An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-Based Guidelines for Diagnosis and Management
Ganesh Raghu,Harold R. Collard,Jim J. Egan,Fernando J. Martinez,Juergen Behr,Kevin K. Brown,Thomas V. Colby,Jean-François Cordier,Kevin R. Flaherty,Joseph A. Lasky,David A. Lynch,Jay H. Ryu,Jeffrey J. Swigris,Athol U. Wells,Julio Ancochea,Demosthenes Bouros,Carlos Roberto Ribeiro de Carvalho,Ulrich Costabel,Masahito Ebina,David M. Hansell,Takeshi Johkoh,Dong Soon Kim,Talmadge E. King,Yasuhiro Kondoh,Jeffrey L. Myers,Nestor L. Müller,Andrew G. Nicholson,Luca Richeldi,Moisés Selman,Rosalind F. Dudden,Barbara S. Griss,Shandra Protzko,Holger J. Schünemann +32 more
TLDR
This document represents the current state of knowledge regarding idiopathic pulmonary fibrosis, and contains sections on definition and epidemiology, risk factors, diagnosis, natural history, staging and prognosis, treatment, and monitoring disease course.Abstract:
This document is an international evidence-based guideline on the diagnosis and management of idiopathic pulmonary fibrosis, and is a collaborative effort of the American Thoracic Society, the European Respiratory Society, the Japanese Respiratory Society, and the Latin American Thoracic Association. It represents the current state of knowledge regarding idiopathic pulmonary fibrosis (IPF), and contains sections on definition and epidemiology, risk factors, diagnosis, natural history, staging and prognosis, treatment, and monitoring disease course. For the diagnosis and treatment sections, pragmatic GRADE evidence-based methodology was applied in a question-based format. For each diagnosis and treatment question, the committee graded the quality of the evidence available (high, moderate, low, or very low), and made a recommendation (yes or no, strong or weak). Recommendations were based on majority vote. It is emphasized that clinicians must spend adequate time with patients to discuss patients' values and preferences and decide on the appropriate course of action.read more
Citations
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Journal ArticleDOI
Comprehensive care of the patient with idiopathic pulmonary fibrosis
TL;DR: The comprehensive care of the patient with IPF involves balancing the three pillars of disease- centered management, symptom-centered management, and patient education and self-management upon a solid foundation of provider–patient partnership.
Journal ArticleDOI
Stem cell therapy for idiopathic pulmonary fibrosis: a protocol proposal
Argyris Tzouvelekis,George Koliakos,Paschalis Ntolios,Irene Baira,Evangelos Bouros,Anastasia Oikonomou,Athanassios Zissimopoulos,George Kolios,Despoina Kakagia,Vassilis Paspaliaris,Ioannis Kotsianidis,Marios Froudarakis,Demosthenes Bouros +12 more
TL;DR: Adipose tissue represents an abundant, safe, ethically uncontested and potentially beneficial source of stem cells for patients with IPF, and pilot safety studies are of major importance and represent the first hamper that should be overcome to establish a rigid basis for larger clinical trials.
Journal ArticleDOI
Histopathology of Interstitial Lung Abnormalities in the Context of Lung Nodule Resections
Ezra R. Miller,Rachel K. Putman,Marina Vivero,Yin Hung,Tetsuro Araki,Mizuki Nishino,George R. Washko,Ivan O. Rosas,Hiroto Hatabu,Lynette M. Sholl,Gary M. Hunninghake +10 more
TL;DR: A primer on the use of mouse models for identifying direct sex chromosome effects that cause sex differences in non-gonadal tissues and the importance of having two X chromosomes is provided.
Journal ArticleDOI
Idiopathic non-specific interstitial pneumonia.
TL;DR: Patients typically present in mid‐adulthood with dyspnoea, cough and often constitutional symptoms including fever and fatigue, and treatment of idiopathic NSIP is generally instituted in the form of immunosuppression.
Journal ArticleDOI
Phase 2 clinical trial of PBI-4050 in patients with idiopathic pulmonary fibrosis
Nasreen Khalil,Hélène Manganas,Christopher J. Ryerson,Shane Shapera,André M. Cantin,Paul Hernandez,Eric Turcotte,Joseph M. Parker,John E. Moran,Gary R. Albert,Renata Sawtell,Aline Hagerimana,Pierre Laurin,Lyne Gagnon,Frank Cesari,Martin Kolb +15 more
TL;DR: PBI-4050 alone and in combination with nintedanib demonstrated no safety concerns and showed encouraging results for lung function in IPF patients, suggesting a drug–drug interaction.
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American thoracic society/European respiratory society international multidisciplinary consensus classification of the idiopathic interstitial pneumonias
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TL;DR: The Diagnostic Process Is Dynamic Clinical Evaluation Radiological Evaluation Role of Surgical Lung Biopsy Unclassifiable Interstitial Pneumonia Bronchoalveolar Lavage Fluid Evaluation Idiopathic Pulmonary Fibrosis.
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David M. Hansell,Alexander A. Bankier,Heber MacMahon,Theresa C. McLoud,Nestor L. Müller,J Remy +5 more
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