An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-Based Guidelines for Diagnosis and Management
Ganesh Raghu,Harold R. Collard,Jim J. Egan,Fernando J. Martinez,Juergen Behr,Kevin K. Brown,Thomas V. Colby,Jean-François Cordier,Kevin R. Flaherty,Joseph A. Lasky,David A. Lynch,Jay H. Ryu,Jeffrey J. Swigris,Athol U. Wells,Julio Ancochea,Demosthenes Bouros,Carlos Roberto Ribeiro de Carvalho,Ulrich Costabel,Masahito Ebina,David M. Hansell,Takeshi Johkoh,Dong Soon Kim,Talmadge E. King,Yasuhiro Kondoh,Jeffrey L. Myers,Nestor L. Müller,Andrew G. Nicholson,Luca Richeldi,Moisés Selman,Rosalind F. Dudden,Barbara S. Griss,Shandra Protzko,Holger J. Schünemann +32 more
TLDR
This document represents the current state of knowledge regarding idiopathic pulmonary fibrosis, and contains sections on definition and epidemiology, risk factors, diagnosis, natural history, staging and prognosis, treatment, and monitoring disease course.Abstract:
This document is an international evidence-based guideline on the diagnosis and management of idiopathic pulmonary fibrosis, and is a collaborative effort of the American Thoracic Society, the European Respiratory Society, the Japanese Respiratory Society, and the Latin American Thoracic Association. It represents the current state of knowledge regarding idiopathic pulmonary fibrosis (IPF), and contains sections on definition and epidemiology, risk factors, diagnosis, natural history, staging and prognosis, treatment, and monitoring disease course. For the diagnosis and treatment sections, pragmatic GRADE evidence-based methodology was applied in a question-based format. For each diagnosis and treatment question, the committee graded the quality of the evidence available (high, moderate, low, or very low), and made a recommendation (yes or no, strong or weak). Recommendations were based on majority vote. It is emphasized that clinicians must spend adequate time with patients to discuss patients' values and preferences and decide on the appropriate course of action.read more
Citations
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Endurance Time Is the Most Responsive Exercise Measurement in Idiopathic Pulmonary Fibrosis
Shinichi Arizono,Hiroyuki Taniguchi,Koji Sakamoto,Yasuhiro Kondoh,Tomoki Kimura,Kensuke Kataoka,Tomoya Ogawa,Fumiko Watanabe,Osamu Nishiyama,Koichi Nishimura,Ryo Kozu,Kazuyuki Tabira +11 more
TL;DR: ET is the most responsive exercise measurement for evaluating PR efficacy in patients with idiopathic pulmonary fibrosis, and its effect size was as large as 2.96, whereas those of the others were all < 0.5.
Journal ArticleDOI
Galectin-3 Is Associated with Restrictive Lung Disease and Interstitial Lung Abnormalities.
Jennifer E. Ho,Wei Gao,Daniel Levy,Rajalakshmi Santhanakrishnan,Tetsuro Araki,Ivan O. Rosas,Hiroto Hatabu,Jeanne C. Latourelle,Mizuki Nishino,Josée Dupuis,Josée Dupuis,George R. Washko,George T. O'Connor,Gary M. Hunninghake +13 more
TL;DR: Elevated Gal-3 concentrations are associated with interstitial lung abnormalities coupled with a restrictive pattern, including decreased lung volumes and altered gas exchange, which suggest a potential role for Gal- 3 in early stages of pulmonary fibrosis.
Journal ArticleDOI
Efficacy of chemotherapy for advanced non-small cell lung cancer with idiopathic pulmonary fibrosis.
Naohiro Watanabe,Hiroyuki Taniguchi,Yasuhiro Kondoh,Tomoki Kimura,Kensuke Kataoka,Osamu Nishiyama,Masashi Kondo,Yoshinori Hasegawa +7 more
TL;DR: This study showed that advanced NSCLC patients with IPF may benefit from chemotherapy; well-controlled studies are still needed to clarify the efficacy.
Journal ArticleDOI
Postoperative pulmonary complications after surgery in patients with interstitial lung disease.
Sun Mi Choi,Jinwoo Lee,Young Sik Park,Young Jae Cho,Changhoon Lee,Sangmin Lee,Ho Il Yoon,Jae-Joon Yim,Jae-Ho Lee,Chul Gyu Yoo,Choon Taek Lee,Young Whan Kim,Jongsun Park +12 more
TL;DR: The incidence of PPCs detected over all surgeries was not as high as that reported for lung surgery alone in ILD patients, and lower BMI, emergency surgery, lung surgery, and longer anesthesia time were risk factors.
Journal ArticleDOI
Syndecan-2 Exerts Antifibrotic Effects by Promoting Caveolin-1–mediated Transforming Growth Factor-β Receptor I Internalization and Inhibiting Transforming Growth Factor-β1 Signaling
Yuanyuan Shi,Bernadette R. Gochuico,Guoying Yu,Xiaomeng Tang,Juan C. Osorio,Isis E. Fernandez,Cristobal Risquez,Avignat Patel,Ying Shi,Marc G. Wathelet,Andrew J. Goodwin,Jeffrey A. Haspel,Stefan W. Ryter,Eric M. Billings,Naftali Kaminski,Danielle Morse,Ivan O. Rosas +16 more
TL;DR: Alveolar macrophage syndecan-2 exerts antifibrotic effects by promoting caveolin-1-dependent TGF-β1 and TβRI internalization and inhibiting TGF -β1 signaling in alveolar epithelial cells, and molecules that facilitate T βRI degradation via endocytosis represent potential therapies for pulmonary fibrosis.
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