Journal ArticleDOI
Ambient air pollution: An emerging risk factor for diabetes mellitus
Xiaoquan Rao,Jessica Montresor-Lopez,Robin C. Puett,Sanjay Rajagopalan,Robert D. Brook,Robert D. Brook +5 more
TLDR
This review summarizes recent findings from epidemiologic studies and mechanistic insights that provide links between exposure to air pollution and a heightened risk for diabetes.Abstract:
Growing evidence supports that air pollution has become an important risk factor for developing diabetes mellitus. Understanding the contributing effect of air pollution in population studies, elucidating the potential mechanisms involved, and identifying the most responsible pollutants are all required in order to promulgate successful changes in policy and to help formulate preventive measures in an effort to reduce the risk for diabetes. This review summarizes recent findings from epidemiologic studies and mechanistic insights that provide links between exposure to air pollution and a heightened risk for diabetes.read more
Citations
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Journal ArticleDOI
Global aetiology and epidemiology of type 2 diabetes mellitus and its complications.
TL;DR: An updated view of the global epidemiology of type 2 diabetes mellitus, as well as dietary, lifestyle and other risk factors for T2DM and its complications are provided.
Journal ArticleDOI
Air Pollution and Cardiovascular Disease: JACC State-of-the-Art Review
TL;DR: This review provides an overview of air pollution and health, including assessment of exposure, impact on CV outcomes, mechanistic underpinnings, and impact ofAir pollution reduction strategies to mitigate CV risk, and concludes with future challenges.
Journal ArticleDOI
Environmental determinants of cardiovascular disease: lessons learned from air pollution.
TL;DR: The empirical evidence supporting the effects of air pollution on cardiovascular health is examined, potential mechanisms that lead to increased cardiovascular risk are described, and measures to reduce this risk and identify key gaps in knowledge that could help address the increasing cardiovascular morbidity and mortality associated with air pollution are discussed.
Journal ArticleDOI
Environmental stressors and cardio-metabolic disease: part I-epidemiologic evidence supporting a role for noise and air pollution and effects of mitigation strategies.
Thomas Münzel,Mette Sørensen,Tommaso Gori,Frank P. Schmidt,Xiaoquan Rao,Jeffrey R. Brook,Lung Chi Chen,Robert D. Brook,Sanjay Rajagopalan +8 more
TL;DR: Increased awareness of the societal burden posed by these novel risk factors and acknowledgement in traditional risk factor guidelines may intensify the efforts required for effective legislation to reduce air pollution and noise.
Journal ArticleDOI
Effects of gaseous and solid constituents of air pollution on endothelial function.
Thomas Münzel,Tommaso Gori,Sadeer G. Al-Kindi,John E. Deanfield,Jos Lelieveld,Andreas Daiber,Sanjay Rajagopalan +6 more
TL;DR: An exhortation for formal inclusion of air pollution as a major risk factor in societal guidelines and provision of formal recommendations to prevent adverse cardiovascular effects attributable to air pollution is exhorted.
References
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TL;DR: In this paper, the authors estimated deaths and disability-adjusted life years (DALYs; sum of years lived with disability [YLD] and years of life lost [YLL]) attributable to the independent effects of 67 risk factors and clusters of risk factors for 21 regions in 1990 and 2010.
Journal ArticleDOI
Inflammation and metabolic disorders
TL;DR: Dysfunction of the immune response and metabolic regulation interface can be viewed as a central homeostatic mechanism, dysfunction of which can lead to a cluster of chronic metabolic disorders, particularly obesity, type 2 diabetes and cardiovascular disease.
Journal ArticleDOI
Particulate Matter Air Pollution and Cardiovascular Disease An Update to the Scientific Statement From the American Heart Association
Robert D. Brook,Sanjay Rajagopalan,C. Arden Pope,Jeffrey R. Brook,Aruni Bhatnagar,Ana V. Diez-Roux,Fernando Holguin,Yuling Hong,Russell V. Luepker,Murray A. Mittleman,Annette Peters,David S. Siscovick,Sidney C. Smith,Laurie P. Whitsel,Joel D. Kaufman +14 more
TL;DR: It is the opinion of the writing group that the overall evidence is consistent with a causal relationship between PM2.5 exposure and cardiovascular morbidity and mortality.
Journal ArticleDOI
Abdominal obesity and metabolic syndrome
TL;DR: This work has shown that abdominal obesity — the most prevalent manifestation of metabolic syndrome — is a marker of 'dysfunctional adipose tissue', and is of central importance in clinical diagnosis.
Journal ArticleDOI
Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica.
Catherine Dostert,Virginie Pétrilli,Robin van Bruggen,Chad Steele,Brooke T. Mossman,Jürg Tschopp +5 more
TL;DR: It is shown that asbestos and silica are sensed by the Nalp3 inflammasome, whose subsequent activation leads to interleukin-1β secretion, and support its role as a major proinflammatory “danger” receptor in particulate matter–related pulmonary diseases.