An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-Based Guidelines for Diagnosis and Management
Ganesh Raghu,Harold R. Collard,Jim J. Egan,Fernando J. Martinez,Juergen Behr,Kevin K. Brown,Thomas V. Colby,Jean-François Cordier,Kevin R. Flaherty,Joseph A. Lasky,David A. Lynch,Jay H. Ryu,Jeffrey J. Swigris,Athol U. Wells,Julio Ancochea,Demosthenes Bouros,Carlos Roberto Ribeiro de Carvalho,Ulrich Costabel,Masahito Ebina,David M. Hansell,Takeshi Johkoh,Dong Soon Kim,Talmadge E. King,Yasuhiro Kondoh,Jeffrey L. Myers,Nestor L. Müller,Andrew G. Nicholson,Luca Richeldi,Moisés Selman,Rosalind F. Dudden,Barbara S. Griss,Shandra Protzko,Holger J. Schünemann +32 more
TLDR
This document represents the current state of knowledge regarding idiopathic pulmonary fibrosis, and contains sections on definition and epidemiology, risk factors, diagnosis, natural history, staging and prognosis, treatment, and monitoring disease course.Abstract:
This document is an international evidence-based guideline on the diagnosis and management of idiopathic pulmonary fibrosis, and is a collaborative effort of the American Thoracic Society, the European Respiratory Society, the Japanese Respiratory Society, and the Latin American Thoracic Association. It represents the current state of knowledge regarding idiopathic pulmonary fibrosis (IPF), and contains sections on definition and epidemiology, risk factors, diagnosis, natural history, staging and prognosis, treatment, and monitoring disease course. For the diagnosis and treatment sections, pragmatic GRADE evidence-based methodology was applied in a question-based format. For each diagnosis and treatment question, the committee graded the quality of the evidence available (high, moderate, low, or very low), and made a recommendation (yes or no, strong or weak). Recommendations were based on majority vote. It is emphasized that clinicians must spend adequate time with patients to discuss patients' values and preferences and decide on the appropriate course of action.read more
Citations
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Methotrexate and rheumatoid arthritis associated interstitial lung disease.
Pierre-Antoine Juge,Joyce S. Lee,Jessica Lau,Leticia Kawano-Dourado,Jorge Rojas Serrano,Marco Sebastiani,Gouri Koduri,Eric L. Matteson,Karina Bonfiglioli,Marcio Valente Yamada Sawamura,Ronaldo Adib Kairalla,Lorenzo Cavagna,Emanuele Bozzalla Cassione,Andreina Teresa Manfredi,Mayra Mejía,Pedro Rodríguez-Henriquez,Montserrat I González-Pérez,Ramcés Falfán-Valencia,Ivette Buendía-Roldán,Gloria Pérez-Rubio,Esther Ebstein,Steven Gazal,Steven Gazal,Raphael Borie,Sébastien Ottaviani,Caroline Kannengiesser,Benoit Wallaert,Yurdagul Uzunhan,Hilario Nunes,Dominique Valeyre,Nathalie Saidenberg-Kermanac’h,Marie-Christophe Boissier,Lidwine Wemeau-Stervinou,René-Marc Flipo,Sylvain Marchand-Adam,Pascal Richette,Pascal Richette,Yannick Allanore,Yannick Allanore,Claire Dromer,Marie-Elise Truchetet,Christophe Richez,Thierry Schaeverbeke,Huguette Lioté,Gabriel Thabut,Kevin D. Deane,Joshua J. Solomon,Tracy J. Doyle,Jay H. Ryu,Ivan O. Rosas,V. Michael Holers,Catherine Boileau,Marie-Pierre Debray,Raphaël Porcher,David A. Schwartz,Robert Vassallo,Bruno Crestani,Philippe Dieudé +57 more
TL;DR: The results suggest that MTX use is not associated with an increased risk of RA-ILD in patients with RA, and that ILD was detected later in MTX-treated patients.
Journal ArticleDOI
Pre-existing pulmonary fibrosis is a risk factor for anti-PD-1-related pneumonitis in patients with non-small cell lung cancer: A retrospective analysis.
Teppei Yamaguchi,Junichi Shimizu,Takaaki Hasegawa,Yoshitsugu Horio,Yoshitaka Inaba,Yasushi Yatabe,Toyoaki Hida +6 more
TL;DR: It is indicated that pre-existing pulmonary fibrosis significantly increases the risk of anti-PD-1-related pneumonitis in patients with fibrotic changes on CT findings.
Journal ArticleDOI
Predicting Pulmonary Fibrosis Disease Course From Past Trends in Pulmonary Function
Shelley L. Schmidt,Nabihah Tayob,MeiLan K. Han,Christopher Zappala,Dolly Kervitsky,Susan Murray,Athol U. Wells,Kevin K. Brown,Fernando J. Martinez,Kevin R. Flaherty +9 more
TL;DR: PFT decline predicts early mortality, but not future declines in physiology, regardless of time since diagnosis, according to prior trends in pulmonary function tests.
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Idiopathic pulmonary fibrosis: immunohistochemical analysis provides fresh insights into lung tissue remodelling with implications for novel prognostic markers
TL;DR: The pathogenesis of IPF is complex and involves multiple factors, possibly including EMT, and marker expression (N-cadherin and Ki-67) correlation with histological disease activity (as reflected by fibroblastic foci extent) may emerge as future prognostic indicators for IPF.
Journal ArticleDOI
Genetics in Idiopathic Pulmonary Fibrosis Pathogenesis, Prognosis, and Treatment
TL;DR: Better understanding of how genetic variation plays a role in disease risk and phenotype could identify potential therapeutic targets and inform clinical decision-making and allow the development of personalized approaches to the IPF management.
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TL;DR: The Diagnostic Process Is Dynamic Clinical Evaluation Radiological Evaluation Role of Surgical Lung Biopsy Unclassifiable Interstitial Pneumonia Bronchoalveolar Lavage Fluid Evaluation Idiopathic Pulmonary Fibrosis.
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