An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-Based Guidelines for Diagnosis and Management
Ganesh Raghu,Harold R. Collard,Jim J. Egan,Fernando J. Martinez,Juergen Behr,Kevin K. Brown,Thomas V. Colby,Jean-François Cordier,Kevin R. Flaherty,Joseph A. Lasky,David A. Lynch,Jay H. Ryu,Jeffrey J. Swigris,Athol U. Wells,Julio Ancochea,Demosthenes Bouros,Carlos Roberto Ribeiro de Carvalho,Ulrich Costabel,Masahito Ebina,David M. Hansell,Takeshi Johkoh,Dong Soon Kim,Talmadge E. King,Yasuhiro Kondoh,Jeffrey L. Myers,Nestor L. Müller,Andrew G. Nicholson,Luca Richeldi,Moisés Selman,Rosalind F. Dudden,Barbara S. Griss,Shandra Protzko,Holger J. Schünemann +32 more
TLDR
This document represents the current state of knowledge regarding idiopathic pulmonary fibrosis, and contains sections on definition and epidemiology, risk factors, diagnosis, natural history, staging and prognosis, treatment, and monitoring disease course.Abstract:
This document is an international evidence-based guideline on the diagnosis and management of idiopathic pulmonary fibrosis, and is a collaborative effort of the American Thoracic Society, the European Respiratory Society, the Japanese Respiratory Society, and the Latin American Thoracic Association. It represents the current state of knowledge regarding idiopathic pulmonary fibrosis (IPF), and contains sections on definition and epidemiology, risk factors, diagnosis, natural history, staging and prognosis, treatment, and monitoring disease course. For the diagnosis and treatment sections, pragmatic GRADE evidence-based methodology was applied in a question-based format. For each diagnosis and treatment question, the committee graded the quality of the evidence available (high, moderate, low, or very low), and made a recommendation (yes or no, strong or weak). Recommendations were based on majority vote. It is emphasized that clinicians must spend adequate time with patients to discuss patients' values and preferences and decide on the appropriate course of action.read more
Citations
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Journal ArticleDOI
The Role of TGF-β Signaling in Lung Cancer Associated with Idiopathic Pulmonary Fibrosis
TL;DR: The molecular mechanisms that underlie the occurrence of lung cancer in the background of IPF are explored, with an emphasis on the multifaceted effects of TGF-β signaling.
Journal ArticleDOI
Surgical Lung Biopsy for Interstitial Lung Diseases.
TL;DR: When a SLB can be diagnostic as well as when it may be avoided; for example, when the combination of the clinical context and the imaging pattern seen on high‐resolution CT chest scans can provide a confident diagnosis.
Journal ArticleDOI
Distinct profile and prognostic impact of body composition changes in idiopathic pulmonary fibrosis and idiopathic pleuroparenchymal fibroelastosis.
Yuzo Suzuki,Katsuhiro Yoshimura,Yasunori Enomoto,Hideki Yasui,Hironao Hozumi,Masato Karayama,Kazuki Furuhashi,Noriyuki Enomoto,Tomoyuki Fujisawa,Yutaro Nakamura,Naoki Inui,Takafumi Suda +11 more
TL;DR: Values to measure body composition changes in managing patients with IPF and iPPFE are suggested, as distinct changes in body composition had prognostic significance among patients withIPF and iPPFE.
Journal ArticleDOI
[ 18 F]FDG PET/CT predicts progression-free survival in patients with idiopathic pulmonary fibrosis
Aurélien Justet,Astrid Laurent-Bellue,Gabriel Thabut,Arnaud Dieudonné,Marie-Pierre Debray,Raphael Borie,Michel Aubier,Rachida Lebtahi,Bruno Crestani +8 more
TL;DR: FDG lung uptake may be a marker of IPF severity and predict progression-free survival for patients with IPF.
Journal ArticleDOI
Danger-Associated Molecular Patterns and Danger Signals in Idiopathic Pulmonary Fibrosis
TL;DR: The impact of MPs resulting from infection-driven apoptosis and necrosis during chronic fibrotic lung disease is focused on.
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TL;DR: The Diagnostic Process Is Dynamic Clinical Evaluation Radiological Evaluation Role of Surgical Lung Biopsy Unclassifiable Interstitial Pneumonia Bronchoalveolar Lavage Fluid Evaluation Idiopathic Pulmonary Fibrosis.
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