Journal ArticleDOI
Antimicrobial activity of metals: mechanisms, molecular targets and applications
Reads0
Chats0
TLDR
The chemical and toxicological principles that underlie the antimicrobial activity of metals are described and the preferences of metal atoms for specific microbial targets are discussed.Abstract:
Metals have been used as antimicrobial agents since antiquity, but throughout most of history their modes of action have remained unclear. Recent studies indicate that different metals cause discrete and distinct types of injuries to microbial cells as a result of oxidative stress, protein dysfunction or membrane damage. Here, we describe the chemical and toxicological principles that underlie the antimicrobial activity of metals and discuss the preferences of metal atoms for specific microbial targets. Interdisciplinary research is advancing not only our understanding of metal toxicity but also the design of metal-based compounds for use as antimicrobial agents and alternatives to antibiotics.read more
Citations
More filters
Journal ArticleDOI
Roles of bacterial cell and extracellular polymeric substance on adsorption of Cu(II) in activated sludges: A comparative study
TL;DR: In this article, the role of bacterial cell and extracellular polymeric substance (EPS) on adsorption of heavy metal remains elusive, and the authors found that the EPS content highly positively correlated with the Cu(II) content adsorbed by EPS.
Journal ArticleDOI
Accelerated spread of antibiotic resistance genes (ARGs) induced by non-antibiotic conditions: Roles and mechanisms.
TL;DR: In this paper , a review assessed the evolution of ARGs, especially its function alteration, summarized the non-antibiotic chemicals promoting the spread of ARG and analyzed the molecular mechanisms.
Journal ArticleDOI
Irradiation with visible light enhances the antibacterial toxicity of silver nanoparticles produced by laser ablation
Matthew Ratti,J. J. Naddeo,Yuying Tan,Julianne C. Griepenburg,John A. Tomko,Cory Trout,S. M. O’Malley,D. M. Bubb,Eric A. Klein +8 more
TL;DR: It is demonstrated that the antibacterial efficacy of silver nanoparticles (AgNPs) is enhanced with exposure to light from the visible spectrum and this findings provide a novel paradigm for using light to regulate the toxicity of AgNPs which may have a significant impact in the development of new antimicrobial therapeutics.
Book ChapterDOI
Healthy components of coffee processing by-products
TL;DR: In this paper, the authors explored the antioxidant components of coffee and coffee by-products, gave some background on antioxidants (what they are and how to study them) and how these relate to health.
Journal ArticleDOI
Microwave Intensified Synthesis: Batch and Flow Chemistry.
TL;DR: The experimental design strategies and fundamentals of the microwave interaction with chemicals are presented, and the recent procedure of using fluidic reactors on preparing both metals and metal oxides nanoparticles is highlighted.
References
More filters
Journal ArticleDOI
Hard and soft acids and bases
TL;DR: In this paper, the rate data for the generalized nucleophilic displacement reaction were reviewed, and the authors presented a method to estimate the rate of the generalized displacement reaction in terms of the number of nucleophiles.
Journal ArticleDOI
Absolute hardness: companion parameter to absolute electronegativity
Robert G. Parr,Ralph G. Pearson +1 more
TL;DR: In this paper, a property called absolute hardness eta is defined for neutral and charged species, atomic and molecular, for both hard and soft acids and bases, by making use of the hypothesis that extra stability attends bonding of A to B when the ionization potentials of A and B in the molecule are the same.
Journal ArticleDOI
Shape-Controlled Synthesis of Gold and Silver Nanoparticles
Yugang Sun,Younan Xia +1 more
TL;DR: Monodisperse samples of silver nanocubes were synthesized in large quantities by reducing silver nitrate with ethylene glycol in the presence of poly(vinyl pyrrolidone) (PVP), characterized by a slightly truncated shape bounded by {100, {110}, and {111} facets.
Journal ArticleDOI
Free radicals, metals and antioxidants in oxidative stress-induced cancer
TL;DR: This review examines the evidence for involvement of the oxidative stress in the carcinogenesis process and the role of enzymatic and non-enzymatic antioxidants in the process of carcinogenesis as well as the antioxidant interactions with various regulatory factors.
Journal ArticleDOI
The bactericidal effect of silver nanoparticles
Jose Ruben Morones,Jose Luis Elechiguerra,A. Camacho,Katherine B. Holt,Juan B. Kouri,Jose Tapia Ramirez,Miguel Jose Yacaman +6 more
TL;DR: The results indicate that the bactericidal properties of the nanoparticles are size dependent, since the only nanoparticles that present a direct interaction with the bacteria preferentially have a diameter of approximately 1-10 nm.