidelines on the use of non-invasive tests for the evaluation of liver disease severity and prognosis.
Journal ArticleDOI
NGM282 for treatment of non-alcoholic steatohepatitis: a multicentre, randomised, double-blind, placebo-controlled, phase 2 trial.
Stephen A. Harrison,Mary E. Rinella,Manal F. Abdelmalek,James F. Trotter,Angelo H. Paredes,Hays Arnold,Marcelo Kugelmas,Mustafa R. Bashir,Mark J. Jaros,Lei Ling,Stephen J. Rossi,Alex M. DePaoli,Rohit Loomba +12 more
TL;DR: NGM282 produced rapid and significant reductions in liver fat content with an acceptable safety profile in patients with non-alcoholic steatohepatitis.
Journal ArticleDOI
Noninvasive, Quantitative Assessment of Liver Fat by MRI-PDFF as an Endpoint in NASH Trials.
TL;DR: In this paper, the authors discuss the role and utility of MRI-PDFF as a quantitative and noninvasive imaging-based biomarker in early-phase NASH trials, including potential sample size reduction.
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Liver fat imaging—a clinical overview of ultrasound, CT, and MR imaging
Yingzhen N. Zhang,Kathryn J. Fowler,Gavin Hamilton,Jennifer Y Cui,Ethan Z. Sy,Michelle Balanay,Jonathan Hooker,Nikolaus M. Szeverenyi,Claude B. Sirlin +8 more
TL;DR: MRI proton-density fat fraction is currently the most accurate and precise imaging biomarker to quantify liver steatosis and is the most appropriate noninvasive end point for steatotic reduction in clinical trials and therapy response assessment.
References
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In vivo characterization of the liver fat 1H MR spectrum
Gavin Hamilton,Takeshi Yokoo,Mark Bydder,Irene Cruite,Michael E. Schroeder,Claude B. Sirlin,Michael S. Middleton +6 more
TL;DR: The triglyceride model can characterize human liver fat spectra, which allows more accurate determination of liver fat fraction from MRI and MRS, and agreed closely with spectroscopic measurement.
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Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials
Mazen Noureddin,Jessica Lam,Michael R. Peterson,Michael S. Middleton,Gavin Hamilton,Thuy-Anh Le,Ricki Bettencourt,Christopher Changchien,David A. Brenner,Claude B. Sirlin,Rohit Loomba +10 more
TL;DR: MRI‐ PDFF correlated well with MRS‐PDFF and was more sensitive than the histology‐determined steatosis grade in quantifying increases or decreases in the liver fat content, and could be used to quantify changes in liver fat in future clinical trials.
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World Gastroenterology Organisation global guidelines: Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.
Douglas R. LaBrecque,Zaigham Abbas,Frank Anania,Peter Ferenci,Aamir G. Khan,Khean-Lee Goh,Saeed Hamid,Vasily Isakov,Maribel Lizarzábal,Manuel M. Peñaranda,Juan F.R. Ramos,Shiv Kumar Sarin,Davor Štimac,Alan B. R. Thomson,Muhammed Umar,Justus Krabshuis,Anton LeMair +16 more
TL;DR: Review Team, Douglas R.R. LaBrecque,MD, FACP (chair, USA), Zaigham Abbas, MD, MBBS, FCPS, F RCP, FRCPI,FACP, FACG, AGAF (Pakistan), Frank Anania, MD; Peter Ferenci, MD (Austria), and Anton LeMair,MD (Netherlands)
Journal ArticleDOI
Nonalcoholic Fatty Liver Disease: MR Imaging of Liver Proton Density Fat Fraction to Assess Hepatic Steatosis
An Tang,Justin Tan,Mark Sun,Gavin Hamilton,Mark Bydder,Tanya Wolfson,Anthony Gamst,Michael S. Middleton,Elizabeth M. Brunt,Rohit Loomba,Joel E. Lavine,Jeffrey B. Schwimmer,Claude B. Sirlin +12 more
TL;DR: MR imaging-PDFF showed promise for assessment of hepatic steatosis grade in patients with NAFLD, and was significantly correlated with histologic steatotic grade.
Journal ArticleDOI
Relaxation Effects in the Quantification of Fat using Gradient Echo Imaging
Mark Bydder,Takeshi Yokoo,Gavin Hamilton,Michael S. Middleton,Alyssa D. Chavez,Jeffrey B. Schwimmer,Joel E. Lavine,Claude B. Sirlin +7 more
TL;DR: Quantification of fat has been investigated using images acquired from multiple gradient echoes and results indicate that quantification is most accurate at low flip angles with a small number of echoes (to minimize spectral broadening effects).