Agreement Between Magnetic Resonance Imaging Proton Density Fat Fraction Measurements and Pathologist-Assigned Steatosis Grades of Liver Biopsies From Adults With Nonalcoholic Steatohepatitis.
Michael S. Middleton,Elhamy Heba,Catherine A. Hooker,Mustafa R. Bashir,Kathryn J. Fowler,Kumar Sandrasegaran,Elizabeth M. Brunt,David E. Kleiner,Edward Doo,Mark L. Van Natta,Joel E. Lavine,Brent A. Neuschwander-Tetri,Arun J. Sanyal,Rohit Loomba,Claude B. Sirlin +14 more
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TLDR
Based on data from a phase 2 randomized controlled trial of adults with NASH, PDFF estimated by MRI scanners of different field strength and at different sites, accurately classifies grades and changes in hepatic steatosis when histologic analysis of biopsies is used as a reference.About:
This article is published in Gastroenterology.The article was published on 2017-09-01 and is currently open access. It has received 193 citations till now. The article focuses on the topics: Steatosis.read more
Citations
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The Accuracy and Clinical Relevance of the Multi-echo Dixon Technique for Evaluating Changes to Hepatic Steatosis in Patients with Non-alcoholic Fatty Liver Disease Treated with Formulated Food
TL;DR: ME-Dixon has a good consistency and a correlation with MRS in quantifying the liverfat content and monitoring the treatment effect, which may be used as an accurate indicator for clinical monitoring of changes in the liver fat content.
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Prévalence et facteurs de risque de stéatose hépatique chez les adultes tunisiens atteints de syndrome d’apnées hypopnées obstructives du sommeil
TL;DR: La steatose hepatique est une comorbidite frequente au cours du SAHOS, d’autant plus qu’ils presentent un âge jeune, une obesite, un IDO eleve et l’elevation des ALAT, est preconisee.
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Relationship of circulating total bilirubin, UDP-glucuronosyltransferases 1A1 and the development of non-alcoholic fatty liver disease: a cross-sectional study
Xuefeng Ma,Xu Zheng,Shousheng Liu,Likun Zhuang,Mengke Wang,Yifen Wang,Yong-Ning Xin,Shi-Ying Xuan +7 more
TL;DR: Wang et al. as discussed by the authors investigated the correlation of circulating total bilirubin (TB) and UGT1A1 with NAFLD in Chinese Han population and found that the circulating TB levels were significantly higher in patients with moderate and severe steatosis.
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Three segments sampling strategy for the assessment of liver steatosis using magnetic resonance imaging proton density fat fraction.
TL;DR: In this paper , the best liver segments representing the whole-liver fat fraction (FF) in magnetic resonance imaging (MRI)-based measurement of the proton density fat fraction was determined.
References
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Design and validation of a histological scoring system for nonalcoholic fatty liver disease
David E. Kleiner,Elizabeth M. Brunt,Mark L. Van Natta,Cynthia Behling,Melissa J. Contos,Oscar W. Cummings,Linda D. Ferrell,Yao Chang Liu,Michael Torbenson,Aynur Unalp-Arida,Matthew M. Yeh,Arthur J. McCullough,Arun J. Sanyal +12 more
TL;DR: A strong scoring system and NAS for NAFLD and NASH with reasonable inter‐rater reproducibility that should be useful for studies of both adults and children with any degree ofNAFLD are presented.
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Prevalence of Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis Among a Largely Middle-Aged Population Utilizing Ultrasound and Liver Biopsy: A Prospective Study
Christopher D. Williams,Joel Z. Stengel,Michael I. Asike,Dawn M. Torres,Janet Shaw,Maricela Contreras,Cristy L. Landt,Stephen A. Harrison +7 more
TL;DR: Prevalence of nonalcoholic fatty liver disease and NASH is higher than estimated previously and Hispanics and patients with diabetes are at greatest risk for both NAFLD and NASh.
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Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
Brent A. Neuschwander-Tetri,Rohit Loomba,Arun J. Sanyal,Joel E. Lavine,Mark L. Van Natta,Manal F. Abdelmalek,Naga Chalasani,Srinivasan Dasarathy,Anna Mae Diehl,Bilal Hameed,Kris V. Kowdley,Arthur J. McCullough,Norah A. Terrault,Jeanne M. Clark,James Tonascia,Elizabeth M. Brunt,David E. Kleiner,Edward Doo +17 more
TL;DR: Obeticholic acid improved the histological features of non-alcoholic steatohepatitis, but its long-term benefits and safety need further clarification.
Journal ArticleDOI
Estimation of Error Rates in Discriminant Analysis
TL;DR: In this article, several methods of estimating error rates in discriminant analysis are evaluated by sampling methods, and two methods in most common use are found to be significantly poorer than some new methods that are proposed.
Journal ArticleDOI
The global NAFLD epidemic
Rohit Loomba,Arun J. Sanyal +1 more
TL;DR: The similarities and differences in the epidemiology of NAFLD in different regions of the world are discussed and the potential role of genetics and insulin resistance in disease progression is also presented.